The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Immunological Synapse Balances T Cell Receptor Signaling and Degradation
Abstract
The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.
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Cites
TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
Štefanová, I., Hemmer, B., Vergelli, M., Martin, R., Biddison, W. E., & Germain, R. N. (2003) · Nature Immunology · doi:10.1038/ni895 · Cited by 465
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The Cbl interactome and its functions
Schmidt, M. H. H., & Dikic, I. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1762 · Cited by 395
Offner, S., Hofmeister, R., Romaniuk, A., Kufer, P., & Baeuerle, P. A. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2005.03.007 · Cited by 365
Rules for Modeling Signal-Transduction Systems
Hlavacek, W. S., Faeder, J. R., Blinov, M. L., Posner, R. G., Hucka, M., & Fontana, W. (2006) · Science's STKE · doi:10.1126/stke.3442006re6 · Cited by 350
Tuning immune responses: diversity and adaptation of the immunological synapse
Friedl, P., den Boer, A. T., & Gunzer, M. (2005) · Nature Reviews Immunology · doi:10.1038/nri1647 · Cited by 276
Immunological synapse and microclusters: the site for recognition and activation of T cells
Saito, T., & Yokosuka, T. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.03.014 · Cited by 124
Metadata
- Authors
- Lee, K.-H., Dinner, A. R., Tu, C., Campi, G., Raychaudhuri, S., Varma, R., Sims, T. N., Burack, W. R., Wu, H., Wang, J., Kanagawa, O., Markiewicz, M., Allen, P. M., Dustin, M. L., Chakraborty, A. K., & Shaw, A. S.
- Venue
- Science
- Published
- 2003-11-14
- Volume
- 302
- Issue
- 5648
- Pages
- 1218-1222
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2107919289
- Cited by
- 545
- References
- 1
- FWCI
- 16.54
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
