The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Role of EDEM in the Release of Misfolded Glycoproteins from the Calnexin Cycle
Abstract
The mechanisms that determine how folding attempts are interrupted to target folding-incompetent proteins for endoplasmic reticulum–associated degradation (ERAD) are poorly defined. Here the α-mannosidase I–like protein EDEM was shown to extract misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. EDEM overexpression resulted in faster release of folding-incompetent proteins from the calnexin cycle and earlier onset of degradation, whereas EDEM down-regulation prolonged folding attempts and delayed ERAD. Up-regulation of EDEM during ER stress may promote cell recovery by clearing the calnexin cycle and by accelerating ERAD of terminally misfolded polypeptides.
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Hammond, C., Braakman, I., & Helenius, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.3.913 · Cited by 841
Dissecting glycoprotein quality control in the secretory pathway
Cabral, C. M., Liu, Y., & Sifers, R. N. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01942-9 · Cited by 230
Cited by
Roles of N-Linked Glycans in the Endoplasmic Reticulum
Helenius, A., & Aebi, M. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073752 · Cited by 2,037
One step at a time: endoplasmic reticulum-associated degradation
Vembar, S. S., & Brodsky, J. L. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2546 · Cited by 1,299
Yoshida, H. (2007) · The FEBS Journal · doi:10.1111/j.1742-4658.2007.05639.x · Cited by 1,086
Protein quality control in the early secretory pathway
Anelli, T., & Sitia, R. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601974 · Cited by 623
Hetz, C., Thielen, P., Matus, S., Nassif, M., Court, F., Kiffin, R., Martinez, G., Cuervo, A. M., Brown, R. H., & Glimcher, L. H. (2009) · Genes & Development · doi:10.1101/gad.1830709 · Cited by 530
Metadata
- Authors
- Molinari, M., Calanca, V., Galli, C., Lucca, P., & Paganetti, P.
- Venue
- Science
- Published
- 2003-02-28
- Volume
- 299
- Issue
- 5611
- Pages
- 1397-1400
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1964706050
- Cited by
- 470
- References
- 2
- FWCI
- 15.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Molinari, M., Calanca, V., Galli, C., Lucca, P., & Paganetti, P. (2003). Role of EDEM in the Release of Misfolded Glycoproteins from the Calnexin Cycle. Science. https://doi.org/10.1126/science.1079474
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