The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Insulin Signaling in Health and Disease
Abstract
The signaling pathways used by insulin have been identified [M. White, Insulin Signaling Pathway, Sci. STKE (Connections Map, as seen November 2003), http://stke.sciencemag.org/cgi/cm/cmp_12069]. Now our challenge is to understand how the failure of these signals is associated with obesity and the progressive failure of pancreatic beta cells that leads to diabetes. Whether better management of chronic inflammation can improve insulin action is an important area of investigation. Drugs that stimulate IRS2 (insulin receptor substrate protein 2) synthesis or signaling might be a good starting point. This knowledge will lead to rational strategies that prevent or cure diabetes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Physiologically, IRS-1 is phosphorylated at tyrosine residues by the tyrosine kinase activity of the IR, which activates downstream signaling in the insulin pathway (Araki et al., 1994; White, 2003).”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as White, 2003
Citations
Cites
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Global and societal implications of the diabetes epidemic
Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003) · Nature · doi:10.1038/nature01705 · Cited by 3,176
Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., & Ruvkun, G. (1997) · Nature · doi:10.1038/40194 · Cited by 1,935
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J., & White, M. F. (1991) · Nature · doi:10.1038/352073a0 · Cited by 1,574
Self-citationInsulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
Puigserver, P., Rhee, J., Donovan, J., Walkey, C. J., Yoon, J. C., Oriente, F., Kitamura, Y., Altomonte, J., Dong, H., Accili, D., et al. (2003) · Nature · doi:10.1038/nature01667 · Cited by 1,487
Aguirre, V., Werner, E. D., Giraud, J., Lee, Y. H., Shoelson, S. E., & White, M. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m101521200 · Cited by 1,010
Self-citationFrasca, F., Pandini, G., Scalia, P., Sciacca, L., Mineo, R., Costantino, A., Goldfine, I. D., Belfiore, A., & Vigneri, R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3278 · Cited by 897
Savkur, R. S., Philips, A. V., & Cooper, T. A. (2001) · Nature Genetics · doi:10.1038/ng704 · Cited by 795
Research works printed but not linked: 3
- M. White Insulin Signaling Pathway Sci. STKE (Connections Map as seen November 2003) http://stke.sciencemag.org/cgi/cm/cmp_12069.
- G. S. Hotamisligil, B. M. Spiegelman, Science259, 87 (1999).
- D. L. Krebs, D. J. Hilton, Sci. STKE.2003, E6 (2003).
Cited by
Sorted by citations
Items 601–700 of 732
Papizan, J. B. (2007) · Cited by 1
Qi, Y., Guo, X., & Guo, S. (2015) · Springer eBooks · doi:10.1007/978-3-319-12125-3_28-1 · Cited by 1
Body Size, Obesity, and Colorectal Cancer
Slattery, M. L., & McTiernan, A. (2005) · Nutrition and disease prevention · doi:10.1201/9781420026641.ch15 · Cited by 1
Insulin Signaling, Epigenetics, and Human Diseases
Chruvattil, R., Belani, M., Patel, T. P., & Gupta, S. S. (2017) · Wiley eBooks · doi:10.1002/9783527697274.ch18 · Cited by 1
From insulin action to hormonal resistance: old to recent molecular mechanisms
Lorenzo, M., & Benito, M. (2009) · Dialnet (Universidad de la Rioja) · Cited by 1
Primary cilia sensitize insulin receptor-mediated negative feedback in pancreatic β cellsPreprint
Li, Y., Shrestha, P. K., & Wu, Y. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.02.408914 · Cited by 1
“Cells were then blocked in 1% BSA for 20 minutes before being incubated in a primary antibody against acetylated α tubulin (1:4000 dilution, clone 6-11B-1, Sigma-Aldrich, St. Louis, MO, USA), GFP (1:1000, clone A11120, Thermo Fisher, Waltham, MA), Arl13b (1:500, Proteintech, Rosemont, IL, USA), phospho-IR/ IGF1R (Tyr1…”
BackgroundInfluentialThe impact of Heat Shock Protein 72 expression on mitochondrial function and insulin action
Song, X. M. (2014) · eScholarship (California Digital Library) · Cited by 1
A novel neurophysiologically-inspired self-organizing cerebellar memory framework
Sintiani, D. T. (2008) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/41119 · Cited by 1
The Liver and Insulin Resistance: The Important Convergence of Endocrinology and Hepatology
Chang, C., Whitt, K. N., Liu, Z., & Caldwell, S. H. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-192-5_13
“Tyrosine kinase-mediated phosphorylation of the insulin receptor substrate (IRS) then triggers a cascade of pathways that differ depending upon the target tissue and the specific IRS type (6 , 7 ) . Four different types of IRS proteins have been identified: IRS 1 (skeletal muscle), IRS 2 (liver), IRS 3 (adipose, β -ce…”
BackgroundRegulation of Dual Leucine Zipper Kinase (DLK) by Prediabetic Signals
Babaeikelishomi, R. (2013) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4117
Müller, G. A. (2015) · Springer eBooks · doi:10.1007/978-3-319-05392-9_157
Wilson, J. R. (2012) · KU ScholarWorks (The University of Kansas)
Itkonen, S. T. (2015) · Työväentutkimus Vuosikirja
Perinatal programming of appetite regulation and metabolic health
Dellschaft, N. S. (2012) · Nottingham ePrints (University of Nottingham)
Glund, S. (2007) · Figshare
Skeletal muscle metabolic flexibility : The roles of AMP-activated protein kinase and calcineurin
Long, Y. C. (2007) · Figshare
The Janus Face of Insulin in Brain
Duarte, A. I., Candeias, E., Correia, S. C., Santos, R. X., Carvalho, C., Cardoso, S., Plácido, A. I., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2013) · Wiley eBooks · doi:10.1002/9781118395318.ch5
Ramesh, N. (2015) · University Library - University of Saskatchewan (University of Saskatchewan)
Ahlsén, M. (2006) · Figshare
Characterization of Drosophila Lnk
Werz, C. (2009) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-a-006073429
Modulation of Cognition by Insulin and Aging: Implications for Alzheimer Disease
Solas, M., & Ramírez, M. J. (2013) · Wiley eBooks · doi:10.1002/9781118395318.ch6
INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3
Ahlsén, M. (2007) · Figshare
Queen Honeybee and Me: Forever Young? Conserved Pathways for Longevity
Knäblein, J., & Huber, R. (2013) · Wiley eBooks · doi:10.1002/9783527669417.ch26
Post-Translational Modification Profiling of Burn-Induced — Insulin Resistance and Muscle Wasting
Lu, X., Ronald, G., & Alan, J. F. (2013) · InTech eBooks · doi:10.5772/54849
“Glucose intolerance and elevated insulin levels may contribute to hyperglycemia, even in non-diabetic patients [12,13,14,15,16,17].”
Methodological and Clinical Studies on Insulin Resistance in Childhood
Rössner, S. M. (2011) · Figshare
Cellular Models for the Study of Type 2 Diabetes
Lorenzo, M., Valverde, Á. M., & Benito, M. (2005) · Elsevier eBooks · doi:10.1016/b978-84-8174-892-5.50003-6
From the pancreatic beta cell to the endothelium:Pathophysiological aspects of Type 2 Diabetes
Nitert, M. D. (2007) · Lund University Publications (Lund University)
Ca2+ fluxes and insulin action in cardiac and skeletal muscles
Lanner, J. T. (2008) · Figshare
Tratamiento no farmacológico y farmacológico de la diabetes mellitus
Cabezas-Cerrato, J., & Agrícola, J. M. C. (2004) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/s0211-3449(04)70148-4
BiCMOS Implementation of Cell Signaling for Cell Survival/Death
Jain, S., Naik, P. K., & Bhooshan, S. V. (2010) · International Conference on Signal Acquisition and Processing · doi:10.1109/icsap.2010.36
“This work examines signaling networks that control the survival decision treated with combinations of three primary signals [2, 3] the pro death cytokine, tumor necrosis factor-α (TNF) [4, 5], and the pro survival growth factors, epidermal growth factor (EGF) [6, 7] and insulin [8, 9, 10].”
BackgroundTranscriptional activity of PPARγ in primary human adipocytes
Sauma, L. (2009) · DiVA (Linkoping University)
Pubertas tarda bei der Frau: Ätiologie, Pathogenese, Diagnostik und Therapie
Mattle, V., Seeber, B., Zervomanolakis, I., Grubinger, E., Wildt, L., & Einleitung, Ñ. (2009) · Journal für Klinische Endokrinologie und Stoffwechsel
Molecular dissection of pathways regulating glucose and lipid metabolism using siRNA
Rune, A. (2009) · Figshare
Fiber Treating Metabolic Syndrome
Stamatikos, W. J. B. A. D. (2013) · Journal of Metabolic Syndrome · doi:10.4172/2167-0943.1000130
“Consequently, constant long-term hyperinsulinemia intensifies IR and plays a direct role in the development of T2DM [45,46].”
BackgroundHäring, H.-U. (2009)
triggered by the insulin-signaling pathway
Yamamoto, A., Cremona, M. L., & Rothman, J. E. (2006)
Felice, F. G. D., & Ferreira, S. T. (2014)
INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3
Ahlsén, M. (2007)
Direct Insulin Signaling of Neurons Reverses Diabetic
Brussee, N., Cunningham, F., & Zochodne, D. W. (2004)
Understanding The Regulation Of Adipogenesis And Adipocyte Metabolism In Obesity
Zhao, M. (2015) · University of Minnesota Digital Conservancy (University of Minnesota)
Dresseno, L. P. (2012) · Americanae (AECID Library)
Posey, K. A. (2009) · Europe PMC (PubMed Central)
Role of insulin receptor substrate 1 in energy homeostasis in vivo
Stöhr, O. (2012) · Kölner Universitäts PublikationsServer (Universität zu Köln)
Vu, B. G., Schlievert, P. M., Squier, C. A., Yahr, T. L., Horswill, A. R., & Apicella, M. A. (2014) · doi:10.17077/etd.y6n7p4ee
“Together with the proinflammatory signals from the recruited immune cells, endotoxin (LPS) in the circulation (perhaps spilling over from the intestinal microbiota) can further enhance and maintain the ongoing systemic inflammation in the body [7][10]; chronic systemic inflammation has been previously shown to have an…”
BackgroundIRS-1 and SOCS2 are key regulators of insulin-like growth factor signaling in intestinal cancer
Ramocki, N. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/3cjy-a678
Shin, E. J., Kim, J.-E., Kim, J., Park, Y. M., Yoon, S. K., Jang, B., Lee, S., & Kim, B.-C. (2016) · Journal of Life Science · doi:10.5352/jls.2016.26.3.325
“추출한 RNA 2 μg는 High Capacity RNA-to-cDNA reverse transcriptase Kit를 이용하여 매뉴얼에 따라 cDNA를 합성하 였고 세포 내 포도당 수송에 특이적인 GLUT4 mRNA 발현량 을 측정하기 위해 합성된 cDNA로 RT-PCR을 수행하였다. mRNA 발현은 5‘-CTGTAACTTCATTGTCGGCATGG-3', 5’ -AGGCAGCTGAGATCTGGTCAAAC-3' GLUT4 primer와 5'-GTATGATCCACTCACGGCA-3', 5'-GGTCTCGCTCCTGGAAGAGG-3' GAPDG primer에 100 μ…”
InfluentialComparison of genes of JAK-STAT and PI3K-AKT cycles between cattle and pig in mammary gland
Rastgoo, S., & Nasab, M. P. E. (2014) · DergiPark (Istanbul University)
Effects of insulin gene dosage on body weight and glucose homeostasis
Mehran, A. E. (2015) · cIRcle (University of British Columbia) · doi:10.14288/1.0167270
Ramsay, L. F. (2012) · Summit (Simon Fraser University)
Ide, J. C. (2011) · Library and Archives Canada (Government of Canada) · doi:10.20381/ruor-4408
Aging, Nutrients, and Endogenous Stem Cell Populations
Zuba‐Surma, E. K., Elias, H. K., & Dawn, B. (2013) · CRC Press eBooks · doi:10.1201/b14663-12
Angelini, F., Orlandi, C., Fiore, P. D., Gatteschi, L., Guerra, M., Marzatico, F., Rapetti, M., & Speciani, A. F. (2010) · Basic and clinical dermatology · doi:10.3109/9781439802724.008
Principles and Mechanisms of Morphogenesis and Dysmorphogenesis
Schoenwolf, G. C., Bleyl, S. B., Brauer, P. R., & Francis‐West, P. H. (2009) · Elsevier eBooks · doi:10.1016/b978-0-443-06811-9.10005-3
Lanner, J. T., & Westerblad, H. (2012) · Science Publishers eBooks · doi:10.1201/b11775-8
Pancreatic b Cells in Metabolic Syndrome 30
Hiriart, M., Velasco, M., Díaz‐García, C. M., Larqué, C., & Toledo, A. (2015)
The Impact of Inflammation on the Determinants of Skeletal Muscle Glucose Uptake
Mulligan, K. X. (2012)
A signaling pathway and model for cell death/survival using VHDL
Jain, S., Rastogi, S., Chaudhry, A., & Tiwari, S. (2009) · International Conference on Methods and Models in Computer Science (ICM2CS) · doi:10.1109/icm2cs.2009.5397978
“This work examines signaling networks that control the survival decision treated with combinations of three primary signals [2, 3] the pro death cytokine, tumor necrosis factor-α (TNF) [4, 5], and the pro survival growth factors, epidermal growth factor (EGF) [6, 7] and insulin [8, 9, 10].”
BackgroundStress-activated MIG6 compromises hepatic metabolism during diet-induced obesity
Lutkewitte, A. J. (2016) · IUScholarWorks (Indiana University) · doi:10.7912/c2w59n
Spatio-Temporal Control of Cellular and Organismal Physiology by Sirtuins
Deota, S., Shukla, N., & Kolthur‐Seetharam, U. (2017) · Journal of the Indian Institute of Science · doi:10.1007/s41745-016-0018-9
Wong, B. C. (2015) · TSpace (University of Toronto)
Receptor Tyrosine Kinases and the Insulin Signaling System
White, M. F. (2017) · Endocrinology · doi:10.1007/978-3-319-27318-1_7-1
Vitamin D in Dry Eye and Myopia
Yang, C. H. (2017) · Queensland University of Technology · doi:10.5204/thesis.eprints.113952
Extra-Virgin Olive Oil and Type 2 Diabetes Mellitus
Capurso, A., Crepaldi, G., & Capurso, C. A. (2018) · Practical issues in geriatrics · doi:10.1007/978-3-319-78084-9_4
Non-Immune Islet beta cell susceptibility to failure in NODk mice
Hussain, A. H. (2017) · ANU Open Research (Australian National University) · doi:10.25911/5d67b4a4d618c
“Ghrelin stimulates hunger and feeding behaviour (White, 2003).”
Kadoguchi, T., Shimada, K., Kunimoto, M., & Daida, H. (2018) · Juntendō Igaku/Juntendo igaku · doi:10.14789/jmj.2018.64.jmj18-p410
Insulin resistance and obesity
Farooqui, A. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819603-8.00001-8
Effect of Inflammation on Ketoisocaproic Acid Induced Insulin Resistance In Skeletal Muscle Cells
Mann, G. S. (2018) · YorkSpace (York University)
The Relationship Between the Insulin Receptor Substrates and Metabolic Disease
White, M. F. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-116-5_14
Park, S., & Kim, S. (2021) · Korean Journal of Food Preservation · doi:10.11002/kjfp.2021.28.7.980
“3T3-L1세포 내 IRS, GLUT4 발현에 미치는 영향 IRS는 인슐린 신호전달의 중요한 매개체로 인슐린수용체 가 IRS 단백질의 tyrosine 잔기들을 인산화시킴으로써 신호전 달이 진행된다(White, 2003).”
Mirmira, R. G. (2007) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1091891.545216
Qi, Y., Guo, X., & Guo, S. (2015) · Springer eBooks · doi:10.1007/978-3-319-12125-3_28-2
Immunonanosystems to CNS Pathologies
Tosi, G., Ruozi, B., Badiali, L., Bondioli, L., Belletti, D., Forni, F., & Vandelli, M. A. (2012) · Pan Stanford Publishing eBooks · doi:10.1201/b13159-4
Biochemical bases of endocrinology (II) hormones and other chemical intermediates
Blanco, A., & Blanco, G. V. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91599-1.00016-x
Offermanns, S. (2012) · Springer-Lehrbuch · doi:10.1007/978-3-642-12354-2_54
Müller, G. A. (2015) · Springer eBooks · doi:10.1007/978-3-642-27728-3_157-1
Resistencia a insulina e função da celula 'beta'
Marin, D. M. (2007) · doi:10.47749/t/unicamp.2007.428281
Zhang, Y. (2014) · Springer eBooks · doi:10.1007/978-3-642-27841-9_7109-6
BCL2 Family Genes Expression in Gynecological Diseases
Lasorella, S. (2019) · Journal of Gynecology and Womens Health · doi:10.19080/jgwh.2019.15.555925
Offermanns, S. (2016) · Springer-Lehrbuch · doi:10.1007/978-3-662-46689-6_54
(2007) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2007.08.026
The Liver and Insulin Resistance: The Important Convergence of Endocrinology and Hepatology
Chang, C., Whitt, K. N., Liu, Z., & Caldwell, S. H. (2019) · Contemporary Endocrinology · doi:10.1007/978-3-030-25057-7_13
Zhang, Y. (2017) · Springer eBooks · doi:10.1007/978-3-662-46875-3_7109
The relations between neural insulin signaling and metabolic and neural dysfunctions
Taguchi, A. (2019) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.56.234
Hughes, K., & Reynolds, R. M. (2009) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1158005.619631
Jaroß, W. (2022) · SCIREA journal of biology. · doi:10.54647/biology18231
Molecular Basis of Role of Insulin Resistance in Pathophysiology of Alzheimer’s Disease
Gupta, A. (2022) · International Journal of Health Sciences and Pharmacy · doi:10.47992/ijhsp.2581.6411.0094
An update on the role of antihyperglycemic agents in diabetoporosis
Sharma, N., & Nayak, A. K. (2023) · Journal of Diabetology · doi:10.4103/jod.jod_35_23
Hentu, D. S. R. M., Muchlisin, M. A., Jamil, A. S., Astuti, E. J., & Rafikayanti, A. (2024) · Pharma xplore Jurnal Sains dan Ilmu Farmasi · doi:10.36805/jpx.v9i1.6964
Metadata
- Authors
- White, M. F.
- Affiliations
- Joslin Diabetes Center (US)
- Corresponding author
- White, Morris F.
- ORCID
- White, Morris F.
- Venue
- Science
- Published
- 2003-12-05
- Volume
- 302
- Issue
- 5651
- Pages
- 1710-1711
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2115177689
- Cited by
- 733
- References
- 19
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 13 · 2023: 21 · 2022: 24 · 2021: 35 · 2020: 32 · 2019: 30 · 2018: 36 · 2017: 35 · 2016: 39 · 2015: 47 · 2014: 35 · 2013: 39 · 2012: 50
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- insulin signaling, insulin resistance, obesity, type 2 diabetes, pancreatic beta-cell failure, chronic inflammation, insulin receptor substrate 2
- MeSH terms
- Animals, Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Inflammation, Insulin, Insulin Resistance, Islets of Langerhans, Models, Biological, Obesity, Phosphoproteins, Phosphorylation, Receptor, Insulin, Somatomedins, Signal Transduction, Cytokines, Intracellular Signaling Peptides and Proteins, Mice, Insulin Receptor Substrate Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
