Reversibility of object recognition but not spatial memory impairment following binge-like alcohol exposure in rats
Open accessAbstract
Excessive alcohol use leads to neurodegeneration in several brain structures including the hippocampal dentate gyrus and the entorhinal cortex. Cognitive deficits that result are among the most insidious and debilitating consequences of alcoholism. The object exploration task (OET) provides a sensitive measurement of spatial memory impairment induced by hippocampal and cortical damage. In this study, we examine whether the observed neurotoxicity produced by a 4-day binge ethanol treatment results in long-term memory impairment by observing the time course of reactions to spatial change (object configuration) and non-spatial change (object recognition). Wistar rats were assessed for their abilities to detect spatial configuration in the OET at 1 week and 10 weeks following the ethanol treatment, in which ethanol groups received 9-15 g/kg/day and achieved blood alcohol levels over 300 mg/dl. At 1 week, results indicated that the binge alcohol treatment produced impairment in both spatial memory and non-spatial object recognition performance. Unlike the controls, ethanol treated rats did not increase the duration or number of contacts with the displaced object in the spatial memory task, nor did they increase the duration of contacts with the novel object in the object recognition task. After 10 weeks, spatial memory remained impaired in the ethanol treated rats but object recognition ability was recovered. Our data suggest that episodes of binge-like alcohol exposure result in long-term and possibly permanent impairments in memory for the configuration of objects during exploration, whereas the ability to detect non-spatial changes is only temporarily affected.
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Certain aspects of HC-dependent learning and memory, such as spatial learning and memory, were not impacted following adolescent alcohol exposure but were in adults.
“Although there is evidence for persistent neurological and cognitive deficits in HC function, it is important to note that certain aspects of HC-dependent learning and memory, such as spatial learning and memory, were not impacted following adolescent exposure (Coleman et al. 2011; Vetreno and Crews 2012) but were in adults (Cippitelli et al. 2010).”
From The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse (2018) · cites this paper as Cippitelli et al. 2010
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- Authors
- Cippitelli, A., Zook, M., Bell, L., Damadzic, R., Eskay, R. L., Schwandt, M., & Heilig, M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Cippitelli, Andrea
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 94
- Issue
- 4
- Pages
- 538-546
- ISSN
- 1074-7427 (ISSN-L)
- PMC
- PMC2975859
- OpenAlex
- W1998864147
- Cited by
- 44
- References
- 53
- Citations by year
- 2026: 2 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 5
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Johns Hopkins University
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (ZIAAA000487)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
- Keywords
- binge ethanol, object recognition, spatial memory, hippocampal neurotoxicity, entorhinal cortex, alcoholism, memory impairment
- MeSH terms
- Alcohol Drinking, Ethanol, Analysis of Variance, Animals, Central Nervous System Depressants, Discrimination, Psychological, Disease Models, Animal, Exploratory Behavior, Male, Nerve Degeneration, Neurons, Reaction Time, Space Perception, Spatial Behavior, Time Factors, Cell Death, Rats, Wistar, Entorhinal Cortex, Dentate Gyrus, Recovery of Function, Recognition, Psychology, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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