Calmodulin Is a Limiting Factor in the Cell

Persechini, A

doi:10.1016/s1050-1738(01)00144-x

Cited by 148Protein Kinase Regulation and GTPase SignalingSignaling Pathways in DiseaseS100 Proteins and Annexins

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Calmodulin Is a Limiting Factor in the Cell

Persechini, A·2002·Trends in Cardiovascular Medicine

DOI 10.1016/s1050-1738(01)00144-x

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Abstract

The total intracellular concentration of calmodulin (CaM) in the cell appears to be significantly below the total concentration of its targets, making it a limiting factor in their regulation. In this review we discuss the ways in which this is likely to impact signaling. A key conclusion is that competition for a limiting pool of CaM enables cross-talk between CaM-dependent signaling pathways.

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Activation of CaMKII is curtailed by insufficient cellular free CaM and by the relatively low affinity of unphosphorylated CaMKII for free Ca2+/CaM.
“Activation is also curtailed by insufficient cellular free CaM for all its binding proteins, since a significant fraction of CaM is membrane bound and not available in the cytosol, and the relatively low affinity of unphosphorylated CaMKII for the free Ca2+/CaM (95).”
From Synaptic memory and CaMKII (2023) · cites this paper as [95]

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“Activation is also curtailed by insuf ﬁ cient cellular free CaM for all its binding proteins, since a signi ﬁ cant fraction of CaM is membrane bound and not available in the cytosol, and the relatively low af ﬁ nity of unphosphorylated CaMKII for the free Ca 2 1 /CaM (95).”
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Self-citation

Authors: Persechini, A.
Affiliations: University of Missouri–Kansas City (US)
Corresponding author: Persechini, A
ORCID: Persechini, A
Venue: Trends in Cardiovascular Medicine
Publisher: Elsevier BV
Published: 2002-01
Volume: 12
Issue: 1
Pages: 32-37
ISSN: 1050-1738 (ISSN-L)
DOI: 10.1016/s1050-1738(01)00144-x
OpenAlex: W1976471735
Cited by: 148
References: 40
Citations by year: 2026: 2 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 3 · 2012: 2
FWCI: 3.48
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Cardiovascular Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01dk053863-04)
National Institute of Diabetes and Digestive and Kidney Diseases (DK53863)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
Keywords: calmodulin, intracellular calcium signaling, signaling crosstalk, calcium-dependent signaling
MeSH terms: Calcium, Calmodulin, Humans, Protein Binding, Protein Processing, Post-Translational, Biosensing Techniques, Signal Transduction

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Calmodulin Is a Limiting Factor in the Cell

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