Protein quality control in the early secretory pathway
Open accessAbstract
Eukaryotic cells are able to discriminate between native and non-native polypeptides, selectively transporting the former to their final destinations. Secretory proteins are scrutinized at the endoplasmic reticulum (ER)-Golgi interface. Recent findings reveal novel features of the underlying molecular mechanisms, with several chaperone networks cooperating in assisting the maturation of complex proteins and being selectively induced to match changing synthetic demands. 'Public' and 'private' chaperones, some of which enriched in specializes subregions, operate for most or selected substrates, respectively. Moreover, sequential checkpoints are distributed along the early secretory pathway, allowing efficiency and fidelity in protein secretion.
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The proteasome complex participates in the maintenance of protein homeostasis, and its dysfunction contributes to the accumulation of protein aggregates.
“a proteolytic machinery that participates in the maintenance of protein homeostasis and its dysfunction contributes to the accumulation of protein aggregates [51]”
UPR is an adaptive pathway to restore protein folding equilibrium.
“an adaptive pathway to restore protein folding equilibrium [51]”
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- Hendershot L, Sitia R (2005) Immunoglobulin assembly and secre- tion. In Molecular Biology of B Cells, Honjo T, Alt FW, Neuberger MS (eds), pp 261-273. Amsterdam, NL: Elsevier Acad Press
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- Authors
- Anelli, T., & Sitia, R.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- Corresponding author
- Sitia, Roberto
- Venue
- The EMBO Journal
- Published
- 2008-01-23
- Volume
- 27
- Issue
- 2
- Pages
- 315-327
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC2234347
- OpenAlex
- W2094372926
- Cited by
- 623
- References
- 180
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 23 · 2023: 27 · 2022: 31 · 2021: 38 · 2020: 33 · 2019: 36 · 2018: 25 · 2017: 35 · 2016: 32 · 2015: 30 · 2014: 33 · 2013: 44 · 2012: 34
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- protein quality control, early secretory pathway, ER-Golgi interface, molecular chaperones, protein maturation, protein secretion, endoplasmic reticulum
- MeSH terms
- Endoplasmic Reticulum, Models, Biological, Proteins, Signal Transduction, Protein Folding
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