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Cited by 433

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Influence of Gene Action Across Different Time Scales on Behavior

Ben-Shahar, Y., Robichon, A., Sokolowski, M. B., Robinson, G. E.·2002·Science
DOI 10.1126/science.1069911
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Abstract

Genes can affect natural behavioral variation in different ways. Allelic variation causes alternative behavioral phenotypes, whereas changes in gene expression can influence the initiation of behavior at different ages. We show that the age-related transition by honey bees from hive work to foraging is associated with an increase in the expression of the foraging ( for ) gene, which encodes a guanosine 3′,5′-monophosphate (cGMP)–dependent protein kinase (PKG). cGMP treatment elevated PKG activity and caused foraging behavior. Previous research showed that allelic differences in PKG expression result in two Drosophila foraging variants. The same gene can thus exert different types of influence on a behavior.

Overview

Integrity signals

Registry

Crossref · 10.1126/science.1069911

Cites

17 of 17 references verified0 citation errors · 0 not checkable

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Verification

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Citations

Cites

Show all 17 references

Research works printed but not linked: 7

  1. G. E. Robinson Am. Nat. in press.
  2. T. D. Seeley Wisdom of the Hive (Harvard Univ. Press Cambridge MA 1997).
  3. To measure mRNA levels of Amfor in individual bee brains we used real-time qRT-PCR with TaqMan technology (ABI). Total brain RNA from an individual brain was isolated with the RNeasy mini kit (Qiagen). Reverse transcription was performed according to protocol (TaqMan Reverse Transcription Reagents kit ABI) with 100 ng of total RNA. PCR was performed with the default parameters of the ABI Prism 5700 sequence detector. PrimerExpress software (ABI) was used to design highly specific primers and probe for Amfor. Forward probe 5′-AATATAACTTCCGGTGCAACGTATT; reverse probe 5′-CGTTTGGATCACGGAAGAAAG; TaqMan probe (ABI) 5′-FAM6-AGGCGTGCCGCAGAAGGTCCA-TAMRA. Levels of Amfor were quantified relative to 18 S rRNA (ABI kit); there were no differences in 18 S rRNA levels between nurses and foragers (11). Each sample was analyzed in triplicate and each data point was calculated as the average of the three. Quantification was based on the number of PCR cycles (Ct) required to cross a threshold of fluorescence intensity using the 2 -ΔΔCt technique (ABI User Bulletin 2) described in (24). Identification of nurses and foragers was as in (25). Bees were collected into liquid nitrogen immediately upon identification so that mRNA measurements accurately reflected gene activity under natural conditions. Bees were stored at −80°C until brain dissection.
  4. 10.1002/1096-9861(20001113)427:2<274::AID-CNE8>3.0.CO;2-# · DOI
  5. Y.-C. Ding et al. Proc. Natl. Acad. Sci. U.S.A. 99 309 (2002).
  6. Francis S. H., et al., Mol. Pharmacol. 34, 506 (1988).
  7. E. O. Wilson Sociobiology (Belknap/Harvard Cambridge MA 1975).

Cited by

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Metadata

Authors
Ben-Shahar, Y., Robichon, A., Sokolowski, M. B., & Robinson, G. E.
Affiliations
  • Department of Entomology,
  • CESG/CNRS, Université de Bourgogne, 15 rue Hugues Picardet, Dijon 21000, France.
  • Department of Zoology, University of Toronto, 3359 Mississauga Road, Mississauga, Ontario L5L1C6, Canada.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2002-04-26
Volume
296
Issue
5568
Pages
741-744
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1069911
Cited by
433
References
17
Language
en

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CoChat. (2026). Citation check: Influence of Gene Action Across Different Time Scales on Behavior. https://app.cochat.ai/papers/10.1126/science.1069911
The paper
Ben-Shahar, Y., Robichon, A., Sokolowski, M. B., & Robinson, G. E. (2002). Influence of Gene Action Across Different Time Scales on Behavior. Science. https://doi.org/10.1126/science.1069911

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.