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ATP-Driven Exchange of Histone H2AZ Variant Catalyzed by SWR1 Chromatin Remodeling Complex
Open accessAbstract
The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. How histone variants such as H2AZ are incorporated into nucleosomes has been obscure. We have found that Swr1, a Swi2/Snf2-related adenosine triphosphatase, is the catalytic core of a multisubunit, histone-variant exchanger that efficiently replaces conventional histone H2A with histone H2AZ in nucleosome arrays. Swr1 is required for the deposition of histone H2AZ at specific chromosome locations in vivo, and Swr1 and H2AZ commonly regulate a subset of yeast genes. These findings define a previously unknown role for the adenosine triphosphate–dependent chromatin remodeling machinery.
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Cited by
The molecular hallmarks of epigenetic control
Allis, C. D., & Jenuwein, T. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.59 · Cited by 2,809
The Biology of Chromatin Remodeling Complexes
Clapier, C. R., & Cairns, B. R. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.062706.153223 · Cited by 2,380
Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes
Clapier, C. R., Iwasa, J., Cairns, B. R., & Peterson, C. L. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.26 · Cited by 1,305
Chromatin remodelling during development
Ho, L., & Crabtree, G. R. (2010) · Nature · doi:10.1038/nature08911 · Cited by 1,114
H2A.Z-containing nucleosomes mediate the thermosensory response in Arabidopsis
Kumar, S. V., & Wigge, P. A. (2010) · Cell · doi:10.1016/j.cell.2009.11.006 · Cited by 971
Metadata
- Authors
- Mizuguchi, G., Shen, X., Landry, J., Wu, W.-H., Sen, S., & Wu, C.
- Venue
- Science
- Published
- 2004-01-16
- Volume
- 303
- Issue
- 5656
- Pages
- 343-348
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2029388127
- Cited by
- 1,309
- References
- 0
- FWCI
- 24.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Mizuguchi, G., Shen, X., Landry, J., Wu, W.-H., Sen, S., & Wu, C. (2004). ATP-Driven Exchange of Histone H2AZ Variant Catalyzed by SWR1 Chromatin Remodeling Complex. Science. https://doi.org/10.1126/science.1090701
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