cGMP Signalling in the Mammalian Brain: Role in Synaptic Plasticity and Behaviour
Abstract
The second messenger cyclic guanosine 3',5'-monophosphate (cGMP) plays a crucial role in the control of cardiovascular and gastrointestinal homeostastis, but its effects on neuronal functions are less established. This review summarizes recent biochemical and functional data on the role of the cGMP signalling pathway in the mammalian brain, with a focus on the regulation of synaptic plasticity, learning, and other complex behaviours. Expression profiling, along with pharmacological and genetic manipulations, indicates important functions of nitric oxide (NO)-sensitive soluble guanylyl cyclases (sGCs), cGMP-dependent protein kinases (cGKs), and cGMP-regulated phosphodiesterases (PDEs) as generators, effectors, and modulators of cGMP signals in the brain, respectively. In addition, neuronal cGMP signalling can be transmitted through cyclic nucleotide-gated (CNG) or hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels. The canonical NO/sGC/cGMP/cGK pathway modulates long-term changes of synaptic activity in the hippocampus, amygdala, cerebellum, and other brain regions, and contributes to distinct forms of learning and memory, such as fear conditioning, motor adaptation, and object recognition. Behavioural studies indicate that cGMP signalling is also involved in anxiety, addiction, and the pathogenesis of depression and schizophrenia. At the molecular level, different cGK isoforms appear to mediate effects of cGMP on presynaptic transmitter release and postsynaptic functions. The cGKs have been suggested to modulate cytoskeletal organization, vesicle and AMPA receptor trafficking, and gene expression via phosphorylation of various substrates including VASP, RhoA, RGS2, hSERT, GluR1, G-substrate, and DARPP-32. These and other components of the cGMP signalling cascade may be attractive new targets for the treatment of cognitive impairment, drug abuse, and psychiatric disorders.
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For inducible NOS to kill microbes, parasites, or cancer cells, high levels of NO are needed to destroy FeS centers and respiratory proteins in the target organism.
“At the extreme of this spectrum, it is known that for inducible NOS to kill microbes, parasites, or cancer cells, high levels of NO are needed to destroy FeS centers and respiratory proteins in the target organism (28, 31, 32, 46).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [46]
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Groth, R. D., Coicou, L. G., Mermelstein, P. G., & Seybold, V. S. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04632.x · Cited by 52 · see citing works
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What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology
Hill, B. G., Dranka, B. P., Bailey, S. M., Lancaster, J. R., & Darley-Usmar, V. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.101618 · Cited by 310 · see citing works
Drugs of abuse and stress impair LTP at inhibitory synapses in the ventral tegmental area
Niehaus, J. L., Murali, M., & Kauer, J. A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07256.x · Cited by 140 · see citing works
Nitric oxide signalling and antidepressant action revisited
Joca, S. R. L., Sartim, A. G., Roncalho, A. L., Diniz, C. F. A., & Wegener, G. (2019) · Cell and Tissue Research · doi:10.1007/s00441-018-02987-4 · Cited by 63 · see citing works
- Authors
- Kleppisch, T., & Feil, R.
- Affiliations
- Technical University of Munich (DE)
- University of Tübingen (DE)
- Corresponding author
- Kleppisch, Thomas
- ORCID
- Feil, Robert
- Venue
- Handbook of Experimental Pharmacology
- Publisher
- Springer Berlin Heidelberg
- Published
- 2009
- Issue
- 191
- Pages
- 549-579
- ISSN
- 0171-2004 (ISSN-L)
- OpenAlex
- W190813598
- Cited by
- 161
- References
- 222
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 2 · 2019: 12 · 2018: 9 · 2017: 13 · 2016: 7 · 2015: 3 · 2014: 13 · 2013: 12 · 2012: 20
- FWCI
- 15.46
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Handbook of experimental pharmacology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- cGMP signaling, soluble guanylate cyclase, cGMP-dependent protein kinase, phosphodiesterase, nitric oxide, cyclic nucleotide-gated channels, HCN channels, synaptic plasticity, learning and memory, fear conditioning, anxiety, addiction, depression, schizophrenia, AMPA receptor trafficking, vesicle release, cytoskeletal organization, drug abuse, cognitive impairment, mental illness
- MeSH terms
- Animals, Brain, Gene Expression Regulation, Cyclic GMP, Humans, Synaptic Transmission, Neuronal Plasticity, Nitric Oxide, Signal Transduction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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