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Cited by 660T-cell and B-cell ImmunologyHIV Research and TreatmentImmunotherapy and Immune Responses

The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses

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Kalams, Spyros A., Walker, Bruce D.·1998·The Journal of Experimental Medicine
DOI 10.1084/jem.188.12.2199PMC PMC2212425
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Abstract

For many viral infections, resolution of illness is associated with long-term host control of viremia rather than viral eradication. An example is EBV infection, and the fact that host immune suppression is associated with EBV-induced disease suggests that it is the immune system that is holding the

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  • The presence of tumor-infiltrating CD8+ T cells and the production of Th1 cytokines within tumors are correlated with favorable prognoses in overall survival and disease-free survival across various malignancies.

    “The presence of tumor-infiltrating CD8+ T cells and the production of Th1 cytokines within tumors have been correlated with favorable prognoses in terms of overall survival and disease-free survival across various malignancies [11,12,13,14].”

    From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [12]

    The paper’s main text (page unavailable) discusses CD8+ T cells and IFN-γ in viral infections, including correlations with HIV viral burden, not tumor-infiltrating cells or cancer survival. Searches for tumor infiltration, Th1 cytokines, prognosis, and overall or disease-free survival found no passage addressing the attributed claim. (LLM, conf=0.77)

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Cites

  • Phenotypic Analysis of Antigen-Specific T Lymphocytes

    Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544 · cited 1× · see citing works

    “(20) now provide insights into how CD4 deficiency may impair CTL responses, and like other recent advances in understanding of CTLs these data have been facilitated by the direct visualization of CTL using peptide–MHC tetramers (29).”
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Authors
Kalams, S. A., & Walker, B. D.
Affiliations
Harvard University (US)
ORCID
Venue
The Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
1998-12-21
Volume
188
Issue
12
Pages
2199-2204
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.188.12.2199
PMC
PMC2212425
OpenAlex
W2031477951
Cited by
660
References
1
Citations by year
2026: 1 · 2025: 5 · 2024: 13 · 2023: 3 · 2022: 9 · 2021: 10 · 2020: 11 · 2019: 6 · 2018: 10 · 2017: 6 · 2016: 5 · 2015: 12 · 2014: 13 · 2013: 10 · 2012: 17
FWCI
5.77
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • The Journal of Experimental Medicine (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
CD4+ T cells, cytotoxic T lymphocytes, cytotoxic T lymphocyte response, Epstein-Barr virus infection, immunosuppression
MeSH terms
Animals, Arenaviridae Infections, T-Lymphocytes, Helper-Inducer, Humans, Lymphocyte Cooperation, Lymphocytic choriomeningitis virus, T-Lymphocytes, Cytotoxic, Virus Diseases, HIV Infections, Clonal Anergy

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