The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Helicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation
Open accessAbstract
Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H . pylori and show that H . pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid–binding adhesin (SabA) was isolated with the “retagging” method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H . pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H . pylori infection.
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The complete genome sequence of the gastric pathogen Helicobacter pylori
Tomb, J.-F., White, O., Kerlavage, A. R., Clayton, R. A., Sutton, G. G., Fleischmann, R. D., Ketchum, K. A., Klenk, H. P., Gill, S., Dougherty, B. A., et al. (1997) · Nature · doi:10.1038/41483 · Cited by 3,529
Self-citationAlm, R. A., Ling, L.-S. L., Moir, D. T., King, B. L., Brown, E. D., Doig, P. C., Smith, D. R., Noonan, B., Guild, B. C., deJonge, B. L., et al. (1999) · Nature · doi:10.1038/16495 · Cited by 1,893
Cited by
Gut biogeography of the bacterial microbiota
Donaldson, G. P., Lee, S. M., & Mazmanian, S. K. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro3552 · Cited by 2,535
Pathogenesis of Helicobacter pylori Infection
Kusters, J. G., van Vliet, A. H. M., & Kuipers, E. J. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00054-05 · Cited by 2,526
Mucin dynamics and enteric pathogens
McGuckin, M. A., Lindén, S. K., Sutton, P., & Florin, T. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2538 · Cited by 1,428
Helicobacter pylori: gastric cancer and beyond
Polk, D. B., & Peek, R. M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2857 · Cited by 1,158
Bacterial Adhesion and Entry into Host Cells
Pizarro-Cerdá, J., & Cossart, P. (2006) · Cell · doi:10.1016/j.cell.2006.02.012 · Cited by 977
“…of other Lewis antigens normally expressed at low levels such as sialylated sLe x and sLe a , and H. pylori recognizes these molecules via the sialic acid binding protein (SabA) (Mahdavi et al., 2002), suggesting that H. pylori infection favors the expression of its own receptors in target tissues.”
Metadata
- Authors
- Mahdavi, J., Sondén, B., Hurtig, M., Olfat, F. O., Forsberg, L., Roche, N., Ångström, J., Larsson, T., Teneberg, S., Karlsson, K.-A., Altraja, S., Wadström, T., Kersulyte, D., Berg, D. E., Dubois, A., Petersson, C., Magnusson, K.-E., Norberg, T., Lindh, F., Lundskog, B. B., Arnqvist, A., Hammarström, L., & Borén, T.
- Venue
- Science
- Published
- 2002-07-26
- Volume
- 297
- Issue
- 5581
- Pages
- 573-578
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2114798556
- Cited by
- 932
- References
- 2
- FWCI
- 36.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Mahdavi, J., Sondén, B., Hurtig, M., Olfat, F. O., Forsberg, L., Roche, N., Ångström, J., Larsson, T., Teneberg, S., Karlsson, K.-A., Altraja, S., Wadström, T., Kersulyte, D., Berg, D. E., Dubois, A., Petersson, C., Magnusson, K.-E., Norberg, T., Lindh, F., . . . Borén, T. (2002). Helicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation. Science. https://doi.org/10.1126/science.1069076
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
