The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
A war on obesity, not the obese.
Abstract
In their efforts to lose weight, obese individuals may be fighting a powerful set of evolutionary forces honed in an environment drastically different from that of today.
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In the citing paper
“Obese individuals on average earn less money than their no-better-qualified lean counterparts and are promoted less readily (65,66).”
From Leptin at 14 y of age: an ongoing story (2009) · cites this paper as [66]
Citations
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Self-citationTuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Self-citationGuns, Germs, and Steel: The Fates of Human Societies.
Hardin, G., & Diamond, J. M. (1997) · Population and Development Review · doi:10.2307/2137390 · Cited by 4,983
Sick individuals and sick populations
Rose, G. (2001) · International Journal of Epidemiology · doi:10.1093/ije/30.3.427 · Cited by 3,736
Body-Mass Index and Mortality in a Prospective Cohort of U.S. Adults
Calle, E. E., Thun, M. J., Petrelli, J. M., Rodriguez, C., & Heath, C. W. (1999) · New England Journal of Medicine · doi:10.1056/nejm199910073411501 · Cited by 3,643
Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?
Neel, J. V. (1962) · Europe PMC (PubMed Central) · Cited by 3,172
Congenital leptin deficiency is associated with severe early-onset obesity in humans
Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936
Research works printed but not linked: 5
- Allison D., et al., Int. J. Obes. 20, 501 (1996).
- Wadden T. A., et al., J. Clin. Endocrinol. Metab. 83, 214 (1998).
- Kumanyika S., Ethn. Dis. 12, 316 (2002).
- Zimmet P., et al., Diabetes Res. 1, 13 (1984).
- Neel J. V., Am. J. Hum. Genet. 14, 353 (1962).
Cited by
Sorted by citations
Obesity and the Environment: Where Do We Go from Here?
Hill, J. O., Wyatt, H. R., Reed, G. W., & Peters, J. C. (2003) · Science · doi:10.1126/science.1079857 · Cited by 2,180
Ogden, C. L., Yanovski, S. Z., Carroll, M. D., & Flegal, K. M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.052 · Cited by 1,561
Anti-obesity drug discovery: advances and challenges
Müller, T. D., Blüher, M., Tschöp, M. H., & DiMarchi, R. D. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00337-8 · Cited by 1,021
Regulation of Fasted Blood Glucose by Resistin
Banerjee, R. R., Rangwala, S. M., Shapiro, J. S., Rich, A. S., Rhoades, B., Qi, Y., Wang, J., Rajala, M. W., Pocai, A., Scherer, P. E., et al. (2004) · Science · doi:10.1126/science.1092341 · Cited by 741
Leptin and the endocrine control of energy balance
Friedman, J. M. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0095-y · Cited by 661
Self-citation
Metadata
- Authors
- Friedman, J. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Friedman, Jeffrey M.
- ORCID
- Friedman, Jeffrey M.
- Venue
- Science
- Published
- 2003-02-07
- Volume
- 299
- Issue
- 5608
- Pages
- 856-858
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2019056933
- Cited by
- 375
- References
- 36
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 21 · 2015: 17 · 2014: 22 · 2013: 12 · 2012: 19
- FWCI
- 104.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK-41096, R01DK041096)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity and Health Practices
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- obesity, weight loss, adaptive evolution, human evolution, modern environments
- MeSH terms
- Adipose Tissue, Body Weight, Energy Intake, Diet, Energy Metabolism, Feeding Behavior, Female, Genes, Homeostasis, Humans, Hunger, Life Style, Male, Obesity, Public Health, Selection, Genetic, United States, Weight Loss, Body Mass Index, Incidence, Leptin
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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