Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity

Deisseroth, Karl; Bito, Haruhiko; Tsien, Richard W

doi:10.1016/s0896-6273(00)80026-4

Cited by 698Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsSignaling Pathways in Disease

Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity

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Deisseroth, Karl, Bito, Haruhiko, Tsien, Richard W·1996·Neuron

DOI 10.1016/s0896-6273(00)80026-4

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Abstract

Phosphorylation of the transcription factor CREB is thought to be important in processes underlying long-term memory. It is unclear whether CREB phosphorylation can carry information about the sign of changes in synaptic strength, whether CREB pathways are equally activated in neurons receiving or providing synaptic input, or how synapse-to-nucleus communication is mediated. We found that Ca(2+)-dependent nuclear CREB phosphorylation was rapidly evoked by synaptic stimuli including, but not limited to, those that induced potentiation and depression of synaptic strength. In striking contrast, high frequency action potential firing alone failed to trigger CREB phosphorylation. Activation of a submembranous Ca2+ sensor, just beneath sites of Ca2+ entry, appears critical for triggering nuclear CREB phosphorylation via calmodulin and a Ca2+/calmodulin-dependent protein kinase.

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The Ca2+ rise relevant for nuclear signaling must occur within 1-2 μm of the channel mouth, but is connected to the nucleus by a signaling pathway.
“The Ca2+ rise that matters for signaling to the nucleus must occur within 1-2 μm of the channel mouth (Deisseroth et al., 1996), but is linked to the nucleus by a signaling pathway (Ma et al., 2014), depicted in Fig. 4.”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Deisseroth et al., 1996

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Authors: Deisseroth, K., Bito, H., & Tsien, R. W.
Affiliations: Stanford Medicine (US)
Corresponding author: Tsien, Richard W
ORCID: Deisseroth, Karl
Bito, Haruhiko
Tsien, Richard W
Venue: Neuron
Publisher: Elsevier BV
Published: 1996-01
Volume: 16
Issue: 1
Pages: 89-101
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(00)80026-4
OpenAlex: W2025247587
Cited by: 698
References: 84
Citations by year: 2026: 4 · 2025: 10 · 2024: 22 · 2023: 13 · 2022: 12 · 2021: 16 · 2020: 7 · 2019: 15 · 2018: 22 · 2017: 15 · 2016: 22 · 2015: 18 · 2014: 18 · 2013: 18 · 2012: 21
FWCI: 18.90
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 2292 d)
Locations: Neuron (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: CREB phosphorylation, hippocampal synaptic plasticity, long-term memory, synaptic potentiation, synaptic depression, calmodulin, calcium/calmodulin-dependent protein kinase, action potential firing
MeSH terms: Action Potentials, Animals, Calcium, Calmodulin, Cell Compartmentation, Cell Nucleus, Cells, Cultured, Chelating Agents, Egtazic Acid, Hippocampus, Nerve Tissue Proteins, Synaptic Transmission, Phosphorylation, Protein Processing, Post-Translational, Recombinant Proteins, Synapses, Signal Transduction, Rats, Sprague-Dawley, Cyclic AMP Response Element-Binding Protein, Long-Term Potentiation, Calcium-Calmodulin-Dependent Protein Kinases, Rats

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Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity

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