The effects of oxytocin on cognitive defect caused by chronic restraint stress applied to adolescent rats and on hippocampal VEGF and BDNF levels
Open accessAbstract
BACKGROUND: Because brain development continues during adolescence, the effects of chronic stress on hippocampal changes that occur during that period are permanent. Oxytocin, which is synthesized in the hypothalamus and has many receptors in brain regions, including the hippocampus, may affect learning-memory. This study aimed to investigate chronic restraint stress on hippocampal functions, and hippocampal vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF) levels in adolescent male and female rats and the role of oxytocin in these effects. MATERIAL/METHODS: Experimental groups included control, stress+oxytocin, and stress+saline groups. Restraint stress was applied to all the stress groups for 1 h/day, for 7 days. Learning-memory tests were performed after the 7th day. RESULTS: In the stress+oxytocin groups, the process of finding the platform was shorter than in others groups. The stress+saline groups spent less time, whereas the stress+oxytocin groups spent more time, on the target quadrant in the probe trial. In the stress+oxytocin groups thigmotaxis time (indicating anxiety) decreased, but VEGF and BDNF levels increased. A positive correlation was found between VEGF and BDNF levels and the time spent within the target quadrant. CONCLUSIONS: The results indicate that impaired hippocampal learning and memory loss due to chronic restraint stress can be positively affected by intranasal oxytocin.
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OT can increase BDNF expression in hippocampus and neuroblastoma cells.
“It has been reported that OT can increase BDNF expression in hippocampus (72) and neuroblastoma cells (73), but otherwise little is known about OT-BDNF interactions.”
From Oxytocin receptors in the anteromedial bed nucleus of the stria terminalis promote stress-induced social avoidance in female California mice (2018) · cites this paper as [72]
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- Authors
- Uysal, N.
- Affiliations
- Dokuz Eylül University (TR)
- Corresponding author
- Uysal, Nazan
- ORCID
- Uysal, Nazan
- Venue
- Medical Science Monitor
- Published
- 2015
- Volume
- 21
- Pages
- 69-75
- ISSN
- 1234-1010 (ISSN-L)
- 1643-3750
- PMC
- PMC4294596
- OpenAlex
- W2089910600
- Cited by
- 44
- References
- 42
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 1
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Medical Science Monitor (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, chronic restraint stress, adolescent rats, hippocampus, vascular endothelial growth factor, brain-derived neurotrophic factor, learning and memory, anxiety, thigmotaxis, intranasal administration, sex differences
- MeSH terms
- Animals, Anxiety, Cognition Disorders, Female, Hippocampus, Hypothalamus, Learning, Male, Memory, Oxytocin, Rats, Wistar, Maze Learning, Brain-Derived Neurotrophic Factor, Vascular Endothelial Growth Factor A, Rats
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