Cited by 606Memory and Neural MechanismsSpatial Cognition and NavigationNeurogenesis and neuroplasticity mechanisms

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Place Cells and Place Recognition Maintained by Direct Entorhinal-Hippocampal Circuitry

Brun, Vegard H., Otnæss, Mona K., Molden, Sturla, Steffenach, Hill-Aina, Witter, Menno P., Moser, May-Britt, Moser, Edvard I.·2002·Science

DOI 10.1126/science.1071089

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Abstract

Place cells in hippocampal area CA1 may receive positional information from the intrahippocampal associative network in area CA3 or directly from the entorhinal cortex. To determine whether direct entorhinal connections support spatial firing and spatial memory, we removed all input from areas CA3 to CA1, thus isolating the CA1 area. Pyramidal cells in the isolated CA1 area developed sharp and stable place fields. Rats with an isolated CA1 area showed normal acquisition of an associative hippocampal-dependent spatial recognition task. Spatial recall was impaired. These results suggest that the hippocampus contains two functionally separable memory circuits: The direct entorhinal-CA1 system is sufficient for recollection-based recognition memory, but recall depends on intact CA3-CA1 connectivity.

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K. Nakazawa et al. Science in press; published online 30 May 2002 (10.1126/science.1071795). · DOI
We thank R. Biegler and R. G. M. Morris for discussion and I. M. F. Hammer K. Haugen K. Jenssen and R. Ulriksen for technical assistance. Supported by the European Commission (Framework 5; QLG3-CT-1999-00192) and the Norwegian Research Council (139786/300 133958/420). Supporting Online Material www.sciencemag.org/cgi/content/full/296/5576/2243/DC1 Materials and Methods Fig. S1 Movie S1

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Authors: Brun, V. H., Otnæss, M. K., Molden, S., Steffenach, H.-A., Witter, M. P., Moser, M.-B., & Moser, E. I.
Affiliations: Norwegian University of Science and Technology (NO)
Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Corresponding author: Moser, Edvard I.
ORCID: Brun, Vegard H.
Witter, Menno P.
Moser, May-Britt
Moser, Edvard I.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2002-06-21
Volume: 296
Issue: 5576
Pages: 2243-2246
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1071089
OpenAlex: W2004974848
Cited by: 606
References: 24
Citations by year: 2026: 13 · 2025: 20 · 2024: 15 · 2023: 17 · 2022: 17 · 2021: 26 · 2020: 20 · 2019: 18 · 2018: 18 · 2017: 26 · 2016: 35 · 2015: 39 · 2014: 33 · 2013: 25 · 2012: 31
FWCI: 13.98
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Social Sciences › Psychology › Experimental and Cognitive Psychology › Spatial Cognition and Navigation
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: place cells, entorhinal cortex, hippocampal CA1, spatial memory, recollection
MeSH terms: Action Potentials, Animals, Brain Mapping, Denervation, Electrodes, Implanted, Hippocampus, Interneurons, Memory, Nerve Net, Neural Pathways, Mental Recall, Space Perception, Pyramidal Cells, Entorhinal Cortex, Maze Learning, Rats

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Place Cells and Place Recognition Maintained by Direct Entorhinal-Hippocampal Circuitry

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