The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Enhanced Dendritic Cell Antigen Capture via Toll-Like Receptor-Induced Actin Remodeling
Abstract
Microbial products are sensed through Toll-like receptors (TLRs) and trigger a program of dendritic cell (DC) maturation that enables DCs to activate T cells. Although an accepted hallmark of this response is eventual down-regulation of DC endocytic capacity, we show that TLR ligands first acutely stimulate antigen macropinocytosis, leading to enhanced presentation on class I and class II major histocompatibility complex molecules. Simultaneously, actin-rich podosomes disappear, which suggests a coordinated redeployment of actin to fuel endocytosis. These reciprocal changes are transient and require p38 and extracellular signal–regulated kinase activation. Thus, the DC actin cytoskeleton can be rapidly mobilized in response to innate immune stimuli to enhance antigen capture and presentation.
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Cites
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
The Danger Model: A Renewed Sense of Self
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Antigen Presentation and T Cell Stimulation by Dendritic Cells
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Cited by
Apetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A., Mignot, G., Maiuri, M. C., Ullrich, E., Saulnier, P., et al. (2007) · Nature Medicine · doi:10.1038/nm1622 · Cited by 3,056
Inflammatory bowel disease: cause and immunobiology
Baumgart, D. C., & Carding, S. R. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60750-8 · Cited by 2,147
The ins and outs of MHC class II-mediated antigen processing and presentation
Roche, P. A., & Furuta, K. (2015) · Nature reviews. Immunology · doi:10.1038/nri3818 · Cited by 1,207
Takahashi, K., Rochford, C. D. P., & Neumann, H. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041611 · Cited by 1,124
CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4
Zanoni, I., Ostuni, R., Marek, L. R., Barresi, S., Barbalat, R., Barton, G. M., Granucci, F., & Kagan, J. C. (2011) · Cell · doi:10.1016/j.cell.2011.09.051 · Cited by 997
Metadata
- Authors
- West, M. A., Wallin, R. P. A., Matthews, S. P., Svensson, H. G., Zaru, R., Ljunggren, H.-G., Prescott, A. R., & Watts, C.
- Venue
- Science
- Published
- 2004-08-20
- Volume
- 305
- Issue
- 5687
- Pages
- 1153-1157
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979680810
- Cited by
- 522
- References
- 30
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- West, M. A., Wallin, R. P. A., Matthews, S. P., Svensson, H. G., Zaru, R., Ljunggren, H.-G., Prescott, A. R., & Watts, C. (2004). Enhanced Dendritic Cell Antigen Capture via Toll-Like Receptor-Induced Actin Remodeling. Science. https://doi.org/10.1126/science.1099153
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
