The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo
Abstract
Neuronal death is a prominent, but poorly understood, pathological hallmark of prion disease. Notably, in the absence of the cellular prion protein (PrP C ), the disease-associated isoform, PrP Sc , appears not to be intrinsically neurotoxic, suggesting that PrP C itself may participate directly in the prion neurodegenerative cascade. Here, cross-linking PrP C in vivo with specific monoclonal antibodies was found to trigger rapid and extensive apoptosis in hippocampal and cerebellar neurons. These findings suggest that PrP C functions in the control of neuronal survival and provides a model to explore whether cross-linking of PrP C by oligomeric PrP Sc can promote neuronal loss during prion infection.
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Cites
Prion Diseases of Humans and Animals: Their Causes and Molecular Basis
Collinge, J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.519 · Cited by 1,344
Normal host prion protein necessary for scrapie-induced neurotoxicity
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Signal Transduction Through Prion Protein
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Depleting Neuronal PrP in Prion Infection Prevents Disease and Reverses Spongiosis
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Antibodies inhibit prion propagation and clear cell cultures of prion infectivity
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Monoclonal antibodies inhibit prion replication and delay the development of prion disease
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Prevention of Scrapie Pathogenesis by Transgenic Expression of Anti-Prion Protein Antibodies
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Cited by
Physiology of the prion protein
Linden, R., Martins, V. R., Prado, M. A. M., Cammarota, M., Izquierdo, I., & Brentani, R. R. (2008) · Physiological Reviews · doi:10.1152/physrev.00007.2007 · Cited by 617
Santuccione, A., Sytnyk, V., Leshchyns'ka, I., & Schachner, M. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200409127 · Cited by 419
The two faces of protein misfolding: gain‐ and loss‐of‐function in neurodegenerative diseases
Winklhofer, K. F., Tatzelt, J., & Haass, C. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601930 · Cited by 401
Molecular Mechanisms of Prion Pathogenesis
Aguzzi, A., Sigurdson, C., & Heikenwaelder, M. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.154326 · Cited by 351
Insights into prion strains and neurotoxicity
Aguzzi, A., Heikenwalder, M., & Polymenidou, M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2204 · Cited by 329
Metadata
- Authors
- Solforosi, L., Criado, J. R., McGavern, D. B., Wirz, S., Sánchez-Alavez, M., Sugama, S., DeGiorgio, L. A., Volpe, B. T., Wiseman, E., Abalos, G., Masliah, E., Gilden, D., Oldstone, M. B., Conti, B., & Williamson, R. A.
- Venue
- Science
- Published
- 2004-03-05
- Volume
- 303
- Issue
- 5663
- Pages
- 1514-1516
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2117064662
- Cited by
- 366
- References
- 13
- FWCI
- 13.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Solforosi, L., Criado, J. R., McGavern, D. B., Wirz, S., Sánchez-Alavez, M., Sugama, S., DeGiorgio, L. A., Volpe, B. T., Wiseman, E., Abalos, G., Masliah, E., Gilden, D., Oldstone, M. B., Conti, B., & Williamson, R. A. (2004). Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo. Science. https://doi.org/10.1126/science.1094273
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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