The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
RNAi-Independent Heterochromatin Nucleation by the Stress-Activated ATF/CREB Family Proteins
Abstract
At the silent mating-type interval of fission yeast, the RNA interference (RNAi) machinery cooperates with cenH , a DNA element homologous to centromeric repeats, to initiate heterochromatin formation. However, in RNAi mutants, heterochromatin assembly can still occur at low efficiency. Here, we report that Atf1 and Pcr1, two ATF/CREB family proteins, act in a parallel mechanism to the RNAi pathway for heterochromatin nucleation. Deletion of atf1 or pcr1 alone has little effect on silencing at the mating-type region, but when combined with RNAi mutants, double mutants fail to nucleate heterochromatin assembly. Moreover, deletion of atf1 or pcr1 in combination with cenH deletion causes loss of silencing and heterochromatin formation. Furthermore, Atf1 and Pcr1 bind to the mating-type region and target histone H3 lysine-9 methylation and the Swi6 protein essential for heterochromatin assembly. These analyses link ATF/CREB family proteins, involved in cellular response to environmental stresses, to nucleation of constitutive heterochromatin.
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Self-citationRb targets histone H3 methylation and HP1 to promoters
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Establishment and Maintenance of a Heterochromatin Domain
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Self-citationARGONAUTE4 Control of Locus-Specific siRNA Accumulation and DNA and Histone Methylation
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Heterochromatic Silencing and HP1 Localization in Drosophila Are Dependent on the RNAi Machinery
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Epigenetics and the environment: emerging patterns and implications
Feil, R., & Fraga, M. F. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3142 · Cited by 1,929
Grewal, S. I. S., & Jia, S. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2008 · Cited by 1,263
Self-citationCharacterization of Dicer-deficient murine embryonic stem cells
Murchison, E. P., Partridge, J. F., Tam, O. H., Cheloufi, S., & Hannon, G. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505479102 · Cited by 800
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Metadata
- Authors
- Jia, S., Noma, K.-I., & Grewal, S. I. S.
- Venue
- Science
- Published
- 2004-06-25
- Volume
- 304
- Issue
- 5679
- Pages
- 1971-1976
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1989753542
- Cited by
- 324
- References
- 23
- FWCI
- 8.97
- Type
- journal article
- Language
- en
- Open access
- closed
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