The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
A Role for Skin γδ T Cells in Wound Repair
Abstract
γδ T cell receptor–bearing dendritic epidermal T cells (DETCs) found in murine skin recognize antigen expressed by damaged or stressed keratinocytes. Activated DETCs produce keratinocyte growth factors (KGFs) and chemokines, raising the possibility that DETCs play a role in tissue repair. We performed wound healing studies and found defects in keratinocyte proliferation and tissue reepithelialization in the absence of wild-type DETCs. In vitro skin organ culture studies demonstrated that adding DETCs or recombinant KGF restored normal wound healing in γδ DETC-deficient skin. We propose that DETCs recognize antigen expressed by injured keratinocytes and produce factors that directly affect wound repair.
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Cites
T cell receptor antagonist peptides induce positive selection
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γδ Cells: A Right Time and a Right Place for a Conserved Third Way of Protection
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Self-citationLarge induction of keratinocyte growth factor expression in the dermis during wound healing
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The Function of KGF in Morphogenesis of Epithelium and Reepithelialization of Wounds
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Cited by
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Regulation of Wound Healing by Growth Factors and Cytokines
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Wound repair and regeneration: Mechanisms, signaling, and translation
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Inflammation in Wound Repair: Molecular and Cellular Mechanisms
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The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin
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Metadata
- Authors
- Jameson, J., Ugarte, K., Chen, N., Yachi, P., Fuchs, E., Boismenu, R., & Havran, W. L.
- Venue
- Science
- Published
- 2002-04-26
- Volume
- 296
- Issue
- 5568
- Pages
- 747-749
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1660648079
- Cited by
- 639
- References
- 23
- FWCI
- 27.32
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
