The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Biosynthesis of the Enediyne Antitumor Antibiotic C-1027
Abstract
C-1027 is a potent antitumor agent with a previously undescribed molecular architecture and mode of action. Cloning and characterization of the 85-kilobase C-1027 biosynthesis gene cluster from Streptomyces globisporus revealed (i) an iterative type I polyketide synthase that is distinct from any bacterial polyketide synthases known to date, (ii) a general polyketide pathway for the biosynthesis of both the 9- and 10-membered enediyne antibiotics, and (iii) a convergent biosynthetic strategy for the C-1027 chromophore from four building blocks. Manipulation of genes governing C-1027 biosynthesis allowed us to produce an enediyne compound in a predicted manner.
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Cites
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Cited by
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Self-citationNatural Products Version 2.0: Connecting Genes to Molecules
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Natural‐Product Sugar Biosynthesis and Enzymatic Glycodiversification
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Tryptophan 7-Halogenase (PrnA) Structure Suggests a Mechanism for Regioselective Chlorination
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Metadata
- Authors
- Liu, W., Christenson, S. D., Standage, S., & Shen, B.
- Venue
- Science
- Published
- 2002-08-16
- Volume
- 297
- Issue
- 5584
- Pages
- 1170-1173
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1653566113
- Cited by
- 281
- References
- 21
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- closed
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