The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
The Origins of Genome Complexity
Abstract
Complete genomic sequences from diverse phylogenetic lineages reveal notable increases in genome complexity from prokaryotes to multicellular eukaryotes. The changes include gradual increases in gene number, resulting from the retention of duplicate genes, and more abrupt increases in the abundance of spliceosomal introns and mobile genetic elements. We argue that many of these modifications emerged passively in response to the long-term population-size reductions that accompanied increases in organism size. According to this model, much of the restructuring of eukaryotic genomes was initiated by nonadaptive processes, and this in turn provided novel substrates for the secondary evolution of phenotypic complexity by natural selection. The enormous long-term effective population sizes of prokaryotes may impose a substantial barrier to the evolution of complex genomes and morphologies.
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“Given the extremely high costs of building and maintaining nervous systems [10–12], neutral evolutionary processes are arguably less prevalent during nervous system evolution than for example in genome evolution [13].”
From Origin and early evolution of neural circuits for the control of ciliary locomotion (2011) · cites this paper as [13]
Citations
Cites
Ohno, S. (1970) · doi:10.1007/978-3-642-86659-3 · Cited by 7,833
The Neutral Theory of Molecular Evolution
Kimura, M. (1979) · Scientific American · doi:10.1038/scientificamerican1179-98 · Cited by 7,687
The Neutral Theory of Molecular Evolution
Kimura, M. (1983) · Cambridge University Press eBooks · doi:10.1017/cbo9780511623486 · Cited by 6,300
The Evolutionary Fate and Consequences of Duplicate Genes
Lynch, M., & Conery, J. S. (2000) · Science · doi:10.1126/science.290.5494.1151 · Cited by 4,988
Self-citationPreservation of Duplicate Genes by Complementary, Degenerative Mutations
Force, A., Lynch, M., Pickett, F. B., Amores, A., Yan, Y.-L., & Postlethwait, J. (1999) · Genetics · doi:10.1093/genetics/151.4.1531 · Cited by 3,529
Self-citationDrake, J. W., Charlesworth, B., Charlesworth, D., & Crow, J. F. (1998) · Genetics · doi:10.1093/genetics/148.4.1667 · Cited by 1,932
Global Dispersal of Free-Living Microbial Eukaryote Species
Finlay, B. J. (2002) · Science · doi:10.1126/science.1070710 · Cited by 1,832
The Probability of Duplicate Gene Preservation by Subfunctionalization
Lynch, M., & Force, A. G. (2000) · Genetics · doi:10.1093/genetics/154.1.459 · Cited by 1,559
Self-citation(2007) · Wiley eBooks · doi:10.1128/9781555817954 · Cited by 1,311
Alternative splicing: increasing diversity in the proteomic world
Graveley, B. R. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(00)02176-4 · Cited by 1,228
Research works printed but not linked: 2
- B. Charlesworth, in Population Genetics and Molecular Evolution, T. Ohta, K. Aoki, Eds. (Japan Sci. Soc. Press, Tokyo, 1985), pp. 213–232.
- T. R. Gregory, Biol. Rev.76, 65 (2001).
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RNA processing and degradation mechanisms shaping the mitochondrial transcriptome of budding yeasts
Golik, P. (2024) · IUBMB Life · doi:10.1002/iub.2779 · Cited by 9
Metadata
- Authors
- Lynch, M., & Conery, J. S.
- Affiliations
- University of Oregon (US)
- Corresponding author
- Lynch, Michael
- Venue
- Science
- Published
- 2003-11-21
- Volume
- 302
- Issue
- 5649
- Pages
- 1401-1404
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1988714210
- Cited by
- 1,698
- References
- 32
- Citations by year
- 2026: 63 · 2025: 70 · 2024: 95 · 2023: 53 · 2022: 58 · 2021: 82 · 2020: 80 · 2019: 70 · 2018: 70 · 2017: 71 · 2016: 89 · 2015: 65 · 2014: 68 · 2013: 77 · 2012: 90
- FWCI
- 69.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- genome complexity, eukaryotic genome evolution, gene duplication, spliceosomal introns, mobile genetic elements, population size reduction, organism size, effective population size, prokaryotes, multicellularity, phenotypic complexity
- MeSH terms
- Alleles, Animals, Bacteria, Body Constitution, Fungi, Humans, Introns, Invertebrates, Mutation, Phylogeny, Plants, Population Density, Recombination, Genetic, Selection, Genetic, Genetic Variation, Vertebrates, Genome, Spliceosomes, Evolution, Molecular, Interspersed Repetitive Sequences, Gene Duplication, Gene Silencing, Genetic Drift, Eukaryota
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