The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
The Origins of Genome Complexity
Abstract
Complete genomic sequences from diverse phylogenetic lineages reveal notable increases in genome complexity from prokaryotes to multicellular eukaryotes. The changes include gradual increases in gene number, resulting from the retention of duplicate genes, and more abrupt increases in the abundance of spliceosomal introns and mobile genetic elements. We argue that many of these modifications emerged passively in response to the long-term population-size reductions that accompanied increases in organism size. According to this model, much of the restructuring of eukaryotic genomes was initiated by nonadaptive processes, and this in turn provided novel substrates for the secondary evolution of phenotypic complexity by natural selection. The enormous long-term effective population sizes of prokaryotes may impose a substantial barrier to the evolution of complex genomes and morphologies.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Given the extremely high costs of building and maintaining nervous systems [10–12], neutral evolutionary processes are arguably less prevalent during nervous system evolution than for example in genome evolution [13].”
From Origin and early evolution of neural circuits for the control of ciliary locomotion (2011) · cites this paper as [13]
Citations
Cites
Ohno, S. (1970) · doi:10.1007/978-3-642-86659-3 · Cited by 7,833
The Neutral Theory of Molecular Evolution
Kimura, M. (1979) · Scientific American · doi:10.1038/scientificamerican1179-98 · Cited by 7,687
The Neutral Theory of Molecular Evolution
Kimura, M. (1983) · Cambridge University Press eBooks · doi:10.1017/cbo9780511623486 · Cited by 6,300
The Evolutionary Fate and Consequences of Duplicate Genes
Lynch, M., & Conery, J. S. (2000) · Science · doi:10.1126/science.290.5494.1151 · Cited by 4,988
Self-citationPreservation of Duplicate Genes by Complementary, Degenerative Mutations
Force, A., Lynch, M., Pickett, F. B., Amores, A., Yan, Y.-L., & Postlethwait, J. (1999) · Genetics · doi:10.1093/genetics/151.4.1531 · Cited by 3,529
Self-citationDrake, J. W., Charlesworth, B., Charlesworth, D., & Crow, J. F. (1998) · Genetics · doi:10.1093/genetics/148.4.1667 · Cited by 1,932
Global Dispersal of Free-Living Microbial Eukaryote Species
Finlay, B. J. (2002) · Science · doi:10.1126/science.1070710 · Cited by 1,832
The Probability of Duplicate Gene Preservation by Subfunctionalization
Lynch, M., & Force, A. G. (2000) · Genetics · doi:10.1093/genetics/154.1.459 · Cited by 1,559
Self-citation(2007) · Wiley eBooks · doi:10.1128/9781555817954 · Cited by 1,311
Alternative splicing: increasing diversity in the proteomic world
Graveley, B. R. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(00)02176-4 · Cited by 1,228
Research works printed but not linked: 2
- B. Charlesworth, in Population Genetics and Molecular Evolution, T. Ohta, K. Aoki, Eds. (Japan Sci. Soc. Press, Tokyo, 1985), pp. 213–232.
- T. R. Gregory, Biol. Rev.76, 65 (2001).
Cited by
Sorted by citations
Items 901–1,000 of 1,001
Durán‐Viseras, A., Sánchez‐Porro, C., Viver, T., Konstantinidis, K. T., & Ventosa, A. (2023) · mSystems · doi:10.1128/msystems.01198-22 · Cited by 16
A first assessment of genome size diversity in Monogonont rotifers
Stelzer, C. (2010) · Hydrobiologia · doi:10.1007/s10750-010-0487-1 · Cited by 16
Caffrey, B. E., Williams, T. A., Jiang, X., Toft, C., Hokamp, K., & Fares, M. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035659 · Cited by 18
Horizontal Transfer Can Drive a Greater Transposable Element Load in Large Populations
Groth, S. B., & Blumenstiel, J. P. (2016) · Journal of Heredity · doi:10.1093/jhered/esw050 · Cited by 16
Hong, H.-H., Lee, H.-G., Jo, J., Kim, H. M., Kim, S., Park, J. Y., Jeon, C. B., Kang, H., Park, M. G., Park, C., et al. (2016) · ALGAE · doi:10.4490/algae.2016.31.12.6 · Cited by 16
Intrinsic adaptive value and early fate of gene duplication revealed by a bottom-up approach
Rodrigo, G., & Fares, M. A. (2018) · eLife · doi:10.7554/elife.29739 · Cited by 17
Patterns of Ancestral Animal Codon Usage Bias Revealed through Holozoan Protists
Southworth, J., Armitage, P., Fallon, B., Dawson, H., Bryk, J., & Carr, M. (2018) · Molecular Biology and Evolution · doi:10.1093/molbev/msy157 · Cited by 16
Dalziel, A. C., Tirbhowan, S., Drapeau, H. F., Power, C., Jonah, L., Gbotsyo, Y. A., & Dion‐Côté, A. (2020) · Evolutionary Applications · doi:10.1111/eva.12975 · Cited by 19
Nonneutral GC3 and Retroelement Codon Mimicry in Phytophthora
Jiang, R. H. Y., & Govers, F. (2006) · Journal of Molecular Evolution · doi:10.1007/s00239-005-0211-3 · Cited by 18
Tai, V., Poon, A. F. Y., Paulsen, I. T., & Palenik, B. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024249 · Cited by 16
Pabic, P. L., Scemama, J., & Stellwag, E. J. (2010) · Evolution & Development · doi:10.1111/j.1525-142x.2009.00390.x · Cited by 16
Genome Size Evolution: Sizing Mammalian Genomes
Redi, C. A., & Capanna, E. (2012) · Cytogenetic and Genome Research · doi:10.1159/000338820 · Cited by 18
Ding, G., Sun, Y., Li, H., Wang, Z., Fan, H., Wang, C., Yang, D., & Li, Y. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm924 · Cited by 16
Crossing fitness valleys via double substitutions within codons
Belinky, F., Sela, I., Rogozin, I. B., & Koonin, E. V. (2019) · BMC Biology · doi:10.1186/s12915-019-0727-4 · Cited by 16
Evolution of complexity in miRNA-mediated gene regulation systems
Takuno, S., & Innan, H. (2008) · Trends in Genetics · doi:10.1016/j.tig.2007.11.002 · Cited by 16
Genome complexity and repetitive DNA in metazoans from extreme marine environments
Fielman, K. T., & Marsh, A. G. (2005) · Gene · doi:10.1016/j.gene.2005.06.035 · Cited by 16
Dockter, R. B., Elzinga, D. B., Geary, B. D., Maughan, P. J., Johnson, L. A., Tumbleson, D. M., Franke, J., Dockter, K., & Stevens, M. R. (2013) · BMC Genetics · doi:10.1186/1471-2156-14-66 · Cited by 16
Codon volatility does not detect selection
Chen, Y., Emerson, J. J., & Martin, T. M. (2005) · Nature · doi:10.1038/nature03223 · Cited by 16
Marino, A., Debaecker, G., Fiston-Lavier, A.-S., Haudry, A., & Nabholz, B. (2024) · eLife · doi:10.7554/elife.100574.1 · Cited by 17
Gene regulatory networks: from correlative models to causal explanations
Maizels, R. J., & Briscoe, J. (2026) · Nature Reviews Genetics · doi:10.1038/s41576-026-00939-1 · Cited by 21
Fortuna, M. A., Zaman, L., Wagner, A., & Bascompte, J. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0431 · Cited by 15
Genome Size Changes by Duplication, Divergence, and Insertion inCaenorhabditisWorms
Adams, P. E., Eggers, V. K., Millwood, J. D., Sutton, J. M., Pienaar, J., & Fierst, J. L. (2023) · Molecular Biology and Evolution · doi:10.1093/molbev/msad039 · Cited by 18
Evolutionary consequences of nascent multicellular life cycles
Pentz, J. T., MacGillivray, K. A., DuBose, J. G., Conlin, P. L., Reinhardt, E. M., Libby, E., & Ratcliff, W. C. (2023) · eLife · doi:10.7554/elife.84336 · Cited by 15
Nuclear genome of dinoflagellates: Size variation and insights into evolutionary mechanisms
Wang, H., Wu, P., Lu, X., Kim, H., Kim, J. H., & Ki, J. (2024) · European Journal of Protistology · doi:10.1016/j.ejop.2024.126061 · Cited by 15
Hjelmen, C. E. (2024) · Genetics · doi:10.1093/genetics/iyae099 · Cited by 20
Harder, C. B., Miyauchi, S., Virágh, M., Kuo, A., Thoen, E., Andreopoulos, B., Lu, D., Skrede, I., Drula, É., Henrissat, B., et al. (2024) · Cell Genomics · doi:10.1016/j.xgen.2024.100586 · Cited by 15
The evolutionary dynamics of genome sizes and repetitive elements in Ensifera (Insecta: Orthoptera)
Yuan, H., Liu, X.-J., Liu, X., Zhao, L., Mao, S.-L., & Huang, Y. (2024) · BMC Genomics · doi:10.1186/s12864-024-10949-0 · Cited by 15
Comparative genomics in the A moebozoa clade
Glöckner, G., & Noegel, A. A. (2012) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2012.00248.x · Cited by 15
The Case Against a Darwinian Origin of Protein Folds
Axe, D. D. (2010) · BIO-Complexity · doi:10.5048/bio-c.2010.1 · Cited by 14
The mode and tempo of genome size evolution in the subgenus Sophophora
Hjelmen, C. E., & Johnston, J. S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173505 · Cited by 15
Chaillon, A., Nakazawa, M., Wertheim, J. O., Little, S. J., Smith, D. M., Mehta, S. R., & Gianella, S. (2017) · Journal of Virology · doi:10.1128/jvi.00769-17 · Cited by 15
Fitness Landscape of the Fission Yeast Genome
Grech, L., Jeffares, D. C., Sadée, C., Rodríguez‐López, M., Bitton, D. A., Hoti, M., Biagosch, C., Aravani, D., Speekenbrink, M., Illingworth, C. J. R., et al. (2019) · Molecular Biology and Evolution · doi:10.1093/molbev/msz113 · Cited by 14
Hjelmen, C. E., Blackmon, H., Holmes, V. R., Burrus, C., & Johnston, J. S. (2019) · G3 Genes Genomes Genetics · doi:10.1534/g3.119.400560 · Cited by 15
Out of the testis, into the ovary: biased outcomes of gene duplication and deletion in Drosophila
Assis, R. (2019) · Evolution · doi:10.1111/evo.13820 · Cited by 13
Treindl, A. D., Stapley, J., Winter, D. J., Cox, M. P., & Leuchtmann, A. (2021) · Genomics · doi:10.1016/j.ygeno.2021.11.009 · Cited by 15
Genome size does not influence extinction risk in the world's amphibians
Pincheira‐Donoso, D., Harvey, L. P., Johnson, J. V., Hudson, D. W., Finn, C., Goodyear, L. E. B., Guirguis, J., Hyland, E. M., & Hodgson, D. J. (2022) · Functional Ecology · doi:10.1111/1365-2435.14247 · Cited by 15
Fernández, A., Tzeng, Y.-H., & Hsu, S. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-604 · Cited by 15
Jaramillo‐Correa, J. P., Aguirre‐Planter, E., Eguiarte, L. E., Khasa, D. P., & Bousquet, J. (2013) · Journal of Molecular Evolution · doi:10.1007/s00239-013-9547-2 · Cited by 15
Schielzeth, H., Streitner, C., Lampe, U., Franzke, A., & Reinhold, K. (2014) · Evolution · doi:10.1111/evo.12522 · Cited by 15
Fungal Genes in Context: Genome Architecture Reflects Regulatory Complexity and Function
Noble, L. M., & Andrianopoulos, A. (2013) · Genome Biology and Evolution · doi:10.1093/gbe/evt077 · Cited by 16
Watts, P. C., Lundholm, N., Ribeiro, S., & Ellegaard, M. (2013) · Biology Letters · doi:10.1098/rsbl.2013.0849 · Cited by 15
Tanti, G. K., Srivastava, R., Kalluri, S. R., Nowak, C., & Hemmer, B. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00333 · Cited by 15
Genome Comparison of Bacterial Pathogens
Wassenaar, T. M., Bohlin, J., Binnewies, T. T., & Ussery, D. W. (2009) · Genome dynamics · doi:10.1159/000235759 · Cited by 15
Reis, M., Sousa-Guimarães, S., Vieira, C. P., Sunkel, C. E., & Vieira, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017512 · Cited by 15
Kvamme, B. O., Kongshaug, H., & Nilsen, F. (2005) · Gene · doi:10.1016/j.gene.2005.03.011 · Cited by 15
Xie, D., Ye, P., Ma, Y., Li, Y., Liu, X., Sarkies, P., & Zhao, Z. (2022) · Genome Research · doi:10.1101/gr.277205.122 · Cited by 15
Centromere drive may propel the evolution of chromosome and genome size in plants
Plačková, K., Bureš, P., Lysák, M. A., & Zedek, F. (2024) · Annals of Botany · doi:10.1093/aob/mcae149 · Cited by 14
Evolution, Complexity, and Life History Theory
Veit, W., Gascoigne, S. J. L., & Salguero‐Gómez, R. (2025) · Biological Theory · doi:10.1007/s13752-024-00487-z · Cited by 17
Centrophilic Retrotransposons of Plant Genomes
Bousios, A., Kakutani, T., & Henderson, I. R. (2025) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-083123-082220 · Cited by 16
A new look at genome size, evolutionary duration and genetic variation in salamanders
Herrick, J., & Sclavi, B. (2014) · Comptes Rendus Palevol · doi:10.1016/j.crpv.2014.06.002 · Cited by 14
Prediction of Subgenome Additive and Interaction Effects in Allohexaploid Wheat
Santantonio, N., Jannink, J., & Sorrells, M. E. (2018) · G3 Genes Genomes Genetics · doi:10.1534/g3.118.200613 · Cited by 14
Transposition burst of mariner-like elements in the sequenced genome of Rhodnius prolixus
Fernández-Medina, R. D., Granzotto, A., Ribeiro, J. M. C., & Carareto, C. M. A. (2015) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2015.09.003 · Cited by 14
Vera, M., Bello, X., Álvarez‐Dios, J. A., Pardo, B. G., Sanchez, L. E., Carlsson, J., Carlsson, J. E. L., Bartolomé, C., Maside, X., & Martı́nez, P. (2015) · Marine Genomics · doi:10.1016/j.margen.2015.08.006 · Cited by 14
DNA clustering and genome complexity
Dios, F., Barturen, G., Lebrón, R., Rueda, A., Hackenberg, M., & Oliver, J. L. T. (2014) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2014.08.011 · Cited by 14
ENZYME ISOFORMS MAY INCREASE PHENOTYPIC ROBUSTNESS
Tomaiuolo, M., Bertram, R., & Houle, D. (2008) · Evolution · doi:10.1111/j.1558-5646.2008.00483.x · Cited by 13
Sizing up Arabidopsis genome evolution
Wright, S., & Ågren, J. A. (2011) · Heredity · doi:10.1038/hdy.2011.47 · Cited by 14
The Random Nature of Genome Architecture: Predicting Open Reading Frame Distributions
McCoy, M. W., Allen, A. P., & Gillooly, J. F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006456 · Cited by 14
Madison-Villar, M. J., Sun, C., Lau, N. C., Settles, M. L., & Mueller, R. L. (2016) · Journal of Molecular Evolution · doi:10.1007/s00239-016-9759-3 · Cited by 13
A century of bias in genetics and evolution
Hurst, L. D. (2019) · Heredity · doi:10.1038/s41437-019-0194-2 · Cited by 13
Vertebrate Genome Size and the Impact of Transposable Elements in Genome Evolution
Biscotti, M. A., Carducci, F., Olmo, E., & Canapa, A. (2019) · Springer eBooks · doi:10.1007/978-3-030-30363-1_12 · Cited by 14
Glansdorff, N., Xu, Y., & Labedan, B. (2009) · Journal of Molecular Evolution · doi:10.1007/s00239-009-9277-7 · Cited by 14
Clément, Y., Tavares, R., & Marais, G. A. B. (2006) · Gene · doi:10.1016/j.gene.2006.05.032 · Cited by 14
Emergence and evolution of protein-coding de novo genes
Bornberg‐Bauer, E., & Eicholt, L. A. (2026) · Nature Reviews Genetics · doi:10.1038/s41576-025-00929-9 · Cited by 15
Ji, Y., Feng, S., Wu, L., Fang, Q., Brüniche–Olsen, A., DeWoody, J. A., Cheng, Y., Zhang, D., Hao, Y., Song, G., et al. (2022) · Science Advances · doi:10.1126/sciadv.abo0099 · Cited by 16
Genome Streamlining: Effect of Mutation Rate and Population Size on Genome Size Reduction
Luiselli, J., Rouzaud-Cornabas, J., Lartillot, N., & Beslon, G. (2024) · Genome Biology and Evolution · doi:10.1093/gbe/evae250 · Cited by 13
Comparative and evolutionary analysis of chloroplast genomes from five rare Styrax species
Zheng, H.-Z., Peng, G.-X., Zhao, L.-C., Dai, W., Xu, M.-H., Xu, X., & Tang, M. (2025) · BMC Genomics · doi:10.1186/s12864-025-11629-3 · Cited by 13
Relaxed Purifying Selection is Associated with an Accumulation of Transposable Elements in Flies
Mérel, V., Tricou, T., Burlet, N., & Haudry, A. (2025) · Molecular Biology and Evolution · doi:10.1093/molbev/msaf111 · Cited by 13
The dynamic genomes of Hydra and the anciently active repeat complement of animal chromosomes
Kon‐Nanjo, K., Kon, T., Koubková-Yu, T. C.-T., Rodriguez‐Terrones, D., Falcon, F., Martínez, D. E., Steele, R. E., Tanaka, E. M., Holstein, T. W., & Simakov, O. (2025) · Genome biology · doi:10.1186/s13059-025-03653-z · Cited by 14
What can we learn from genomics approaches in marine ecology? From sequences to eco‐systems biology!
Möck, T., & Kirkham, A. R. (2011) · Marine Ecology · doi:10.1111/j.1439-0485.2011.00479.x · Cited by 14
Lineage-Specific Differences in the Amino Acid Substitution Process
Huzurbazar, S. V., Kolesov, G., Massey, S. E., Harris, K. C., Churbanov, A., & Liberles, D. A. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.11.075 · Cited by 13
Serra, F., Becher, V., & Dopazo, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063915 · Cited by 13
Villegas, P., Muñoz, M. A., & Bonachela, J. A. (2020) · Journal of The Royal Society Interface · doi:10.1098/rsif.2019.0845 · Cited by 13
Effect of Phenotype Selection on Genome Size Variation in Two Species of Diptera
Hjelmen, C. E., Parrott, J. J., Srivastav, S. P., McGuane, A. S., Ellis, L. L., Stewart, A. D., Johnston, J. S., & Tarone, A. M. (2020) · Genes · doi:10.3390/genes11020218 · Cited by 13
Recurrent sequence evolution after independent gene duplication
von der Dunk, S. H. A., & Snel, . (2020) · BMC Evolutionary Biology · doi:10.1186/s12862-020-01660-1 · Cited by 12
Sahoo, L., Barat, A., Sahoo, S. K., Sahoo, B., Das, G., Das, P., Sundaray, J. K., & Swain, S. K. (2020) · Turkish Journal of Fisheries and Aquatic Sciences · doi:10.4194/1303-2712-v21_1_02 · Cited by 13
Robin, A. N., Denton, K. K., Lowell, E. S. H., Dulay, T., Ebrahimi, S., Johnson, G. C., Mai, D., O’Fallon, S., Philson, C. S., Speck, H. P., et al. (2021) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2021.711556 · Cited by 14
Lifestyles shape genome size and gene content in fungal pathogens
Fijarczyk, A., Hessenauer, P., Hamelin, R. C., & Landry, C. R. (2025) · eLife · doi:10.7554/elife.104975.4 · Cited by 13
The implications of satellite DNA instability on cellular function and evolution
Flynn, J. M., & Yamashita, Y. M. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.10.005 · Cited by 15
General Trends in the Utilization of Structural Factors Contributing to Biological Complexity
Yang, D. C., Zhong, F., Li, D., Liu, Z., Wei, H., Jiang, Y., & He, F. (2012) · Molecular Biology and Evolution · doi:10.1093/molbev/mss064 · Cited by 13
A Dynamic Model for the Evolution of Protein Structure
Tal, G., Boca, S. M., Mittenthal, J. E., & Caetano‐Anollés, G. (2016) · Journal of Molecular Evolution · doi:10.1007/s00239-016-9740-1 · Cited by 14
Computational Evolution Experiments Reveal a Net Loss of Genetic Information Despite Selection
Nelson, C. W., & Sanford, J. C. (2013) · doi:10.1142/9789814508728_0014 · Cited by 13
Increase in Complexity and Information through Molecular Evolution
Schuster, P. M. (2016) · Entropy · doi:10.3390/e18110397 · Cited by 13
Ji, Y., & DeWoody, J. A. (2016) · Evolutionary Biology · doi:10.1007/s11692-016-9405-4 · Cited by 13
Does Large Genome Size Limit Speciation in Endemic Island Floras?
Kapralov, M. V., & Filatov, D. A. (2011) · Journal of Botany · doi:10.1155/2011/458684 · Cited by 13
Relationship between gene duplicability and diversifiability in the topology of biochemical networks
Guo, Z., Jiang, W. G., Lages, N., Borcherds, W. M., & Wang, D. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-577 · Cited by 13
Population Dynamics Through the Lens of Extreme Environments
Whitaker, R. J. (2005) · Reviews in Mineralogy and Geochemistry · doi:10.2138/rmg.2005.59.11 · Cited by 14
The Fruits of Tropical Plant Genomics
Paterson, A. H., Felker, P., Hubbell, S. P., & Ming, R. (2008) · Tropical Plant Biology · doi:10.1007/s12042-007-9004-8 · Cited by 13
The multiple directions of evolutionary change
Rasskin‐Gutman, D., & Esteve‐Altava, B. (2008) · BioEssays · doi:10.1002/bies.20766 · Cited by 13
Genetic diversity and population structure of Rheum tanguticum (Dahuang) in China
Zhang, X., Liu, Y., Gu, X., Guo, Z.-Z., Li, L., Song, X., Liu, S., Zang, Y., Li, Y., Liu, C., et al. (2014) · Chinese Medicine · doi:10.1186/1749-8546-9-26 · Cited by 13
Genomic Dynamics of Transposable Elements in the Western Clawed Frog (Silurana tropicalis)
Shen, J. J., Dushoff, J. G., Bewick, A. J., Chain, F. J. J., & Evans, B. J. (2013) · Genome Biology and Evolution · doi:10.1093/gbe/evt065 · Cited by 13
Zhao, C., Zhang, X., Liu, C., Huan, P., Li, F., Xiang, J., & Huang, C. (2011) · Chinese Journal of Oceanology and Limnology · doi:10.1007/s00343-012-1159-y · Cited by 14
The mutation–drift balance in spatially structured populations
Schneider, D. M., Martins, A. B., & de Aguiar, M. A. M. (2016) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2016.04.024 · Cited by 13
Somatizing the transposons action
Loreto, É. L. S., & Pereira, C. M. (2017) · Mobile Genetic Elements · doi:10.1080/2159256x.2017.1314236 · Cited by 13
Ouchane, S., Nitschke, W., Bianco, P., Verméglio, A., & Astier, C. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04685.x · Cited by 13
Emergence of distinct syntenic density regimes is associated with early metazoan genomic transitions
Robert, N. S. M., Sarigol, F., Zimmermann, B., Meyer, A., Voolstra, C. R., & Simakov, O. (2022) · BMC Genomics · doi:10.1186/s12864-022-08304-2 · Cited by 12
Genomic Diversity Illuminates the Environmental Adaptation of Drosophila suzukii
Feng, S., Degrey, S. P., Guédot, C., Schoville, S. D., & Pool, J. E. (2024) · Genome Biology and Evolution · doi:10.1093/gbe/evae195 · Cited by 12
Du, Z., Gelembiuk, G. W., Moss, W. E., Tritt, A., & Lee, C. E. (2024) · Genomics Proteomics & Bioinformatics · doi:10.1093/gpbjnl/qzae066 · Cited by 14
Jiang, J., Chen, J., Li, X.-T., Wang, L., Mao, J., Wang, B., & Guo, Y. (2025) · Nature Communications · doi:10.1038/s41467-025-58021-z · Cited by 12
Feng, S., Ollivier, J. F., Swain, P. S., & Soyer, O. S. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv595 · Cited by 12
Axe, D. D. (2010) · BIO-Complexity · doi:10.5048/bio-c.2010.4 · Cited by 12
Metadata
- Authors
- Lynch, M., & Conery, J. S.
- Affiliations
- University of Oregon (US)
- Corresponding author
- Lynch, Michael
- Venue
- Science
- Published
- 2003-11-21
- Volume
- 302
- Issue
- 5649
- Pages
- 1401-1404
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1988714210
- Cited by
- 1,698
- References
- 32
- Citations by year
- 2026: 63 · 2025: 70 · 2024: 95 · 2023: 53 · 2022: 58 · 2021: 82 · 2020: 80 · 2019: 70 · 2018: 70 · 2017: 71 · 2016: 89 · 2015: 65 · 2014: 68 · 2013: 77 · 2012: 90
- FWCI
- 69.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- genome complexity, eukaryotic genome evolution, gene duplication, spliceosomal introns, mobile genetic elements, population size reduction, organism size, effective population size, prokaryotes, multicellularity, phenotypic complexity
- MeSH terms
- Alleles, Animals, Bacteria, Body Constitution, Fungi, Humans, Introns, Invertebrates, Mutation, Phylogeny, Plants, Population Density, Recombination, Genetic, Selection, Genetic, Genetic Variation, Vertebrates, Genome, Spliceosomes, Evolution, Molecular, Interspersed Repetitive Sequences, Gene Duplication, Gene Silencing, Genetic Drift, Eukaryota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review