Cited by 733Metabolism, Diabetes, and CancerPancreatic function and diabetesAdipokines, Inflammation, and Metabolic Diseases

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Insulin Signaling in Health and Disease

White, Morris F.·2003·Science

DOI 10.1126/science.1092952

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Abstract

The signaling pathways used by insulin have been identified [M. White, Insulin Signaling Pathway, Sci. STKE (Connections Map, as seen November 2003), http://stke.sciencemag.org/cgi/cm/cmp_12069]. Now our challenge is to understand how the failure of these signals is associated with obesity and the progressive failure of pancreatic beta cells that leads to diabetes. Whether better management of chronic inflammation can improve insulin action is an important area of investigation. Drugs that stimulate IRS2 (insulin receptor substrate protein 2) synthesis or signaling might be a good starting point. This knowledge will lead to rational strategies that prevent or cure diabetes.

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M. White Insulin Signaling Pathway Sci. STKE (Connections Map as seen November 2003) http://stke.sciencemag.org/cgi/cm/cmp_12069.
G. S. Hotamisligil, B. M. Spiegelman, Science259, 87 (1999).
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Authors: White, M. F.
Affiliations: Joslin Diabetes Center (US)
Corresponding author: White, Morris F.
ORCID: White, Morris F.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2003-12-05
Volume: 302
Issue: 5651
Pages: 1710-1711
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1092952
OpenAlex: W2115177689
Cited by: 733
References: 19
Citations by year: 2026: 7 · 2025: 17 · 2024: 13 · 2023: 21 · 2022: 24 · 2021: 35 · 2020: 32 · 2019: 30 · 2018: 36 · 2017: 35 · 2016: 39 · 2015: 47 · 2014: 35 · 2013: 39 · 2012: 50
FWCI: 9.65
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: insulin signaling, insulin resistance, obesity, type 2 diabetes, pancreatic beta-cell failure, chronic inflammation, insulin receptor substrate 2
MeSH terms: Animals, Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Inflammation, Insulin, Insulin Resistance, Islets of Langerhans, Models, Biological, Obesity, Phosphoproteins, Phosphorylation, Receptor, Insulin, Somatomedins, Signal Transduction, Cytokines, Intracellular Signaling Peptides and Proteins, Mice, Insulin Receptor Substrate Proteins

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