The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Epidermal Viral Immunity Induced by CD8α + Dendritic Cells But Not by Langerhans Cells
Abstract
The classical paradigm for dendritic cell function derives from the study of Langerhans cells, which predominate within skin epidermis. After an encounter with foreign agents, Langerhans cells are thought to migrate to draining lymph nodes, where they initiate T cell priming. Contrary to this, we show here that infection of murine epidermis by herpes simplex virus did not result in the priming of virus-specific cytotoxic T lymphocytes by Langerhans cells. Rather, the priming response required a distinct CD8α + dendritic cell subset. Thus, the traditional view of Langerhans cells in epidermal immunity needs to be revisited to accommodate a requirement for other dendritic cells in this response.
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Cites
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Cited by
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Batf3 Deficiency Reveals a Critical Role for CD8α + Dendritic Cells in Cytotoxic T Cell Immunity
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Differential Antigen Processing by Dendritic Cell Subsets in Vivo
Dudziak, D., Kamphorst, A. O., Heidkamp, G. F., Buchholz, V. R., Trumpfheller, C., Yamazaki, S., Cheong, C., Liu, K., Lee, H.-W., Park, C. G., et al. (2007) · Science · doi:10.1126/science.1136080 · Cited by 1,455
Immunogenic and tolerogenic cell death
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Metadata
- Authors
- Allan, R. S., Smith, C. M., Belz, G. T., van Lint, A. L., Wakim, L. M., Heath, W. R., & Carbone, F. R.
- Venue
- Science
- Published
- 2003-09-26
- Volume
- 301
- Issue
- 5641
- Pages
- 1925-1928
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2067853799
- Cited by
- 567
- References
- 21
- FWCI
- 14.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Allan, R. S., Smith, C. M., Belz, G. T., van Lint, A. L., Wakim, L. M., Heath, W. R., & Carbone, F. R. (2003). Epidermal Viral Immunity Induced by CD8α + Dendritic Cells But Not by Langerhans Cells. Science. https://doi.org/10.1126/science.1087576
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
