Regulation of fatty acid and cholesterol synthesis: co-operation or competition?

Regulation of the mevalonate pathway

Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394 · see citing works

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092 · see citing works

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

Brown, M. S., & Goldstein, J. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80213-5 · Cited by 3,834 · see citing works

An oxysterol signalling pathway mediated by the nuclear receptor LXRα

Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R., & Mangelsdorf, D. J. (1996) · Nature · doi:10.1038/383728a0 · Cited by 1,754 · see citing works

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβPreprint

Repa, J. J., Liang, G., Ou, J., Bashmakov, Y. K., Lobaccaro, J. A., Shimomura, I., Shan, B., Brown, M. S., Goldstein, J. L., & Mangelsdorf, D. J. (2000) · Genes & Development · doi:10.1101/gad.844900 · Cited by 1,693 · see citing works

Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting

Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., & Wahli, W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6223 · Cited by 1,649 · see citing works

THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?

Hardie, D. G., Carling, D., & Carlson, M. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.821 · Cited by 1,436 · see citing works

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J. A., Hammer, R. E., & Mangelsdorf, D. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81432-4 · Cited by 1,428 · see citing works

A Linear Steady-State Treatment of Enzymatic Chains. General Properties, Control and Effector Strength

Heinrich, R., & Rapoport, T. A. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03318.x · Cited by 1,400 · see citing works

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

Brown, M. S., & Goldstein, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11041 · Cited by 1,327 · see citing works

Understanding the control of metabolism

(1997) · Choice Reviews Online · doi:10.5860/choice.34-6252 · Cited by 1,230 · see citing works

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

Wang, X., Sato, R., Brown, M. S., Hua, X., & Goldstein, J. L. (1994) · Cell · doi:10.1016/0092-8674(94)90234-8 · Cited by 1,003 · see citing works

Cholesterol, lipid rafts, and disease

Simons, K., & Ehehalt, R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16390 · Cited by 995 · see citing works

Crucial Step in Cholesterol Homeostasis

Yang, T., Espenshade, P. J., Wright, M. E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J. L., & Brown, M. S. (2002) · Cell · doi:10.1016/s0092-8674(02)00872-3 · Cited by 987 · see citing works

P EROXISOMAL β-O XIDATION AND P EROXISOME P ROLIFERATOR –A CTIVATED R ECEPTOR α: An Adaptive Metabolic System

Reddy, J. K., & Hashimoto, T. (2001) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.21.1.193 · Cited by 955 · see citing works

A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders

Leone, T. C., Weinheimer, C. J., & Kelly, D. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7473 · Cited by 943 · see citing works

Cholesterol, lipid rafts, and disease

Simons, K., & Ehehalt, R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216390 · Cited by 916 · see citing works

Isoprenoid biosynthesis: The evolution of two ancient and distinct pathways across genomes

Lange, B. M., Rujan, T., Martin, W., & Croteau, R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240454797 · Cited by 881 · see citing works

Lipotoxic diseases

Unger, R. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104057 · Cited by 875 · see citing works

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

Shimano, H., Horton, J. D., Hammer, R. E., Shimomura, I., Brown, M. S., & Goldstein, J. L. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118951 · Cited by 810 · see citing works

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

Shimomura, I., Bashmakov, Y. K., Ikemoto, S., Horton, J. D., Brown, M. S., & Goldstein, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13656 · Cited by 779 · see citing works

Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes

Shimano, H. (2001) · Progress in Lipid Research · doi:10.1016/s0163-7827(01)00010-8 · Cited by 758 · see citing works

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

Horton, J. D., Shimomura, I., Brown, M. S., Hammer, R. E., Goldstein, J. L., & Shimano, H. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2961 · Cited by 703 · see citing works

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice

Horton, J. D., Bashmakov, Y. K., Shimomura, I., & Shimano, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.5987 · Cited by 669 · see citing works

The control of flux

KACSER, H., Burns, J., KACSER, H., & Fell, D. A. (1995) · Biochemical Society Transactions · doi:10.1042/bst0230341 · Cited by 576 · see citing works

ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose

Foretz, M., Pacot, C., Dugail, I., Lemarchand, P., Guichard, C., Lièpvre, X. L., Lubrano-Berthelier, C., Spiegelman, B. M., Kim, J. B., Ferré, P., et al. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3760 · Cited by 548 · see citing works

Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action

Osborne, T. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000017200 · Cited by 521 · see citing works

Overproduction of Acetyl-CoA Carboxylase Activity Increases the Rate of Fatty Acid Biosynthesis in Escherichia coli

Davis, M. S., Solbiati, J., & Cronan, J. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004756200 · Cited by 479 · see citing works

Peroxisome proliterator-activated receptor-alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis

Fruchart, J.-C., Duriez, P., & Staels, B. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199906000-00007 · Cited by 425 · see citing works

Cholesterol Addition to ER Membranes Alters Conformation of SCAP, the SREBP Escort Protein that Regulates Cholesterol Metabolism

Brown, A. J., Sun, L., Feramisco, J. D., Brown, M. S., & Goldstein, J. L. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00591-9 · Cited by 417 · see citing works

REGULATION OF MAMMALIAN ACETYL-COENZYME A CARBOXYLASE

Kim, K.-H. (1997) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.17.1.77 · Cited by 394 · see citing works

Do sterols reduce proton and sodium leaks through lipid bilayers?

Haines, T. H. (2001) · Progress in Lipid Research · doi:10.1016/s0163-7827(01)00009-1 · Cited by 387 · see citing works

A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids

Yahagi, N., Shimano, H., Hasty, A. H., Amemiya-Kudo, M., Okazaki, H., Tamura, Y., Iizuka, Y., Shionoiri, F., Ohashi, K., Osuga, J.-I., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.50.35840 · Cited by 364 · see citing works

Regulated Step in Cholesterol Feedback Localized to Budding of SCAP from ER Membranes

Nohturfft, A., Yabe, D., Goldstein, J. L., Brown, M. S., & Espenshade, P. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00037-4 · Cited by 347 · see citing works

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevationPreprint

Matsuda, M., Korn, B. S., Hammer, R. E., Moon, Y.-A., Komuro, R., Horton, J. D., Goldstein, J. L., Brown, M. S., & Shimomura, I. (2001) · Genes & Development · doi:10.1101/gad.891301 · Cited by 338 · see citing works

Sterol Regulation of Fatty Acid Synthase Promoter

Bennett, M. K., López, J. M., Sanchez, H. B., & Osborne, T. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.43.25578 · Cited by 336 · see citing works

Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in <i>Drosophila</i>

Dobrosotskaya, I. Y., Seegmiller, A. C., Brown, M. S., Goldstein, J. L., & Rawson, R. B. (2002) · Science · doi:10.1126/science.1071124 · Cited by 318 · see citing works

Regulation of gene expression by SREBP and SCAP

Edwards, P. A. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00140-2 · Cited by 316 · see citing works

The Microbial Origin of Fossil Fuels

Ourisson, G., Albrecht, P., & Rohmer, M. (1984) · Scientific American · doi:10.1038/scientificamerican0884-44 · Cited by 309 · see citing works

Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states.

Brown, M. S., Goldstein, J. L., & Dietschy, J. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50571-8 · Cited by 308 · see citing works

Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver.

Sheng, Z., Otani, H., Brown, M. S., & Goldstein, J. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.4.935 · Cited by 302 · see citing works

STUDIES ON THE SITE OF THE FEEDBACK CONTROL OF CHOLESTEROL SYNTHESIS*†

Siperstein, M. D., & Guest, M. J. (1960) · Journal of Clinical Investigation · doi:10.1172/jci104079 · Cited by 273 · see citing works

Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid.

López, J. M., Bennett, M. K., Sanchez, H. B., Rosenfeld, J. M., & Osborne, T. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1049 · Cited by 262 · see citing works

Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP‐activated protein kinase

Henin, N., Vincent, M. F., Gruber, H. E., & Berghe, G. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.7.7737463 · Cited by 251 · see citing works

3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

Brown, M. S., Dana, S. E., Dietschy, J. M., & Siperstein, M. D. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43725-3 · Cited by 234 · see citing works

Regulation of rates of cholesterol synthesis in vivo in the liver and carcass of the rat measured using [3H]water

Jeske, D. J., & Dietschy, J. M. (1980) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39816-3 · Cited by 231 · see citing works

Regulation of Cholesterol Biosynthesis in Normal and Malignant Tissues

(1970) · Current topics in cellular regulation · doi:10.1016/b978-0-12-152802-7.50009-8 · Cited by 227 · see citing works

ON THE UTILIZATION OF ACETIC ACID FOR CHOLESTEROL FORMATION

Bloch, K., & Rittenberg, D. (1942) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51303-x · Cited by 195 · see citing works

The SREBP Pathway in Drosophila

Seegmiller, A. C., Dobrosotskaya, I., Goldstein, J. L., Ho, Y. K., Brown, M. S., & Rawson, R. B. (2002) · Developmental Cell · doi:10.1016/s1534-5807(01)00119-8 · Cited by 194 · see citing works

Cholesterol in health and disease

Tabas, I. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216381 · Cited by 190 · see citing works

CHOLESTEROL METABOLISM

Gould, R. G., TAYLOR, C. B., Hagerman, J. S., Warner, I., & Campbell, D. J. (1953) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66206-4 · Cited by 189 · see citing works

Cholesterol and other membrane active sterols: from membrane evolution to “rafts”

Barenholz, Y. (2002) · Progress in Lipid Research · doi:10.1016/s0163-7827(01)00016-9 · Cited by 182 · see citing works

Cholesterol in health and disease

Tabas, I. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16381 · Cited by 167 · see citing works

Effect of alterations of the specific activity of the intracellular acetyl CoA pool on apparent rates of hepatic cholesterogenesis

Dietschy, J. M., & Brown, M. S. (1974) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)36771-7 · Cited by 162 · see citing works

Absolute rates of cholesterol synthesis in extrahepatic tissues measured with 3H-labeled water and 14C-labeled substrates.

Andersen, J. M., & Dietschy, J. (1979) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40027-6 · Cited by 156 · see citing works

Regulation of Hepatic 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

McNamara, D. J., Quackenbush, F. W., & Rodwell, V. W. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44829-1 · Cited by 154 · see citing works

Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver

Shimomura, I., Bashmakov, Y. K., Shimano, H., Horton, J. D., Goldstein, J. L., & Brown, M. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12354 · Cited by 151 · see citing works

Peroxisome-proliferator-activated receptor-α (PPARα) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin

Sugden, M. C., Bulmer, K., Gibbons, G. F., Knight, B. L., & Holness, M. J. (2002) · Biochemical Journal · doi:10.1042/bj20011699 · Cited by 149 · see citing works

Limitations of Acetate as a Substrate for Measuring Cholesterol Synthesis in Liver

Dietschy, J. M., & McGarry, J. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43089-5 · Cited by 142 · see citing works

Disturbances in the normal regulation of SREBP-sensitive genes in PPARα-deficient mice

Patel, D. D., Knight, B. L., Wiggins, D. K., Humphreys, S. M., & Gibbons, G. F. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31655-2 · Cited by 142 · see citing works

In vitro reversal of the fasting state of liver metabolism in the rat. Reevaluation of the roles of insulin and glucose.

Boyd, M. E., Albright, E. B., Foster, D. W., & McGarry, J. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110230 · Cited by 141 · see citing works

Role of the Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase Signaling Pathway in Insulin-Induced Expression of Sterol Regulatory Element Binding Protein 1c and Glucokinase Genes in Rat Hepatocytes

Matsumoto, M., Ogawa, W., Teshigawara, K., Inoue, H., Miyake, K., Sakaue, H., & Kasuga, M. (2002) · Diabetes · doi:10.2337/diabetes.51.6.1672 · Cited by 138 · see citing works

Adenovirus-Mediated Overexpression of Sterol Regulatory Element Binding Protein-1c Mimics Insulin Effects on Hepatic Gene Expression and Glucose Homeostasis in Diabetic Mice

Bécard, D., Hainault, I., Azzout‐Marniche, D., Bertry-Coussot, L., Ferré, P., & Foufelle, F. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2425 · Cited by 133 · see citing works

Interactions between metabolism and intracellular distribution of cholesterol and sphingomyelin

Ridgway, N. D. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00006-8 · Cited by 131 · see citing works

Biochemistry of Cholesterol

Gibbons, G. F., Mitropoulos, K. A., & Myant, N. B. (1982) · Medical Entomology and Zoology · Cited by 118 · see citing works

Acetyl-CoA carboxylase exerts strong flux control over lipid synthesis in plants

Page, R., Okada, S., & Harwood, J. L. (1994) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(94)90242-9 · Cited by 115 · see citing works

13C NMR of Intermediary Metabolism: Implications for Systemic Physiology

Shulman, R. G., & Rothman, D. L. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.15 · Cited by 108 · see citing works

Reflections on Biochemistry

(1976) · Elsevier eBooks · doi:10.1016/c2013-0-02804-6 · Cited by 106 · see citing works

Proteolysis and Sterol Regulation

Hampton, R. Y. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.032002.131219 · Cited by 104 · see citing works

Sterol Regulatory Element-binding Protein-1c Mimics the Negative Effect of Insulin on Phosphoenolpyruvate Carboxykinase (GTP) Gene Transcription

Chakravarty, K., Leahy, P. S., Bécard, D., Hakimi, P., Foretz, M., Ferré, P., Foufelle, F., & Hanson, R. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103310200 · Cited by 92 · see citing works

Modelling approaches in biomechanics

Alexander, R. M. (2003) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2003.1336 · Cited by 90 · see citing works

Regulation of Acetyl-CoA Carboxylase

Kim, K.-H. (1983) · Current topics in cellular regulation · doi:10.1016/b978-0-12-152822-5.50009-9 · Cited by 84 · see citing works

The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP

Janowski, B. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202471599 · Cited by 79 · see citing works

The effect of (−)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2

Berkhout, T. A., Havekes, L. M., Pearce, N. J., & Groot, P. H. E. (1990) · Biochemical Journal · doi:10.1042/bj2720181 · Cited by 79 · see citing works

Oleate Potentiates Oxysterol Inhibition of Transcription from Sterol Regulatory Element-1-regulated Promoters and Maturation of Sterol Regulatory Element-binding Proteins

Thewke, D. P., Panini, S. R., & Sinensky, M. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.21402 · Cited by 76 · see citing works

Koch's postulates for cholesterol

Brown, M. S., & Goldstein, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90346-e · Cited by 74 · see citing works

The sterols of some marine red algae

Gibbons, G. F. (1967) · Phytochemistry · doi:10.1016/s0031-9422(00)86007-0 · Cited by 72 · see citing works

The role of multiple enzyme activation in metabolic flux control

Thomas, S., & Fell, D. A. (1998) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(97)00012-5 · Cited by 68 · see citing works

Co‐expression of native and introduced genes reveals cryptic regulation of HMG CoA reductase expression in Arabidopsis

Re, E. B., Jones, D., & Learned, R. M. (1995) · The Plant Journal · doi:10.1046/j.1365-313x.1995.07050771.x · Cited by 67 · see citing works

Fuel selection and carbon flux during the starved-to-fed transition

Sugden, M. C., Holness, M. J., & Palmer, T. N. (1989) · Biochemical Journal · doi:10.1042/bj2630313 · Cited by 67 · see citing works

Diurnal changes in the fraction of 3-hydroxy-3-methylglutaryl-CoA reductase in the active form in rat liver microsomal fractions

Easom, R. A., & Zammit, V. A. (1984) · Biochemical Journal · doi:10.1042/bj2200739 · Cited by 60 · see citing works

Isolation and characterization of a mammalian cell mutant defective in 3-hydroxy-3-methylglutaryl coenzyme A synthase.

Schnitzer‐Polokoff, R., von Gunten, C. F., Logel, J., Torget, R. W., & Sinensky, M. S. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68388-2 · Cited by 57 · see citing works

Effect of sterol depletion on LM cell sterol mutants. Changes in the lipid composition of the plasma membrane and their effects on 3-O-methlglucose transport.

Baldassare, J. J., Saito, Y., & Silbert, D. F. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34174-1 · Cited by 53 · see citing works

Membrane phospholipid alterations in response to sterol depletion of LM cells. Metabolic studies.

Freter, C. E., Ladenson, R. C., & Silbert, D. F. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50261-1 · Cited by 52 · see citing works

The actions of cyclic AMP on biosynthetic processes are mediated indirectly by cyclic AMP-dependent protein kinase

Cohen, P., & Hardie, D. G. (1991) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(91)90089-g · Cited by 50 · see citing works

Regulation of cholesterol synthesis in the liver and mammary gland of the lactating rat

Gibbons, G. F., Pullinger, C. R., Munday, M. R., & Williamson, D. H. (1983) · Biochemical Journal · doi:10.1042/bj2120843 · Cited by 47 · see citing works

Beyond genomics

Fell, D. A. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02521-5 · Cited by 44 · see citing works

Selective Proteolytic Processing of Rat Hepatic Sterol Regulatory Element Binding Protein-1 (SREBP-1) and SREBP–2 During Postnatal Development

Botolin, D., & Jump, D. Β. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212846200 · Cited by 41 · see citing works

Evidence that changes in hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity are required partly to maintain a constant rate of sterol synthesis.

Gibbons, G. F., Björnsson, O. G., & Pullinger, C. R. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42613-5 · Cited by 37 · see citing works

The role of substrate supply in the regulation of cholesterol biosynthesis in rat hepatocytes

Pullinger, C. R., & Gibbons, G. F. (1983) · Biochemical Journal · doi:10.1042/bj2100625 · Cited by 35 · see citing works

LM cell growth and membrane lipid adaptation to sterol structure.

Rujanavech, C., & Silbert, D. F. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38374-6 · Cited by 34 · see citing works

Quantification of apolipoprotein B-48 and B-100 in rat liver endoplasmic reticulum and Golgi fractions

Cartwright, I. J., & Higgins, J. A. (1992) · Biochemical Journal · doi:10.1042/bj2850153 · Cited by 34 · see citing works

Sterol-regulatory-element-binding protein I c mediates insulin action on hepatic gene expression

Ferré, P., Foretz, M., Azzout‐Marniche, D., Bécard, D., & Foufelle, F. (2001) · Biochemical Society Transactions · doi:10.1042/bst0290547 · Cited by 33 · see citing works

Analysis of the coordinate expression of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities in Chinese hamster ovary fibroblasts

Schnitzer‐Polokoff, R., Torget, R. W., Logel, J., & Sinensky, M. S. (1983) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(83)90348-x · Cited by 29 · see citing works

Separation of the Intracellular Secretory Compartment of Rat Liver and Isolated Rat Hepatocytes in a Single Step Using Self-Generating Gradients of Iodixanol

Plonné, D., Cartwright, I. J., Linß, W., Dargel, R., Graham, J. M., & Higgins, J. A. (1999) · Analytical Biochemistry · doi:10.1006/abio.1999.4311 · Cited by 26 · see citing works

Identification of a cholesterol-regulated 53,000-dalton cytosolic protein in UT-1 cells and cloning of its cDNA.

Luskey, K. L., Chin, D. J., MacDonald, R. J., Liscum, L., Goldstein, J. L., & Brown, M. S. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.20.6210 · Cited by 26 · see citing works

Changes in the sensitivity of lipogenesis in rat hepatocytes to hormones and precursors over the diurnal cycle and during longer-term starvation of donor animals.

Gibbons, G. F., Pullinger, C. R., & Björnsson, Ó. G. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34453-9 · Cited by 24 · see citing works

Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme a synthase and the regulation of sterol synthesis in tissue culture cells

Ramachandran, C. K., Gray, S. L., & Melnykovych, G. (1980) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(80)90262-3 · Cited by 24 · see citing works

The functional efficiency of lipogenic and cholesterogenic gene expression in normal mice and in mice lacking the peroxisomal proliferator-activated receptor–alpha (PPAR–α)

Gibbons, G. F., Patel, D., Wiggins, D. K., & Knight, B. L. (2002) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(01)00033-4 · Cited by 22 · see citing works

Perinatal development of hepatic cholesterol synthesis in the rat

Haave, N., & Innis, S. M. (1991) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(91)90229-b · Cited by 15 · see citing works

Sterol Biosynthesis: The Early Days

Cornforth, J. W. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.2006 · Cited by 14 · see citing works

A biphasic effect of exogenous oleate on the rate of cholesterol biosynthesis by rat hepatocytes

Pullinger, C. R., & Gibbons, G. F. (1981) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(81)91709-5 · Cited by 10 · see citing works

Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation

Dong, X. C., Copps, K. D., Guo, S., Li, Y., Kollipara, R., DePinho, R. A., & White, M. F. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.006 · Cited by 463 · see citing works

THE MEVALONATE PATHWAY AND THE SYNTHESIS OF JUVENILE HORMONE IN INSECTS

Bellés, X., Martı́n, D., & Piulachs, M. (2004) · Annual Review of Entomology · doi:10.1146/annurev.ento.50.071803.130356 · Cited by 432 · see citing works

The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target

Abu‐Farha, M., Thanaraj, T. A., Qaddoumi, M. G., Hashem, A. M., Abubaker, J. A., & Al‐Mulla, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103544 · Cited by 301 · see citing works

A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP

Kamisuki, S., Mao, Q., Abu-Elheiga, L. A., Gu, Z., Kugimiya, A., Kwon, Y., Shinohara, T., Kawazoe, Y., Sato, S., Asakura, K., et al. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.07.007 · Cited by 282 · see citing works

Systems biology of lipid metabolism: From yeast to human

Nielsen, J. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.054 · Cited by 119 · see citing works

The Role of Dietary Cholesterol in Lipoprotein Metabolism and Related Metabolic Abnormalities: A Mini-review

Kapourchali, F. R., Gangadaran, S., Goulet, A., & Moghadasian, M. H. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.842887 · Cited by 103 · see citing works

Interactions between limiting nutrients: Consequences for somatic and population growth of Daphnia magna

Martin‐Creuzburg, D., Wacker, A., & Basen, T. (2010) · Limnology and Oceanography · doi:10.4319/lo.2010.55.6.2597 · Cited by 99 · see citing works

Genomic analysis of metabolic pathway gene expression in mice

Ghazalpour, A., Doss, S., Sheth, S. S., Ingram-Drake, L. A., Schadt, E. E., Lusis, A. J., & Drake, T. A. (2005) · Genome biology · doi:10.1186/gb-2005-6-7-r59 · Cited by 84 · see citing works

The evolution of plasma cholesterol: Direct utility or a “spandrel” of hepatic lipid metabolism?

Babin, P. J., & Gibbons, G. F. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.11.002 · Cited by 78 · see citing works

Proteomics in Myzus persicae: Effect of aphid host plant switch

Francis, F., Gerkens, P., Harmel, N., Mazzucchelli, G., Pauw, E. D., & Haubruge, É. (2006) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2006.01.018 · Cited by 77 · see citing works

Prospects of yeast systems biology for human health: integrating lipid, protein and energy metabolism

Petranović, D., Tyo, K. E. J., Vemuri, G. N., & Nielsen, J. (2010) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2010.00689.x · Cited by 65 · see citing works

Integrating expression profiling and whole-genome association for dissection of fat traits in a porcine model

Ponsuksili, S., Muráni, E., Brand, B., Schwerin, M., & Wimmers, K. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m013342 · Cited by 64 · see citing works

Effects of Rice Proteins from Two Cultivars,KoshihikariandShunyo, on Cholesterol and Triglyceride Metabolism in Growing and Adult Rats

Yang, L., Kumagai, T., Kawamura, H., Watanabe, T., Kubota, M., Fujimura, S., Watanabe, R., & Kadowaki, M. (2007) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.60480 · Cited by 61 · see citing works

Rice protein improves adiposity, body weight and reduces lipids level in rats through modification of triglyceride metabolism

Yang, L., Chen, J.-H., Lv, J., Wu, Q., Xu, T., Zhang, H., Liu, Q., & Yang, H.-K. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-24 · Cited by 56 · see citing works

Quantification of statin effects on hepatic cholesterol synthesis by transient 13C-flux analysis

Maier, K., Hofmann, U., Bauer, A., Niebel, A., Vacun, G., Reuß, M., & Mauch, K. (2009) · Metabolic Engineering · doi:10.1016/j.ymben.2009.06.001 · Cited by 50 · see citing works

Effects of Long-Term Dietary Protein Restriction on Intestinal Morphology, Digestive Enzymes, Gut Hormones, and Colonic Microbiota in Pigs

Yu, D., Zhu, W., & Hang, S. (2019) · Animals · doi:10.3390/ani9040180 · Cited by 50 · see citing works

Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells

Wu, T., Tian, J. Y., Cutler, R. G., Telljohann, R. S., Bernlohr, D., Mattson, M. P., & Handa, J. T. (2009) · Laboratory Investigation · doi:10.1038/labinvest.2009.33 · Cited by 44 · see citing works

Protective Effects of Emodin on Oxidized Fish Oil-Induced Metabolic Disorder and Oxidative Stress through Notch-Nrf2 Crosstalk in the Liver of Teleost Megalobrama amblycephala

Song, C., Liu, B., Liu, B., Tang, Y., Ge, X., Liu, B., & Xu, P. (2022) · Antioxidants · doi:10.3390/antiox11061179 · Cited by 40 · see citing works

Influence of Western diet and APOE genotype on Alzheimer's disease risk

Sullivan, P. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104790 · Cited by 25 · see citing works

Suppression of brain cholesterol synthesis in male Mecp2-deficient mice is age dependent and not accompanied by a concurrent change in the rate of fatty acid synthesis

Lopez, A. M., Chuang, J.-C., Posey, K. S., & Turley, S. D. (2017) · Brain Research · doi:10.1016/j.brainres.2016.10.021 · Cited by 24 · see citing works

Regulation of Connexin-Based Channels by Fatty Acids

Puebla, C., Retamal, M. A., Acuña, R. A., & Sáez, J. C. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00011 · Cited by 23 · see citing works

FoxO transcription factors are required for hepatic HDL cholesterol clearance

Lee, S. X., Heine, M., Schlein, C., Ramakrishnan, R., Liu, J., Belnavis, G., Haimi, I., Fischer, A. W., Ginsberg, H. N., Heeren, J., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci94230 · Cited by 21 · see citing works

Specifically blocking the fatty acid synthesis to inhibit the malignant phenotype of bladder cancer

Li, A., Yao, L., Fang, Y., Yang, K., Jiang, W. H., Huang, W., & Cai, Z. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.32518 · Cited by 21 · see citing works

Demonstration of diet-induced decoupling of fatty acid and cholesterol synthesis by combining gene expression array and2H2O quantification

Jensen, K. K., Previs, S. F., Zhu, L., Herath, K. B., Wang, S., Bhat, G., Hu, G., Miller, P. L., McLaren, D. G., Shin, M. K., et al. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00436.2011 · Cited by 21 · see citing works

Distinct cholesterogenic and lipidogenic gene expression patterns in ovarian cancer - a new pool of biomarkers

Pampalakis, G., Politi, A.-L., Papanastasiou, A. D., & Sotiropoulou, G. (2015) · Genes & Cancer · doi:10.18632/genesandcancer.87 · Cited by 20 · see citing works

Fatty acids: Metabolism

Watkins, P. A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-375083-9.00103-3 · Cited by 18 · see citing works

Deficiency of PPARα disturbs the response of lipogenic flux and of lipogenic and cholesterogenic gene expression to dietary cholesterol in mouse white adipose tissue

Islam, K., Knight, B. L., Frayn, K. N., Patel, D., & Gibbons, G. F. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.03.009 · Cited by 16 · see citing works

Promoter analysis of the murine squalene epoxidase gene. Identification of a 205 bp homing region regulated by both SREBP'S and NF-Y

Murphy, C., Ledmyr, H., Ehrenborg, E., & Gåfvels, M. E. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.08.015 · Cited by 14 · see citing works

Fatty Acids and Antioxidants in Reindeer and Red Deer Emphasis on Animal Nutrition and Consequent Meat Quality

Sampels, S. (2005) · Cited by 12 · see citing works

Health and Nutritional Benefits of Fish as Human Food

Singh, R. D., Arambam, K., Singh, A. M., & Singh, S. K. (2024) · Springer eBooks · doi:10.1007/978-3-031-75830-0_3 · Cited by 11 · see citing works

DHCR24 inhibitor SH42 increases desmosterol without preventing atherosclerosis development in mice

Ge, X., Slütter, B., Lambooij, J. M., Zhou, E., Ying, Z., Agirman, C., Heijink, M., Rimbert, A., Guigas, B., Kuiper, J., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109830 · Cited by 10 · see citing works

Lipid nanoparticle encapsulated oleic acid induced lipotoxicity to hepatocytes via ROS overload and the DDIT3/BCL2/BAX/Caspases signaling in vitro and in vivo

Liu, Y., Zhu, H., Li, T.-Y., Yang, X., Li, X.-J., & Zhang, W. K. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.06.024 · Cited by 9 · see citing works

Refining sugar's involvement in cholesterol synthesis

Fenton, N., Nguyen, T. B., Sharpe, L. J., & Brown, A. J. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159266 · Cited by 5 · see citing works

Fabp5 is a common gene between a high-cholesterol diet and acute pancreatitis

Qiu, M., Cai, F., Huang, Y., Sun, L., Li, J., Wang, W., Basharat, Z., Zippi, M., Goyal, H., Pan, J., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1284985 · Cited by 4 · see citing works

Differential effects of egg consumption on fecal lipid metabolism: Insights from C57BL/6J mice under chow diet and high-fat diet

Zhang, F., Yang, T., Li, J., Gu, L., Chang, C., Yang, L., Huang, Z., Su, Y., & Yang, Y. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104330 · Cited by 4 · see citing works

Fatty acids and antioxidants in reindeer and red deer

Sampels, S. (2005) · Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences)) · Cited by 4 · see citing works

Differential regulation of cholesterol homeostasis in transgenic mice expressing human cholesterol ester transfer proteinThis paper is one of a selection of papers published in this Special Issue, entitled The Cellular and Molecular Basis of Cardiovascular Dysfunction, Dhalla 70th Birthday Tribute.

Agarwal-Mawal, A., Murray, C. M., Belkhode, S. L., & Cheema, S. K. (2007) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y07-019 · Cited by 3 · see citing works

Cholesterol and highly unsaturated fatty acids: Exploring their synergistic roles in growth and lipid metabolism of juvenile Chinese mitten crab (Eriocheir sinensis)

Yu, Q., Wang, S., Li, E., Liu, S., Jiang, Z., Wang, X., Qin, J. G., & Chen, L. (2025) · Aquaculture Reports · doi:10.1016/j.aqrep.2025.103091 · Cited by 2 · see citing works

Xanthine oxidase activity in Pig’s blood and oxidative stress assay

Дементьев, А. В. (2013) · Russian Agricultural Sciences · doi:10.3103/s1068367413010059 · Cited by 2 · see citing works

Presence and titer of methyl palmitate in the Medfly (Ceratitis capitata) during reproductive maturation

Herman, T., Miloslavski, I., Aizenshtat, Z., & Applebaum, S. W. (2005) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2005.02.004 · Cited by 2 · see citing works

FATTY ACIDS | Metabolism

Watkins, P. A. (2004) · Elsevier eBooks · doi:10.1016/b0-12-226694-3/00115-0 · Cited by 2 · see citing works

Fatty acids: Metabolism

Watkins, P. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821848-8.00184-0 · Cited by 2 · see citing works

Effects of a fishmeal-free diet on growth, bile acids, and cholesterol metabolism in yearling red sea bream Pagrus major during low- to optimum-water temperature periods

Takakuwa, F., Murashita, K., Yoshinaga, H., Iizuka, T., Asakura, T., Yasuike, M., Shiraishi, S., Mineyama, N., Ukei, J., & Shioji, M. (2026) · Aquaculture Reports · doi:10.1016/j.aqrep.2026.103443 · Cited by 1 · see citing works

Fish Lipids Functionality in Health and Disease

Lokuruka, M. (2022) · Asian Food Science Journal · doi:10.9734/afsj/2022/v21i12605 · Cited by 1 · see citing works

Effect of Xylazine-Thiopental Anesthesia on Canine Fatty Acid Profiles

Ünsaldı, S., Kılıç, S., Yılmaz, Ö., & İşler, C. T. (2009) · DergiPark (Istanbul University) · Cited by 1 · see citing works

Biologia molecular de genes envolvidos no metabolismo do hormônio juvenil em Apis mellifera

dos Santos, A. M. (2008) · doi:10.11606/t.17.2008.tde-25052011-162352

Inflammatory demyelination could be attributed to nitric oxide inhibition of cytosolic CoA with failed lipogenesis

Roediger, W. E. W., & Gibbons, G. F. (2005) · Journal of Neurology · doi:10.1007/s00415-005-0869-x

Lipid Microdomains in Insulin Receptor Signalling

Vainio, S. (2006) · Työväentutkimus Vuosikirja

Changes of Leptin, Leptin Receptor and Fatty Acids During Chemoradiotherapy in Patients with Esophageal Cancer

Haluzı́k, M., & Novak, F. J. (2005)

Lipid-gene interactions, diet and health

Lairon, D., & Planells, R. (2006) · Elsevier eBooks · doi:10.1533/9781845691073.1.49

Cholesterol: an ancient ally or modern menace?

Luna-Reyes, I., Villa-Jaimes, S., Calixto-Tlacomulco, S., Pérez-Hernández, E. G., Montalvan‐Sorrosa, D., Reyes‐Grajeda, J. P., & Mas‐Oliva, J. (2026) · Royal Society Open Science · doi:10.1098/rsos.250853

Differential effects of saturated fatty acid, monounsaturated fatty acid and polyunsaturated fatty acid on chylomicron metabolism in the small intestine

Galloway, S., Cheung, C. C. K., Takechi, R., Pallebage‐Gamarallage, M. M., & Mamo, J. C. L. (2008) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2008.09.402 · Cited by 1 · see citing works

Cholesterol synthesis and fatty acid synthesis may be inversely regulated in rat mammary acini

SMITH, R. A. W., Middleton, B., & West, D. W. (1986) · Biochemical Society Transactions · doi:10.1042/bst0140901 · Cited by 2 · see citing works

Recent advances in regulating cholesterol and bile acid metabolism

Sato, R. (2020) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2020.1793658 · Cited by 26 · see citing works

Cholesterol synthesis

Brown, A. J., Coates, H. W., & Sharpe, L. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-824048-9.00005-5 · Cited by 26 · see citing works

Regulation of Fatty Acid Biosynthesis by Intermediates of the Cholesterol Biosynthetic Pathway

Ku, E. C. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1149 · Cited by 6 · see citing works