Cited by 623Heat shock proteins researchEndoplasmic Reticulum Stress and DiseaseCellular transport and secretion

Protein quality control in the early secretory pathway

Open access
Anelli, Tiziana, Sitia, Roberto·2008·The EMBO Journal

Abstract

Eukaryotic cells are able to discriminate between native and non-native polypeptides, selectively transporting the former to their final destinations. Secretory proteins are scrutinized at the endoplasmic reticulum (ER)-Golgi interface. Recent findings reveal novel features of the underlying molecular mechanisms, with several chaperone networks cooperating in assisting the maturation of complex proteins and being selectively induced to match changing synthetic demands. 'Public' and 'private' chaperones, some of which enriched in specializes subregions, operate for most or selected substrates, respectively. Moreover, sequential checkpoints are distributed along the early secretory pathway, allowing efficiency and fidelity in protein secretion.

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Crossref · 10.1038/sj.emboj.7601974

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  1. Hendershot L, Sitia R (2005) Immunoglobulin assembly and secre- tion. In Molecular Biology of B Cells, Honjo T, Alt FW, Neuberger MS (eds), pp 261-273. Amsterdam, NL: Elsevier Acad Press

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Authors
Anelli, T., & Sitia, R.
Affiliations
Vita-Salute San Raffaele University (IT)
Corresponding author
Sitia, Roberto
Venue
The EMBO Journal
Published
2008-01-23
Volume
27
Issue
2
Pages
315-327
ISSN
  • 0261-4189 (ISSN-L)
  • 1460-2075
OpenAlex
W2094372926
Cited by
623
References
180
Citations by year
2026: 14 · 2025: 18 · 2024: 23 · 2023: 27 · 2022: 31 · 2021: 38 · 2020: 33 · 2019: 36 · 2018: 25 · 2017: 35 · 2016: 32 · 2015: 30 · 2014: 33 · 2013: 44 · 2012: 34
FWCI
4.35
Type
journal article
Language
en
Open access
Locations
  • The EMBO Journal (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
Funders
Associazione Italiana per la Ricerca sul Cancro
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords
protein quality control, early secretory pathway, ER-Golgi interface, molecular chaperones, protein maturation, protein secretion, endoplasmic reticulum
MeSH terms
Endoplasmic Reticulum, Models, Biological, Proteins, Signal Transduction, Protein Folding

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