CoChat
Sign Up
Cited by 1,641Developmental Biology and Gene RegulationGenomics and Phylogenetic StudiesMarine Invertebrate Physiology and Ecology

The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.

The Draft Genome of Ciona intestinalis : Insights into Chordate and Vertebrate Origins

Open access
Dehal, Paramvir, Satou, Yutaka, Campbell, Robert K., Chapman, Jarrod, Degnan, Bernard, De Tomaso, Anthony, Davidson, Brad, Di Gregorio, Anna, Gelpke, Maarten, Goodstein, David M., Harafuji, Naoe, Hastings, Kenneth E. M., Ho, Isaac, Hotta, Kohji, Huang, Wayne, Kawashima, Takeshi, Lemaire, Patrick, Martinez, Diego, Meinertzhagen, Ian A., Necula, Simona, Nonaka, Masaru, Putnam, Nik, Rash, Sam, Saiga, Hidetoshi, Satake, Masanobu, Terry, Astrid, Yamada, Lixy, Wang, Hong-Gang, Awazu, Satoko, Azumi, Kaoru, Boore, Jeffrey, Branno, Margherita, Chin-bow, Stephen, DeSantis, Rosaria, Doyle, Sharon, Francino, Pilar, Keys, David N., Haga, Shinobu, Hayashi, Hiroko, Hino, Kyosuke, Imai, Kaoru S., Inaba, Kazuo, Kano, Shungo, Kobayashi, Kenji, Kobayashi, Mari, Lee, Byung-In, Makabe, Kazuhiro W., Manohar, Chitra, Matassi, Giorgio, Medina, Monica, Mochizuki, Yasuaki, Mount, Steve, Morishita, Tomomi, Miura, Sachiko, Nakayama, Akie, Nishizaka, Satoko, Nomoto, Hisayo, Ohta, Fumiko, Oishi, Kazuko, Rigoutsos, Isidore, Sano, Masako, Sasaki, Akane, Sasakura, Yasunori, Shoguchi, Eiichi, Shin-i, Tadasu, Spagnuolo, Antoinetta, Stainier, Didier, Suzuki, Miho M., Tassy, Olivier, Takatori, Naohito, Tokuoka, Miki, Yagi, Kasumi, Yoshizaki, Fumiko, Wada, Shuichi, Zhang, Cindy, Hyatt, P. Douglas, Larimer, Frank, Detter, Chris, Doggett, Norman, Glavina, Tijana, Hawkins, Trevor, Richardson, Paul, Lucas, Susan, Kohara, Yuji, Levine, Michael, Satoh, Nori, Rokhsar, Daniel S.·2002·Science
DOI 10.1126/science.1080049
Open this paper in CoChat — free accountOpen PDF

Abstract

The first chordates appear in the fossil record at the time of the Cambrian explosion, nearly 550 million years ago. The modern ascidian tadpole represents a plausible approximation to these ancestral chordates. To illuminate the origins of chordate and vertebrates, we generated a draft of the protein-coding portion of the genome of the most studied ascidian, Ciona intestinalis . The Ciona genome contains ∼16,000 protein-coding genes, similar to the number in other invertebrates, but only half that found in vertebrates. Vertebrate gene families are typically found in simplified form in Ciona , suggesting that ascidians contain the basic ancestral complement of genes involved in cell signaling and development. The ascidian genome has also acquired a number of lineage-specific innovations, including a group of genes engaged in cellulose metabolism that are related to those in bacteria and fungi.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/science.1080049

Cites

81 of 81 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 10

  1. Kowalevsky A., Mem. Acad. St. Petersbourg Ser. 7 10, 1 (1866).
  2. Nishida H., Int. Rev. Cytol. 176, 24 (1997).
  3. Conklin E. G., J. Acad. Nat. Sci. (Philadelphia) 13, 1 (1905).
  4. 10.1016/S0022-2836(05)80360-2 · DOI · Paper page
  5. C. K. Weichert Elements of Chordate Anatomy (McGraw-Hill New York 1953).
  6. P. Joost A. Methner Genome Biol. in press.
  7. Ulrich H. D., Curr. Top. Microbiol. Immunol. 268, 137 (2002).
  8. Tomarev S. I., Int. J. Dev. Biol. 41, 835 (1997).
  9. Krishnan G., Indian J. Exp. Biol. 13, 172 (1975).
  10. Zuo J., et al., Plant Cell 12, 1137 (2000).

Cited by

Sorted by citations

See all 1,641

Related

See all

Metadata

Authors
Dehal, P., Satou, Y., Campbell, R. K., Chapman, J., Degnan, B., De Tomaso, A., Davidson, B., Di Gregorio, A., Gelpke, M., Goodstein, D. M., Harafuji, N., Hastings, K. E. M., Ho, I., Hotta, K., Huang, W., Kawashima, T., Lemaire, P., Martinez, D., Meinertzhagen, I. A., Necula, S., Nonaka, M., Putnam, N., Rash, S., Saiga, H., Satake, M., Terry, A., Yamada, L., Wang, H.-G., Awazu, S., Azumi, K., Boore, J., Branno, M., Chin-bow, S., DeSantis, R., Doyle, S., Francino, P., Keys, D. N., Haga, S., Hayashi, H., Hino, K., Imai, K. S., Inaba, K., Kano, S., Kobayashi, K., Kobayashi, M., Lee, B.-I., Makabe, K. W., Manohar, C., Matassi, G., Medina, M., Mochizuki, Y., Mount, S., Morishita, T., Miura, S., Nakayama, A., Nishizaka, S., Nomoto, H., Ohta, F., Oishi, K., Rigoutsos, I., Sano, M., Sasaki, A., Sasakura, Y., Shoguchi, E., Shin-i, T., Spagnuolo, A., Stainier, D., Suzuki, M. M., Tassy, O., Takatori, N., Tokuoka, M., Yagi, K., Yoshizaki, F., Wada, S., Zhang, C., Hyatt, P. D., Larimer, F., Detter, C., Doggett, N., Glavina, T., Hawkins, T., Richardson, P., Lucas, S., Kohara, Y., Levine, M., Satoh, N., & Rokhsar, D. S.
Affiliations
  • Joint Genome Institute (US)
  • Kyoto University (JP)
  • Marine Biological Laboratory (US)
  • The University of Queensland (AU)
  • Department of Pathology, Stanford University School of Medicine, Stanford, CA 93950, USA.
  • University of California, Berkeley (US)
  • Department of Molecular and Cellular Biology, Division of Genetics, 401 Barker Hall, University of California, Berkeley, CA 94720, USA.
  • McGill University (CA)
  • National Institute of Genetics (JP)
  • Institut de Biologie du Développement Marseille (FR)
  • Dalhousie University (CA)
  • The University of Tokyo (JP)
  • U.S. Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.
  • Tokyo Metropolitan University (JP)
  • Tohoku University (JP)
  • Moffitt Cancer Center (US)
  • Hokkaido University (JP)
  • Stazione Zoologica Anton Dohrn (IT)
  • IBM (United States) (US)
  • University of Maryland, College Park, MD 20742, USA.
  • National Institute of Genetics, Mishima 411-8540, Japan.
  • Stazione Zoologica “Anton Dohrn,” Villa Comunale, 80121 Napoli, Italy.
  • University of California, San Francisco (US)
  • Wellcome Centre for Cell Biology (GB)
  • Oak Ridge National Laboratory, Post Office Box 2008, Oak Ridge, TN 37831, USA.
  • Oak Ridge National Laboratory (US)
  • Los Alamos National Laboratory (US)
Corresponding author
  • Dehal, Paramvir
  • Satou, Yutaka
  • Kohara, Yuji
  • Levine, Michael
  • Satoh, Nori
  • Rokhsar, Daniel S.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2002-12-13
Volume
298
Issue
5601
Pages
2157-2167
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1080049
OpenAlex
W2170258388
Cited by
1,641
References
81
Citations by year
2026: 20 · 2025: 15 · 2024: 41 · 2023: 26 · 2022: 27 · 2021: 36 · 2020: 41 · 2019: 29 · 2018: 51 · 2017: 49 · 2016: 43 · 2015: 46 · 2014: 62 · 2013: 62 · 2012: 74
FWCI
49.61
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • HAL AMU (submittedVersion, cc-by-nc)
  • Tokyo Tech Research Repository (Tokyo Institute of Technology) (submittedVersion)
Funders
  • National Institutes of Health (5p01hd037105-20)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD37105)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
Keywords
Ciona intestinalis, chordate evolution, vertebrate origin, gene family evolution, protein-coding genes, gene loss, developmental genes, Cambrian explosion
MeSH terms
Alleles, Animals, Base Sequence, Cellulose, Central Nervous System, Ciona intestinalis, Endocrine System, Genes, Genes, Homeobox, Multigene Family, Heart, Immunity, Molecular Sequence Data, Muscle Proteins, Phylogeny, Polymorphism, Genetic, Proteins, Sequence Homology, Nucleic Acid, Species Specificity, Thyroid Gland, Urochordata, Vertebrates, Genome, Apoptosis, Sequence Analysis, DNA, Gene Dosage, Computational Biology, Gene Duplication, Organizers, Embryonic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review