The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Instructive Role of Wnt/ß-Catenin in Sensory Fate Specification in Neural Crest Stem Cells
Abstract
Wnt signaling has recently emerged as a key factor in controlling stem cell expansion. In contrast, we show here that Wnt/β-catenin signal activation in emigrating neural crest stem cells (NCSCs) has little effect on the population size and instead regulates fate decisions. Sustained β-catenin activity in neural crest cells promotes the formation of sensory neural cells in vivo at the expense of virtually all other neural crest derivatives. Moreover, Wnt1 is able to instruct early NCSCs (eNCSCs) to adopt a sensory neuronal fate in a β-catenin–dependent manner. Thus, the role of Wnt/β-catenin in stem cells is cell-type dependent.
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Cites
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
A role for Wnt signalling in self-renewal of haematopoietic stem cells
Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159
Etchevers, H. C., Vincent, C., Douarin, N. M. L., & F. Couly, G. (2001) · Development · doi:10.1242/dev.128.7.1059 · Cited by 657
Cited by
Wnt signalling in stem cells and cancer
Reya, T., & Clevers, H. (2005) · Nature · doi:10.1038/nature03319 · Cited by 3,666
WNT and β-catenin signalling: diseases and therapies
Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763
Wnt signalling and its impact on development and cancer
Klaus, A., & Birchmeier, W. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2389 · Cited by 1,595
Chong, Z. Z., Li, F., & Maiese, K. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.02.004 · Cited by 536
Pax3 functions at a nodal point in melanocyte stem cell differentiation
Lang, D., Lu, M. M., Huang, L., Engleka, K. A., Zhang, M., Chu, E. Y., Lipner, S., Skoultchi, A., Millar, S. E., & Epstein, J. A. (2005) · Nature · doi:10.1038/nature03292 · Cited by 397
Metadata
- Authors
- Lee, H.-Y., Kléber, M., Hari, L., Brault, V., Suter, U., Taketo, M. M., Kemler, R., & Sommer, L.
- Venue
- Science
- Published
- 2004-02-13
- Volume
- 303
- Issue
- 5660
- Pages
- 1020-1023
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2150295764
- Cited by
- 418
- References
- 3
- FWCI
- 15.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, H.-Y., Kléber, M., Hari, L., Brault, V., Suter, U., Taketo, M. M., Kemler, R., & Sommer, L. (2004). Instructive Role of Wnt/ß-Catenin in Sensory Fate Specification in Neural Crest Stem Cells. Science. https://doi.org/10.1126/science.1091611
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