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Functional Adaptation of BabA, the H. pylori ABO Blood Group Antigen Binding Adhesin
Abstract
Adherence by Helicobacter pylori increases the risk of gastric disease. Here, we report that more than 95% of strains that bind fucosylated blood group antigen bind A, B, and O antigens (generalists), whereas 60% of adherent South American Amerindian strains bind blood group O antigens best (specialists). This specialization coincides with the unique predominance of blood group O in these Amerindians. Strains differed about 1500-fold in binding affinities, and diversifying selection was evident in babA sequences. We propose that cycles of selection for increased and decreased bacterial adherence contribute to babA diversity and that these cycles have led to gradual replacement of generalist binding by specialist binding in blood group O–dominant human populations.
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Cited by
Pathogenesis of Helicobacter pylori Infection
Kusters, J. G., van Vliet, A. H. M., & Kuipers, E. J. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00054-05 · Cited by 2,526
Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk
Wroblewski, L. E., Peek, R. M., & Wilson, K. T. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00011-10 · Cited by 1,442
Mucin dynamics and enteric pathogens
McGuckin, M. A., Lindén, S. K., Sutton, P., & Florin, T. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2538 · Cited by 1,428
Self-citationMucins in the mucosal barrier to infection
Linden, S. K., Sutton, P., Karlsson, N. G., Korolik, V, & McGuckin, M. A. (2008) · Mucosal Immunology · doi:10.1038/mi.2008.5 · Cited by 1,234
Self-citationThe human gut microbiome: ecology and recent evolutionary changes
Walter, J., & Ley, R. (2011) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090110-102830 · Cited by 720
Metadata
- Authors
- Aspholm-Hurtig, M., Dailide, G., Lahmann, M., Kalia, A., Ilver, D., Roche, N., Vikström, S., Sjöström, R., Lindén, S., Bäckström, A., Lundberg, C., Arnqvist, A., Mahdavi, J., Nilsson, U. J., Velapatiño, B., Gilman, R. H., Gerhard, M., Alarcon, T., López-Brea, M., Nakazawa, T., Fox, J. G., Correa, P., Dominguez-Bello, M. G., Perez-Perez, G. I., Blaser, M. J., Normark, S., Carlstedt, I., Oscarson, S., Teneberg, S., Berg, D. E., & Borén, T.
- Venue
- Science
- Published
- 2004-07-23
- Volume
- 305
- Issue
- 5683
- Pages
- 519-522
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2098788436
- Cited by
- 415
- References
- 0
- FWCI
- 29.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Aspholm-Hurtig, M., Dailide, G., Lahmann, M., Kalia, A., Ilver, D., Roche, N., Vikström, S., Sjöström, R., Lindén, S., Bäckström, A., Lundberg, C., Arnqvist, A., Mahdavi, J., Nilsson, U. J., Velapatiño, B., Gilman, R. H., Gerhard, M., Alarcon, T., López-Brea, M., . . . Borén, T. (2004). Functional Adaptation of BabA, the H. pylori ABO Blood Group Antigen Binding Adhesin. Science. https://doi.org/10.1126/science.1098801
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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