The DOI matches its Crossref record.
Anterior-Posterior Guidance of Commissural Axons by Wnt-Frizzled Signaling
Abstract
Commissural neurons in the mammalian dorsal spinal cord send axons ventrally toward the floor plate, where they cross the midline and turn anteriorly toward the brain; a gradient of chemoattractant(s) inside the spinal cord controls this turning. In rodents, several Wnt proteins stimulate the extension of commissural axons after midline crossing (postcrossing). We found that Wnt4 messenger RNA is expressed in a decreasing anterior-to-posterior gradient in the floor plate, and that a directed source of Wnt4 protein attracted postcrossing commissural axons. Commissural axons in mice lacking the Wnt receptor Frizzled3 displayed anterior-posterior guidance defects after midline crossing. Thus, Wnt-Frizzled signaling guides commissural axons along the anterior-posterior axis of the spinal cord.
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Cited by
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
Vascular Development in the Retina and Inner Ear
Xu, Q., Wang, Y., Dabdoub, A., Smallwood, P. M., Williams, J., Woods, C., Kelley, M. W., Jiang, L., Tasman, W., Zhang, K., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00216-8 · Cited by 875
Self-citationBiomolecular gradients in cell culture systems
Keenan, T. M., & Folch, A. (2008) · Lab Chip · doi:10.1039/b711887b · Cited by 596
WNTS in the vertebrate nervous system: from patterning to neuronal connectivity
Ciani, L., & Salinas, P. C. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1665 · Cited by 543
Wang, Y., Guo, N., & Nathans, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4698-05.2005 · Cited by 503
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Metadata
- Authors
- Lyuksyutova, A. I., Lu, C.-C., Milanesio, N., King, L. A., Guo, N., Wang, Y., Nathans, J., Tessier-Lavigne, M., & Zou, Y.
- Venue
- Science
- Published
- 2003-12-12
- Volume
- 302
- Issue
- 5652
- Pages
- 1984-1988
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1989184804
- Cited by
- 557
- References
- 0
- FWCI
- 11.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lyuksyutova, A. I., Lu, C.-C., Milanesio, N., King, L. A., Guo, N., Wang, Y., Nathans, J., Tessier-Lavigne, M., & Zou, Y. (2003). Anterior-Posterior Guidance of Commissural Axons by Wnt-Frizzled Signaling. Science. https://doi.org/10.1126/science.1089610
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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