The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The Birth of an Alternatively Spliced Exon: 3' Splice-Site Selection in Alu Exons
Abstract
Alu repetitive elements can be inserted into mature messenger RNAs via a splicing-mediated process termed exonization. To understand the molecular basis and the regulation of the process of turning intronic Alu s into new exons, we compiled and analyzed a data set of human exonized Alu s. We revealed a mechanism that governs 3′ splice-site selection in these exons during alternative splicing. On the basis of these findings, we identified mutations that activated the exonization of a silent intronic Alu .
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Cites
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Alu -Containing Exons are Alternatively Spliced
Sorek, R., Ast, G., & Graur, D. (2002) · Genome Research · doi:10.1101/gr.229302 · Cited by 505
Self-citationTransposable elements are found in a large number of human protein-coding genes
Nekrutenko, A., & Li, W.-H. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02445-3 · Cited by 430
Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins
Caras, I. W., Davitz, M. A., Rhee, L., Weddell, G., Martin, D. W., & Nussenzweig, V. (1987) · Nature · doi:10.1038/325545a0 · Cited by 351
On "genomenclature": a comprehensive (and respectful) taxonomy for pseudogenes and other "junk DNA".
Brosius, J., & Gould, S. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10706 · Cited by 307
Reconstruction and analysis of human alu genes
Jurka, J., & Milosavljevic, A. (1991) · Journal of Molecular Evolution · doi:10.1007/bf02515383 · Cited by 289
Alu sequences in the coding regions of mRNA: a source of protein variability
Makałowski, W., Mitchell, G. A., & Labuda, D. (1994) · Trends in Genetics · doi:10.1016/0168-9525(94)90254-2 · Cited by 283
Genomic scrap yard: how genomes utilize all that junk
Makałowski, W. (2000) · Gene · doi:10.1016/s0378-1119(00)00436-4 · Cited by 196
Alu: Structure, Origin, Evolution, Significance, and Function of One-Tenth of Human DNA
Schmid, C. W. (1996) · Progress in Nucleic Acid Research and Molecular Biology · doi:10.1016/s0079-6603(08)60148-8 · Cited by 192
Lai, F., Chen, C.-X., Carter, K. C., & Nishikura, K. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.5.2413 · Cited by 189
Cited by
Function of alternative splicing
Stamm, S., Ben-Ari, S., Rafalska, I., Tang, Y., Zhang, Z., Toiber, D., Thanaraj, T. A., & Soreq, H. (2005) · Gene · doi:10.1016/j.gene.2004.10.022 · Cited by 1,377
Alternative splicing and evolution: diversification, exon definition and function
Keren, H., Lev-Maor, G., & Ast, G. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2776 · Cited by 1,082
Self-citationThe Evolutionary Landscape of Alternative Splicing in Vertebrate Species
Barbosa-Morais, N. L., Irimia, M., Pan, Q., Xiong, H. Y., Gueroussov, S., Lee, L. J., Slobodeniuc, V., Kutter, C., Watt, S., Çolak, R., et al. (2012) · Science · doi:10.1126/science.1230612 · Cited by 1,063
The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics
Stein, L. D., Bao, Z., Blasiar, D., Blumenthal, T., Brent, M. R., Chen, N., Chinwalla, A., Clarke, L., Clee, C., Coghlan, A., et al. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000045 · Cited by 940
Function of alternative splicing
Kelemen, O., Convertini, P., Zhang, Z., Wen, Y., Shen, M., Falaleeva, M., & Stamm, S. (2013) · Gene · doi:10.1016/j.gene.2012.07.083 · Cited by 743
Metadata
- Authors
- Lev-Maor, G., Sorek, R., Shomron, N., & Ast, G.
- Venue
- Science
- Published
- 2003-05-23
- Volume
- 300
- Issue
- 5623
- Pages
- 1288-1291
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965074434
- Cited by
- 434
- References
- 20
- FWCI
- 11.47
- Type
- journal article
- Language
- en
- Open access
- closed
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