The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Functional Stoichiometry and Local Enrichment of Calmodulin Interacting with Ca 2+ Channels
Abstract
Calmodulin (CaM) interactions with Ca 2+ channels mediate both Ca 2+ regulation of channels and local Ca 2+ triggering of transcription factors implicated in neuronal memory. Crucial to these functions are the number of CaM molecules (CaMs) regulating each channel, and the number of CaMs privy to the local Ca 2+ signal from each channel. To resolve these parameters, we fused L-type Ca 2+ channels to single CaM molecules. These chimeric molecules revealed that a single CaM directs L-type channel regulation. Similar fusion molecules were used to estimate the local CaM concentration near Ca 2+ channels. This estimate indicates marked enrichment of local CaM, as if a “school” of nearby CaMs were poised to enhance the transduction of local Ca 2+ entry into diverse signaling pathways.
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Deisseroth, K., Bito, H., & Tsien, R. W. (1996) · Neuron · doi:10.1016/s0896-6273(00)80026-4 · Cited by 698
Calmodulin Is a Limiting Factor in the Cell
Persechini, A. (2002) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(01)00144-x · Cited by 148
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Metadata
- Authors
- Mori, M. X., Erickson, M. G., & Yue, D. T.
- Venue
- Science
- Published
- 2004-04-16
- Volume
- 304
- Issue
- 5669
- Pages
- 432-435
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1995946312
- Cited by
- 193
- References
- 2
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mori, M. X., Erickson, M. G., & Yue, D. T. (2004). Functional Stoichiometry and Local Enrichment of Calmodulin Interacting with Ca 2+ Channels. Science. https://doi.org/10.1126/science.1093490
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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