The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help
Open accessAbstract
The CD8 + cytotoxic T cell response to pathogens is thought to be CD4 + helper T cell independent because infectious agents provide their own inflammatory signals. Mice that lack CD4 + T cells mount a primary CD8 response to Listeria monocytogenes equal to that of wild-type mice and rapidly clear the infection. However, protective memory to a challenge is gradually lost in the former animals. Memory CD8 + T cells from normal mice can respond rapidly, but memory CD8 + T cells that are generated without CD4 help are defective in their ability to respond to secondary encounters with antigen. The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development.
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“Without this additional signal, the activated ‘helpless’ CTL function as primary effector T cells but with a short lifespan69 or die via activation-induced cell death following subsequent exposure to antigen70,71.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [70]
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“The latter cell death is mediated by expression of the death ligand TRAIL, which triggers apoptosis in the helpless CTL as well as other activated T cells70,72.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [70]
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Metadata
- Authors
- Sun, J. C., & Bevan, M. J.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Bevan, Michael J.
- Venue
- Science
- Published
- 2003-04-11
- Volume
- 300
- Issue
- 5617
- Pages
- 339-342
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2778341
- OpenAlex
- W2076534074
- Cited by
- 1,213
- References
- 26
- Citations by year
- 2026: 4 · 2025: 16 · 2024: 18 · 2023: 18 · 2022: 19 · 2021: 31 · 2020: 28 · 2019: 18 · 2018: 24 · 2017: 21 · 2016: 28 · 2015: 32 · 2014: 51 · 2013: 46 · 2012: 58
- FWCI
- 40.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Allergy and Infectious Diseases (R01AI019335, AI-19335)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- CD8+ T cell memory, CD4+ T cell help, Listeria monocytogenes, acute infection, CD4-deficient mice, cytotoxic T lymphocytes, protective immunity
- MeSH terms
- Animals, Cytotoxicity, Immunologic, Genes, MHC Class II, T-Lymphocytes, Helper-Inducer, Immunization, Immunologic Memory, Interferon-gamma, Listeriosis, Listeria monocytogenes, Mice, Inbred C57BL, Ovalbumin, T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes, Adoptive Transfer, Mice
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