The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β
Abstract
Blood vessels express estrogen receptors, but their role in cardiovascular physiology is not well understood. We show that vascular smooth muscle cells and blood vessels from estrogen receptor β (ERβ)–deficient mice exhibit multiple functional abnormalities. In wild-type mouse blood vessels, estrogen attenuates vasoconstriction by an ERβ-mediated increase in inducible nitric oxide synthase expression. In contrast, estrogen augments vasoconstriction in blood vessels from ERβ-deficient mice. Vascular smooth muscle cells isolated from ERβ-deficient mice show multiple abnormalities of ion channel function. Furthermore, ERβ-deficient mice develop sustained systolic and diastolic hypertension as they age. These data support an essential role for ERβ in the regulation of vascular function and blood pressure.
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Cites
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Cited by
Pickering, T. G., Hall, J. E., Appel, L. J., Falkner, B. E., Graves, J., Hill, M. N., Jones, D. W., Kurtz, T., Sheps, S. G., & Roccella, E. J. (2005) · Circulation · doi:10.1161/01.cir.0000154900.76284.f6 · Cited by 3,985
Pickering, T. G., Hall, J. E., Appel, L. J., Falkner, B. E., Graves, J., Hill, M. N., Jones, D. W., Kurtz, T., Sheps, S. G., & Roccella, E. J. (2005) · Hypertension · doi:10.1161/01.hyp.0000150859.47929.8e · Cited by 2,051
Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential
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Gender, sex hormones, and vascular tone
Orshal, J. M., & Khalil, R. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00338.2003 · Cited by 650
International Union of Pharmacology. LXIV. Estrogen Receptors
Dahlman-Wright, K., Cavailles, V., Fuqua, S. A., Jordan, V. C., Katzenellenbogen, J. A., Korach, K. S., Maggi, A., Muramatsu, M., Parker, M. G., & Gustafsson, J.-Å. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.8 · Cited by 583
Self-citation
Metadata
- Authors
- Zhu, Y., Bian, Z., Lu, P., Karas, R. H., Bao, L., Cox, D., Hodgin, J., Shaul, P. W., Thorén, P., Smithies, O., Gustafsson, J.-Å., & Mendelsohn, M. E.
- Venue
- Science
- Published
- 2002-01-18
- Volume
- 295
- Issue
- 5554
- Pages
- 505-508
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2147315723
- Cited by
- 482
- References
- 25
- FWCI
- 21.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhu, Y., Bian, Z., Lu, P., Karas, R. H., Bao, L., Cox, D., Hodgin, J., Shaul, P. W., Thorén, P., Smithies, O., Gustafsson, J.-Å., & Mendelsohn, M. E. (2002). Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β. Science. https://doi.org/10.1126/science.1065250
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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