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Cited by 775

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Molecular Evolution of the SARS Coronavirus During the Course of the SARS Epidemic in China

The Chinese SARS Molecular Epidemiology Consortium·2004·Science

Abstract

Sixty-one SARS coronavirus genomic sequences derived from the early, middle, and late phases of the severe acute respiratory syndrome (SARS) epidemic were analyzed together with two viral sequences from palm civets. Genotypes characteristic of each phase were discovered, and the earliest genotypes were similar to the animal SARS-like coronaviruses. Major deletions were observed in the Orf8 region of the genome, both at the start and the end of the epidemic. The neutral mutation rate of the viral genome was constant but the amino acid substitution rate of the coding sequences slowed during the course of the epidemic. The spike protein showed the strongest initial responses to positive selection pressures, followed by subsequent purifying selection and eventual stabilization.

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Crossref · 10.1126/science.1092002

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Metadata

Authors
The Chinese SARS Molecular Epidemiology Consortium
Venue
Science
Published
2004-03-12
Volume
303
Issue
5664
Pages
1666-1669
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W96734778
Cited by
775
References
2
FWCI
47.44
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.