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Coupling of the TCR to Integrin Activation by SLAP-130/Fyb
Abstract
SLAP-130/Fyb (SLP-76–associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and modulates function of SH2-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76). T cells from mice lacking SLAP-130/Fyb show markedly impaired proliferation following CD3 engagement. In addition, the T cell receptor (TCR) in SLAP-130/Fyb mutant cells fails to enhance integrin-dependent adhesion. Although TCR-induced actin polymerization is normal, TCR-stimulated clustering of the integrin LFA-1 is defective in SLAP-130/Fyb–deficient cells. These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals.
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Citations
Cited by
Smith-Garvin, J. E., Koretzky, G. A., & Jordan, M. S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132706 · Cited by 2,144
Self-citationThe ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
Neel, B. G., Gu, H., & Pao, L. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00091-4 · Cited by 1,249
Dustin, M. L. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0161 · Cited by 502
Intracellular signalling controlling integrin activation in lymphocytes
Kinashi, T. (2005) · Nature Reviews Immunology · doi:10.1038/nri1646 · Cited by 477
Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation
Parravicini, V., Gadina, M., Kovarova, M., Odom, S., Gonzalez-Espinosa, C., Furumoto, Y., Saitoh, S., Samelson, L. E., O'Shea, J. J., & Rivera, J. (2002) · Nature Immunology · doi:10.1038/ni817 · Cited by 448
Metadata
- Authors
- Peterson, E. J., Woods, M. L., Dmowski, S. A., Derimanov, G., Jordan, M. S., Wu, J. N., Myung, P. S., Liu, Q.-H., Pribila, J. T., Freedman, B. D., Shimizu, Y., & Koretzky, G. A.
- Venue
- Science
- Published
- 2001-09-21
- Volume
- 293
- Issue
- 5538
- Pages
- 2263-2265
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2098409714
- Cited by
- 318
- References
- 0
- FWCI
- 14.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Peterson, E. J., Woods, M. L., Dmowski, S. A., Derimanov, G., Jordan, M. S., Wu, J. N., Myung, P. S., Liu, Q.-H., Pribila, J. T., Freedman, B. D., Shimizu, Y., & Koretzky, G. A. (2001). Coupling of the TCR to Integrin Activation by SLAP-130/Fyb. Science. https://doi.org/10.1126/science.1063486
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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