The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help
Open accessAbstract
The CD8 + cytotoxic T cell response to pathogens is thought to be CD4 + helper T cell independent because infectious agents provide their own inflammatory signals. Mice that lack CD4 + T cells mount a primary CD8 response to Listeria monocytogenes equal to that of wild-type mice and rapidly clear the infection. However, protective memory to a challenge is gradually lost in the former animals. Memory CD8 + T cells from normal mice can respond rapidly, but memory CD8 + T cells that are generated without CD4 help are defective in their ability to respond to secondary encounters with antigen. The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development.
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“Without this additional signal, the activated ‘helpless’ CTL function as primary effector T cells but with a short lifespan69 or die via activation-induced cell death following subsequent exposure to antigen70,71.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [70]
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“The latter cell death is mediated by expression of the death ligand TRAIL, which triggers apoptosis in the helpless CTL as well as other activated T cells70,72.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [70]
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Cites
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T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
Schoenberger, S. P., Toes, R. E. M., van der Voort, E. I. H., Offringa, R., & Melief, C. J. M. (1998) · Nature · doi:10.1038/31002 · Cited by 2,615
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
Ridge, J. P., Rosa, F. D., & Matzinger, P. (1998) · Nature · doi:10.1038/30989 · Cited by 2,360
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
Bennett, S. R. M., Carbone, F., Karamalis, F., Flavell, R. A., Miller, J. F. A. P., & Heath, W. R. (1998) · Nature · doi:10.1038/30996 · Cited by 2,091
Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function
Zajac, A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J. D., Suresh, M., Altman, J. D., & Ahmed, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2205 · Cited by 1,978
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
Janssen, E. M., Lemmens, E. E., Wolfe, T., Christen, U., von Herrath, M. G., & Schoenberger, S. P. (2003) · Nature · doi:10.1038/nature01441 · Cited by 1,635
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection
Matloubian, M., Concepcion, R. J., & Ahmed, R. (1994) · Journal of Virology · doi:10.1128/jvi.68.12.8056-8063.1994 · Cited by 1,162
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The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses
Kalams, S. A., & Walker, B. D. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2199 · Cited by 660
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Toll-like receptor control of the adaptive immune responses
Iwasaki, A., & Medzhitov, R. M. (2004) · Nature Immunology · doi:10.1038/ni1112 · Cited by 4,166
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067
Cancer immunotherapy via dendritic cells
Palucka, K., & Banchereau, J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3258 · Cited by 2,109
CD4+ T cell help in cancer immunology and immunotherapy
Borst, J., Ahrends, T., Bąbała, N., Melief, C. J. M., & Kastenmüller, W. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0044-0 · Cited by 1,585
Krammer, F., Smith, G. J. D., Fouchier, R. A. M., Peiris, M. J. S., Kedzierska, K., Doherty, P. C., Palese, P., Shaw, M. L., Treanor, J. J., Webster, R. G., et al. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0002-y · Cited by 1,591
Metadata
- Authors
- Sun, J. C., & Bevan, M. J.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Bevan, Michael J.
- Venue
- Science
- Published
- 2003-04-11
- Volume
- 300
- Issue
- 5617
- Pages
- 339-342
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2778341
- OpenAlex
- W2076534074
- Cited by
- 1,213
- References
- 26
- Citations by year
- 2026: 4 · 2025: 16 · 2024: 18 · 2023: 18 · 2022: 19 · 2021: 31 · 2020: 28 · 2019: 18 · 2018: 24 · 2017: 21 · 2016: 28 · 2015: 32 · 2014: 51 · 2013: 46 · 2012: 58
- FWCI
- 40.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Allergy and Infectious Diseases (R01AI019335, AI-19335)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- CD8+ T cell memory, CD4+ T cell help, Listeria monocytogenes, acute infection, CD4-deficient mice, cytotoxic T lymphocytes, protective immunity
- MeSH terms
- Animals, Cytotoxicity, Immunologic, Genes, MHC Class II, T-Lymphocytes, Helper-Inducer, Immunization, Immunologic Memory, Interferon-gamma, Listeriosis, Listeria monocytogenes, Mice, Inbred C57BL, Ovalbumin, T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes, Adoptive Transfer, Mice
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