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The Semaphorin 4D Receptor Plexin-B1 Is a GTPase Activating Protein for R-Ras
Abstract
Plexins are cell surface receptors for semaphorin molecules, and their interaction governs cell adhesion and migration in a variety of tissues. We report that the Semaphorin 4D (Sema4D) receptor Plexin-B1 directly stimulates the intrinsic guanosine triphosphatase (GTPase) activity of R-Ras, a member of the Ras superfamily of small GTP-binding proteins that has been implicated in promoting cell adhesion and neurite outgrowth. This activity required the interaction of Plexin-B1 with Rnd1, a small GTP-binding protein of the Rho family. Down-regulation of R-Ras activity by the Plexin-B1-Rnd1 complex was essential for the Sema4D-induced growth cone collapse in hippocampal neurons. Thus, Plexin-B1 mediates Sema4D-induced repulsive axon guidance signaling by acting as a GTPase activating protein for R-Ras.
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Cites
GTPase-activating proteins: Helping hands to complement an active site
Scheffzek, K., Ahmadian, M. R., & Wittinghofer, A. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01224-9 · Cited by 410
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Negishi-Koga, T., Shinohara, M., Komatsu, N., Bito, H., Kodama, T., Friedel, R. H., & Takayanagi, H. (2011) · Nature Medicine · doi:10.1038/nm.2489 · Cited by 498
Intracellular signalling controlling integrin activation in lymphocytes
Kinashi, T. (2005) · Nature Reviews Immunology · doi:10.1038/nri1646 · Cited by 477
Rho and Ras GTPases in axon growth, guidance, and branching
Hall, A., & Lalli, G. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001818 · Cited by 437
Semaphorins and their Signaling Mechanisms
Alto, L. T., & Terman, J. R. (2017) · Methods in Molecular Biology · doi:10.1007/978-1-4939-6448-2_1 · Cited by 429
Semaphorins and their receptors in immune cell interactions
Suzuki, K., Kumanogoh, A., & Kikutani, H. (2008) · Nature Immunology · doi:10.1038/ni1553 · Cited by 400
Metadata
- Authors
- Oinuma, I., Ishikawa, Y., Katoh, H., & Negishi, M.
- Venue
- Science
- Published
- 2004-08-06
- Volume
- 305
- Issue
- 5685
- Pages
- 862-865
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965206733
- Cited by
- 384
- References
- 1
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Oinuma, I., Ishikawa, Y., Katoh, H., & Negishi, M. (2004). The Semaphorin 4D Receptor Plexin-B1 Is a GTPase Activating Protein for R-Ras. Science. https://doi.org/10.1126/science.1097545
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
