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Myc-Induced T Cell Leukemia in Transgenic Zebrafish
Abstract
The zebrafish is an attractive model organism for studying cancer development because of its genetic accessibility. Here we describe the induction of clonally derived T cell acute lymphoblastic leukemia in transgenic zebrafish expressing mouse c- myc under control of the zebrafish Rag2 promoter. Visualization of leukemic cells expressing a chimeric transgene encoding Myc fused to green fluorescent protein (GFP) revealed that leukemias arose in the thymus, spread locally into gill arches and retro-orbital soft tissue, and then disseminated into skeletal muscle and abdominal organs. Leukemic cells homed back to the thymus in irradiated fish transplanted with GFP-labeled leukemic lymphoblasts. This transgenic model provides a platform for drug screens and for genetic screens aimed at identifying mutations that suppress or enhance c- myc – induced carcinogenesis.
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Citations
Cited by
Pui, C.-H., Robison, L. L., & Look, A. T. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60457-2 · Cited by 1,564
Self-citationTransplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants
Traver, D., Paw, B. H., Poss, K. D., Penberthy, W. T., Lin, S., & Zon, L. I. (2003) · Nature Immunology · doi:10.1038/ni1007 · Cited by 800
Self-citationThe Varied Roles of Notch in Cancer
Aster, J. C., Pear, W. S., & Blacklow, S. C. (2017) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100127 · Cited by 710
Self-citationThe ‘definitive’ (and ‘primitive’) guide to zebrafish hematopoiesis
Davidson, A. J., & Zon, L. I. (2004) · Oncogene · doi:10.1038/sj.onc.1207943 · Cited by 419
Self-citationMany Ribosomal Protein Genes Are Cancer Genes in Zebrafish
Amsterdam, A., Sadler, K. C., Lai, K., Farrington, S., Bronson, R. T., Lees, J. A., & Hopkins, N. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020139 · Cited by 417
Metadata
- Authors
- Langenau, D. M., Traver, D., Ferrando, A. A., Kutok, J. L., Aster, J. C., Kanki, J. P., Lin, S., Prochownik, E., Trede, N. S., Zon, L. I., & Look, A. T.
- Venue
- Science
- Published
- 2003-02-07
- Volume
- 299
- Issue
- 5608
- Pages
- 887-890
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2121676856
- Cited by
- 541
- References
- 0
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Langenau, D. M., Traver, D., Ferrando, A. A., Kutok, J. L., Aster, J. C., Kanki, J. P., Lin, S., Prochownik, E., Trede, N. S., Zon, L. I., & Look, A. T. (2003). Myc-Induced T Cell Leukemia in Transgenic Zebrafish. Science. https://doi.org/10.1126/science.1080280
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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