Cited by 553Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceDNA Repair Mechanisms

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Aging and Genome Maintenance: Lessons from the Mouse?

Hasty, Paul, Campisi, Judith, Hoeijmakers, Jan, van Steeg, Harry, Vijg, Jan·2003·Science

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Abstract

Recent progress in the science of aging is driven largely by the use of model systems, ranging from yeast and nematodes to mice. These models have revealed conservation in genetic pathways that balance energy production and its damaging by-products with pathways that preserve somatic maintenance. Maintaining genome integrity has emerged as a major factor in longevity and cell viability. Here we discuss the use of mouse models with defects in genome maintenance for understanding the molecular basis of aging in humans.

Integrity signals

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Crossref · 10.1126/science.1079161

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Authors: Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H., & Vijg, J.
Affiliations: Department of Molecular Medicine,
Buck Institute for Research on Aging (US)
Erasmus University Rotterdam (NL)
National Institute of Public Health and the Environment, Post Office Box 1, 3720 BA Bilthoven, Netherlands.
The University of Texas at San Antonio Health Science Center (US)
Corresponding author: Hasty, Paul
Vijg, Jan
ORCID: Hasty, Paul
Campisi, Judith
Hoeijmakers, Jan
Vijg, Jan
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2003-02-28
Volume: 299
Issue: 5611
Pages: 1355-1359
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1079161
OpenAlex: W2133469432
Cited by: 553
References: 124
Citations by year: 2026: 5 · 2025: 2 · 2024: 7 · 2023: 12 · 2022: 12 · 2021: 10 · 2020: 14 · 2019: 15 · 2018: 13 · 2017: 8 · 2016: 25 · 2015: 18 · 2014: 27 · 2013: 29 · 2012: 32
FWCI: 3.36
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
Funders: National Institute on Aging (AG 17242, P01AG017242)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords: aging, genome maintenance, genome stability, mouse model, longevity, somatic maintenance, energy metabolism, DNA damage, model organisms, human aging
MeSH terms: Werner Syndrome Helicase, Aging, Animals, DNA Damage, DNA Repair, DNA Helicases, Exodeoxyribonucleases, Humans, Longevity, Mutation, Syndrome, Transcription, Genetic, Genome, Human, Telomere, Genome, Cellular Senescence, Apoptosis, Reactive Oxygen Species, Aging, Premature, Mice, RecQ Helicases

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Aging and Genome Maintenance: Lessons from the Mouse?

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