The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
An Essential Role of N-Terminal Arginylation in Cardiovascular Development
Abstract
The enzymatic conjugation of arginine to the N-termini of proteins is a part of the ubiquitin-dependent N-end rule pathway of protein degradation. In mammals, three N-terminal residues—aspartate, glutamate, and cysteine—are substrates for arginylation. The mouse ATE1 gene encodes a family of Arg-tRNA-protein transferases (R-transferases) that mediate N-terminal arginylation. We constructed ATE1-lacking mouse strains and found that ATE1 −/− embryos die with defects in heart development and in angiogenic remodeling of the early vascular plexus. Through biochemical analyses, we show that N-terminal cysteine, in contrast to N-terminal aspartate and glutamate, is oxidized before its arginylation by R-transferase, suggesting that the arginylation branch of the N-end rule pathway functions as an oxygen sensor.
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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
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In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue
Bachmair, A., Finley, D., & Varshavsky, A. (1986) · Science · doi:10.1126/science.3018930 · Cited by 1,971
Self-citationThe N-end rule: functions, mysteries, uses
Varshavsky, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12142 · Cited by 859
Self-citationHershko, A., Ciechanover, A., & Varshavsky, A. (2000) · Nature Medicine · doi:10.1038/80384 · Cited by 649
Self-citationSin, N., Meng, L., Wang, M. Q. W., Wen, J. J., Bornmann, W. G., & Crews, C. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6099 · Cited by 635
Cohesin Cleavage by Separase Required for Anaphase and Cytokinesis in Human Cells
Hauf, S., Waizenegger, I. C., & Peters, J.-M. (2001) · Science · doi:10.1126/science.1061376 · Cited by 499
Universality and Structure of the N-end Rule
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Self-citationGriffith, E. C., Su, Z., Turk, B. E., Chen, S., Chang, Y.-H., Wu, Z., Biemann, K., & Liu, J. O. (1997) · Chemistry & Biology · doi:10.1016/s1074-5521(97)90198-8 · Cited by 421
Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability
Rao, H., Uhlmann, F., Nasmyth, K., & Varshavsky, A. (2001) · Nature · doi:10.1038/35073627 · Cited by 276
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Pickart, C. M. (2004) · Cell · doi:10.1016/s0092-8674(03)01074-2 · Cited by 697
N-degron and C-degron pathways of protein degradation
Varshavsky, A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816596116 · Cited by 544
Self-citationTasaki, T., Sriram, S. M., Park, K. S., & Kwon, Y. T. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051710-093308 · Cited by 386
Self-citationRedox Signaling by Reactive Electrophiles and Oxidants
Parvez, S., Long, M. J. C., Poganik, J. R., & Aye, Y. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00698 · Cited by 359
Protein Quality Control by Molecular Chaperones in Neurodegeneration
Ciechanover, A., & Kwon, Y. T. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00185 · Cited by 346
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Metadata
- Authors
- Kwon, Y. T., Kashina, A. S., Davydov, I. V., Hu, R.-G., An, J. Y., Seo, J. W., Du, F., & Varshavsky, A.
- Venue
- Science
- Published
- 2002-07-05
- Volume
- 297
- Issue
- 5578
- Pages
- 96-99
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021363994
- Cited by
- 349
- References
- 18
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kwon, Y. T., Kashina, A. S., Davydov, I. V., Hu, R.-G., An, J. Y., Seo, J. W., Du, F., & Varshavsky, A. (2002). An Essential Role of N-Terminal Arginylation in Cardiovascular Development. Science. https://doi.org/10.1126/science.1069531
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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