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The Immunological Synapse Balances T Cell Receptor Signaling and Degradation
Abstract
The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.
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Cites
TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
Štefanová, I., Hemmer, B., Vergelli, M., Martin, R., Biddison, W. E., & Germain, R. N. (2003) · Nature Immunology · doi:10.1038/ni895 · Cited by 465
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Rules for Modeling Signal-Transduction Systems
Hlavacek, W. S., Faeder, J. R., Blinov, M. L., Posner, R. G., Hucka, M., & Fontana, W. (2006) · Science's STKE · doi:10.1126/stke.3442006re6 · Cited by 350
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Endogenous retroviral pathogenesis in lupus
Perl, A., Fernandez, D., Telarico, T., & Phillips, P. E. (2010) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32833c6297 · Cited by 75
Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies
Dupré, L., Boztug, K., & Pfajfer, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.665519 · Cited by 64
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Perl, A., Nagy, G., Koncz, A., Gergely, P., Fernandez, D., Doherty, E., Telarico, T., Bonilla, E., & Phillips, P. E. (2008) · Autoimmunity · doi:10.1080/08916930802024764 · Cited by 58
SNX17 Affects T Cell Activation by Regulating TCR and Integrin Recycling
Osborne, D. G., Piotrowski, J. T., Dick, C. J., Zhang, J.-S., & Billadeau, D. D. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402734 · Cited by 50
Metadata
- Authors
- Lee, K.-H., Dinner, A. R., Tu, C., Campi, G., Raychaudhuri, S., Varma, R., Sims, T. N., Burack, W. R., Wu, H., Wang, J., Kanagawa, O., Markiewicz, M., Allen, P. M., Dustin, M. L., Chakraborty, A. K., & Shaw, A. S.
- Venue
- Science
- Published
- 2003-11-14
- Volume
- 302
- Issue
- 5648
- Pages
- 1218-1222
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2107919289
- Cited by
- 545
- References
- 1
- FWCI
- 16.54
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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