The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
γδ Cells: A Right Time and a Right Place for a Conserved Third Way of Protection
Abstract
The tripartite subdivision of lymphocytes into B cells, αβ T cells, and γδ cells has been conserved seemingly since the emergence of jawed vertebrates, more than 450 million years ago. Yet, while we understand much about B cells and αβ T cells, we lack a compelling explanation for the evolutionary conservation of γδ cells. Such an explanation may soon be forthcoming as advances in unraveling the biochemistry of γδ cell interactions are reconciled with the abnormal phenotypes of γδ-deficient mice and with the striking differences in γδ cell activities in different strains and species. In this review, the properties of γδ cells form a basis for understanding γδ cell interactions with antigens and other cells that in turn form a basis for understanding immunoprotective and regulatory functions of γδ cells in vivo. We conclude by considering which γδ cell functions may be most critical.
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Ferrick, D. A., Schrenzel, M. D., Mulvania, T., Hsieh, B., Ferlin, W. G., & Lepper, H. (1995) · Nature · doi:10.1038/373255a0 · Cited by 662
Ikuta, K., Kina, T., MacNeil, I., Uchida, N., Peault, B., Chien, Y.-H., & Weissman, I. L. (1990) · Cell · doi:10.1016/0092-8674(90)90262-d · Cited by 583
Intraepithelial T Cells of the TcRγ/δ+CD8− and Vδ1/Jδ1+ Phenotypes are Increased in Coeliac Disease
HALSTENSEN, T. S., SCOTT, H., & BRANDTZAEG, P. (1989) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1989.tb02474.x · Cited by 311
The Homeodomain Region of Rag-1 Reveals the Parallel Mechanisms of Bacterial and V(D)J Recombination
Spanopoulou, E., Zaitseva, F., Wang, F.-H., Santagata, S., Baltimore, D., & Panayotou, G. (1996) · Cell · doi:10.1016/s0092-8674(00)81344-6 · Cited by 225
The Generation of Human γδ T Cell Repertoires During Fetal Development
McVay, L. D., Jaswal, S. S., Kennedy, C., Hayday, A., & Carding, S. R. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.12.5851 · Cited by 85
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Cancer immunoediting: from immunosurveillance to tumor escape
Dunn, G. P., Bruce, A. T., Ikeda, H., Old, L. J., & Schreiber, R. D. (2002) · Nature Immunology · doi:10.1038/ni1102-991 · Cited by 5,393
Genomic analysis of the host response to hepatitis C virus infection
Su, A. I., Pezacki, J. P., Wodicka, L., Brideau, A. D., Supekova, L., Thimme, R., Wieland, S., Bukh, J., Purcell, R. H., Schultz, P. G., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202608199 · Cited by 1,161
γδ T cells: functional plasticity and heterogeneity
Carding, S. R., & Egan, P. J. (2002) · Nature Reviews Immunology · doi:10.1038/nri797 · Cited by 814
γδ T cells in tissue physiology and surveillance
Ribot, J. C., Lopes, N., & Silva-Santos, B. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00452-4 · Cited by 532
Intraepithelial lymphocytes: exploring the Third Way in immunology
Hayday, A., Theodoridis, E., Ramsburg, E., & Shires, J. (2001) · Nature Immunology · doi:10.1038/ni1101-997 · Cited by 491
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Metadata
- Authors
- Hayday, A. C.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2000-04
- Volume
- 18
- Issue
- 1
- Pages
- 975-1026
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2114951959
- Cited by
- 1,136
- References
- 5
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
