The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
A Prokaryotic Voltage-Gated Sodium Channel
Abstract
The pore-forming subunits of canonical voltage-gated sodium and calcium channels are encoded by four repeated domains of six-transmembrane (6TM) segments. We expressed and characterized a bacterial ion channel (NaChBac) from Bacillus halodurans that is encoded by one 6TM segment. The sequence, especially in the pore region, is similar to that of voltage-gated calcium channels. The expressed channel was activated by voltage and was blocked by calcium channel blockers. However, the channel was selective for sodium. The identification of NaChBac as a functionally expressed bacterial voltage-sensitive ion-selective channel provides insight into both voltage-dependent activation and divalent cation selectivity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity
Doyle, D. A., Cabral, J. M., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., Chait, B. T., & MacKinnon, R. (1998) · Science · doi:10.1126/science.280.5360.69 · Cited by 6,807
From Ionic Currents to Molecular Mechanisms
Catterall, W. A. (2000) · Neuron · doi:10.1016/s0896-6273(00)81133-2 · Cited by 2,118
Structural parts involved in activation and inactivation of the sodium channel
Stühmer, W., Conti, F., Suzuki, H., Wang, X., Noda, M., Yahagi, N., Kubo, H., & Numa, S. (1989) · Nature · doi:10.1038/339597a0 · Cited by 1,215
Clapham, D. E., Runnels, L. W., & Strübing, C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35077544 · Cited by 1,153
Self-citationA sperm ion channel required for sperm motility and male fertility
Ren, D., Navarro, B., Perez, G., Jackson, A. C., Hsu, S., Shi, Q., Tilly, J. L., & Clapham, D. E. (2001) · Nature · doi:10.1038/35098027 · Cited by 957
Self-citationCalcium channel characteristics conferred on the sodium channel by single mutations
Heinemann, S. H., Terlau, H., Stühmer, W., Imoto, K., & Numa, S. (1992) · Nature · doi:10.1038/356441a0 · Cited by 784
Persistent Sodium Current in Mammalian Central Neurons
Crill, W. E. (1996) · Annual Review of Physiology · doi:10.1146/annurev.ph.58.030196.002025 · Cited by 632
Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels
Yang, J., Elllnor, P. T., Sather, W. A., Zhang, J.-F., & Tsien, R. W. (1993) · Nature · doi:10.1038/366158a0 · Cited by 617
Takami, H. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.21.4317 · Cited by 533
Cummins, T. R., Dib-Hajj, S. D., Black, J. A., Akopian, A. N., Wood, J. N., & Waxman, S. G. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-24-j0001.1999 · Cited by 476
Cited by
The crystal structure of a voltage-gated sodium channel
Payandeh, J., Scheuer, T., Zheng, N., & Catterall, W. A. (2011) · Nature · doi:10.1038/nature10238 · Cited by 1,429
Equalizing excitation-inhibition ratios across visual cortical neurons
Xue, M., Atallah, B. V., & Scanziani, M. (2014) · Nature · doi:10.1038/nature13321 · Cited by 722
Voltage‐gated sodium channels at 60: structure, function and pathophysiology
Catterall, W. A. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.224204 · Cited by 719
The voltage-gated potassium channels and their relatives
Yellen, G. (2002) · Nature · doi:10.1038/nature00978 · Cited by 706
Overview of the voltage-gated sodium channel family
Yu (2003) · Genome biology · doi:10.1186/gb-2003-4-3-207 · Cited by 694
Metadata
- Authors
- Ren, D., Navarro, B., Xu, H., Yue, L., Shi, Q., & Clapham, D. E.
- Venue
- Science
- Published
- 2001-12-14
- Volume
- 294
- Issue
- 5550
- Pages
- 2372-2375
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969577194
- Cited by
- 506
- References
- 28
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Prokaryotic Voltage-Gated Sodium Channel. https://app.cochat.ai/papers/10.1126/science.1065635
- The paper
- Ren, D., Navarro, B., Xu, H., Yue, L., Shi, Q., & Clapham, D. E. (2001). A Prokaryotic Voltage-Gated Sodium Channel. Science. https://doi.org/10.1126/science.1065635
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
