The ins and outs of MHC class II-mediated antigen processing and presentation

Immunobiology of Dendritic Cells

Banchereau, J., Brière, F., Caux, C., Davoust, J. M., Lebecque, S., Liu, Y., Pulendran, B., & Palucka, K. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.767 · Cited by 6,612 · see citing works

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

Sallusto, F., Cella, M., Danieli, C., & Lanzavecchia, A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.2.389 · Cited by 2,501 · see citing works

Renal and Extrarenal Effects of Gum Arabic (Acacia Senegal) - What Can be Learned from Animal Experiments?

Nasir, O. (2013) · Kidney & Blood Pressure Research · doi:10.1159/000350152 · Cited by 2,331 · see citing works

Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes

Zitvogel, L., Régnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1998) · Nature Medicine · doi:10.1038/nm0598-594 · Cited by 2,266 · see citing works

Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages

Gutierrez, M. G., Master, S. S., Singh, S. B., Taylor, G. A., Colombo, M. I., & Deretic, V. (2004) · Cell · doi:10.1016/j.cell.2004.11.038 · Cited by 2,252 · see citing works

Cross-presentation by dendritic cells

Joffre, O. P., Segura, É., Savina, A., & Amigorena, S. (2012) · Nature reviews. Immunology · doi:10.1038/nri3254 · Cited by 1,646 · see citing works

Pathways of Antigen Processing

Blum, J. S., Wearsch, P. A., & Cresswell, P. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095910 · Cited by 1,561 · see citing works

Endocytosis and the recycling of plasma membrane.

Steinman, R. M., Mellman, I., Müller, W. A., & Cohn, Z. A. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.1.1 · Cited by 1,453 · see citing works

CELL BIOLOGY OF ANTIGEN PROCESSING IN VITRO AND IN VIVO

Trombetta, E. S., & Mellman, I. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104538 · Cited by 1,173 · see citing works

The Induction of Tolerance by Dendritic Cells That Have Captured Apoptotic Cells

Steinman, R. M., Turley, S. J., Mellman, I., & Inaba, K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.411 · Cited by 1,172 · see citing works

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

Cella, M., Engering, A. J., Pinet, V., Pieters, J., & Lanzavecchia, A. (1997) · Nature · doi:10.1038/42030 · Cited by 1,123 · see citing works

Regulation of Phagosome Maturation by Signals from Toll-Like Receptors

Blander, J. M., & Medzhitov, R. (2004) · Science · doi:10.1126/science.1096158 · Cited by 991 · see citing works

Indirect activation of naïve CD4+ T cells by dendritic cell–derived exosomes

Théry, C., Duban, L., Segura, É., Véron, P., Lantz, O. J., & Amigorena, S. (2002) · Nature Immunology · doi:10.1038/ni854 · Cited by 961 · see citing works

In Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination

Bonifaz, L. C., Bonnyay, D., Charalambous, A., Darguste, D. I., Fujii, S., Soares, H., Brimnes, M. K., Moltedo, B., Moran, T. M., & Steinman, R. M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20032220 · Cited by 921 · see citing works

Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA

Steimle, V., Siegrist, C.-A., Mottet, A., Lisowska-Grospierre, B., & Mach, B. (1994) · Science · doi:10.1126/science.8016643 · Cited by 898 · see citing works

Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy

Paludan, C., Schmid, D., Landthaler, M., Vockerodt, M., Kube, D., Tuschl, T., & Münz, C. (2005) · Science · doi:10.1126/science.1104904 · Cited by 860 · see citing works

Toll-dependent selection of microbial antigens for presentation by dendritic cells

Blander, J. M., & Medzhitov, R. M. (2006) · Nature · doi:10.1038/nature04596 · Cited by 841 · see citing works

Viral Subversion of the Immune System

Tortorella, D., Gewurz, B. E., Furman, M. H., Schust, D. J., & Ploegh, H. L. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.861 · Cited by 828 · see citing works

Virus entry by macropinocytosis

Mercer, J., & Helenius, A. (2009) · Nature Cell Biology · doi:10.1038/ncb0509-510 · Cited by 814 · see citing works

Differential Lysosomal Proteolysis in Antigen-Presenting Cells Determines Antigen Fate

Delamarre, L., Pack, M., Chang, H. C., Mellman, I., & Trombetta, E. S. (2005) · Science · doi:10.1126/science.1108003 · Cited by 776 · see citing works

ER–phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells

Guermonprez, P., Saveanu, L., Kleijmeer, M. J., Davoust, J. M., Endert, P. V., & Amigorena, S. (2003) · Nature · doi:10.1038/nature01911 · Cited by 753 · see citing works

Developmental regulation of MHC class II transport in mouse dendritic cells

Pierre, P., Turley, S. J., Gatti, E., Hull, M. J., Meltzer, J., Mirza, A., Inaba, K., Steinman, R. M., & Mellman, I. (1997) · Nature · doi:10.1038/42039 · Cited by 746 · see citing works

Activation of Lysosomal Function During Dendritic Cell Maturation

Trombetta, E. S., Ebersold, M. W., Garrett, W. S., Pypaert, M., & Mellman, I. (2003) · Science · doi:10.1126/science.1080106 · Cited by 740 · see citing works

Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes.

Schmid, D., Pypaert, M., & Münz, C. (2007) · Immunity · doi:10.1016/j.immuni.2006.10.018 · Cited by 732 · see citing works

Macropinocytosis: an endocytic pathway for internalising large gulps

Lim, J. P., & Gleeson, P. A. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2011.20 · Cited by 705 · see citing works

Phagosomes are competent organelles for antigen cross-presentation

Houde, M., Bertholet, S., Gagnon, É., Brunet, S., Goyette, G., Laplante, A., Princiotta, M. F., Thibault, P., Sacks, D. L., & Desjardins, M. (2003) · Nature · doi:10.1038/nature01912 · Cited by 700 · see citing works

Phagocytosis

Stuart, L. M., & Ezekowitz, R. A. B. (2005) · Immunity · doi:10.1016/j.immuni.2005.05.002 · Cited by 667 · see citing works

ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming

Segura, É., Nicco, C., Lombard, B., Véron, P., Raposo, G., Batteux, F., Amigorena, S., & Théry, C. (2005) · Blood · doi:10.1182/blood-2005-01-0220 · Cited by 614 · see citing works

A Coat Protein on Phagosomes Involved in the Intracellular Survival of Mycobacteria

Ferrari, G., Langen, H., Naito, M., & Pieters, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80754-0 · Cited by 579 · see citing works

Antigen-presentation properties of plasmacytoid dendritic cells.

Villadangos, J., & Young, L. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.09.002 · Cited by 577 · see citing works

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

Nedjic, J., Aichinger, M., Emmerich, J., Mizushima, N., & Klein, L. (2008) · Nature · doi:10.1038/nature07208 · Cited by 533 · see citing works

Regulation of B Lymphocyte Responses to Foreign and Self-Antigens by the CD19/CD21 Complex

Fearon, D. T., Carroll, M. C., & Carroll, M. C. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.393 · Cited by 529 · see citing works

Cathepsin S Required for Normal MHC Class II Peptide Loading and Germinal Center Development

Shi, G., Villadangos, J. A., Dranoff, G., Small, C. G., Gu, L., Haley, K. J., Riese, R. J., Ploegh, H. L., & Chapman, H. A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80020-5 · Cited by 524 · see citing works

Enhanced Dendritic Cell Antigen Capture via Toll-Like Receptor-Induced Actin Remodeling

West, M. A., Wallin, R. P. A., Matthews, S. P., Svensson, H. G., Zaru, R., Ljunggren, H., Prescott, A. R., & Watts, C. K. W. (2004) · Science · doi:10.1126/science.1099153 · Cited by 521 · see citing works

In vivo requirement for Atg5 in antigen presentation by dendritic cells

Lee, H. K., Mattei, L. M., Steinberg, B. E., Alberts, P., Lee, Y. H., Chervonsky, A., Mizushima, N., Grinstein, S., & Iwasaki, A. (2010) · Immunity · doi:10.1016/j.immuni.2009.12.006 · Cited by 506 · see citing works

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

Roche, P. A., & Cresswell, P. (1990) · Nature · doi:10.1038/345615a0 · Cited by 494 · see citing works

Transport of Peptide-MHC Class II Complexes in Developing Dendritic Cells

Turley, S. J., Inaba, K., Garrett, W. S., Ebersold, M. W., Unternaehrer, J., Steinman, R. M., & Mellman, I. (2000) · Science · doi:10.1126/science.288.5465.522 · Cited by 477 · see citing works

Phagocytosis of antigens by Langerhans cells in vitro.

Sousa, C. R. E., Stahl, P. D., & Austyn, J. M. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.2.509 · Cited by 470 · see citing works

Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis

Wegner, N., Lundberg, K., Kinloch, A., Fisher, B. A., Malmström, V., Feldmann, M., & Venables, P. J. (2009) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00850.x · Cited by 470 · see citing works

Regulation of MHC class II gene expression by the class II transactivator

Reith, W., LeibundGut‐Landmann, S., & Waldburger, J. (2005) · Nature reviews. Immunology · doi:10.1038/nri1708 · Cited by 463 · see citing works

Developmental Control of Endocytosis in Dendritic Cells by Cdc42

Garrett, W. S., Chen, L.-M., Kroschewski, R., Ebersold, M. W., Turley, S. J., Trombetta, S., Galán, J. E., & Mellman, I. (2000) · Cell · doi:10.1016/s0092-8674(00)00038-6 · Cited by 452 · see citing works

Follicular Dendritic Cells Carry MHC Class II-Expressing Microvesicles at Their Surface

Denzer, K., van Eijk, M., Kleijmeer, M. J., Jakobson, E., de Groot, C. H., & Geuze, H. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1259 · Cited by 451 · see citing works

Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane

Chow, A. Y., Toomre, D. K., Garrett, W. S., & Mellman, I. (2002) · Nature · doi:10.1038/nature01006 · Cited by 448 · see citing works

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

Amigorena, S., Drake, J. R., Webster, P. C., & Mellman, I. (1994) · Nature · doi:10.1038/369113a0 · Cited by 439 · see citing works

MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell‐Induced Exosomes Via Distinct Multivesicular Body Pathways

Buschow, S. I., Hoen, E. N. M. N., van Niel, G., Pols, M. S., ten Broeke, T., Lauwen, M. M., OSSENDORP, F. A., Melief, C. J. M., Raposo, G., Wubbolts, R., et al. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00963.x · Cited by 430 · see citing works

Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors.

Rock, K. L., Benacerraf, B., & Abbas, A. K. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.160.4.1102 · Cited by 420 · see citing works

Impaired Invariant Chain Degradation and Antigen Presentation and Diminished Collagen-Induced Arthritis in Cathepsin S Null Mice

Nakagawa, T. Y., Brissette, W. H., Lira, P. D., Griffiths, R., Petrushova, N., Stock, J. L., McNeish, J. D., Eastman, S., Howard, E. D., Clarke, S. R. M., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80021-7 · Cited by 418 · see citing works

The Formation of Immunogenic Major Histocompatibility Complex Class II–Peptide Ligands in Lysosomal Compartments of Dendritic Cells Is Regulated by Inflammatory Stimuli

Inaba, K., Turley, S. J., Iyoda, T., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.6.927 · Cited by 417 · see citing works

T-cell engagement of dendritic cells rapidly rearranges MHC class II transport

Boes, M. L., Černý, J., Massol, R., den Brouw, M. O., Kirchhausen, T. L., Chen, J., & Ploegh, H. L. (2002) · Nature · doi:10.1038/nature01004 · Cited by 416 · see citing works

Early Events in B Cell Activation

Harwood, N. E., & Batista, F. D. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101216 · Cited by 404 · see citing works

Invariant Chain Structure and MHC Class II Function

Cresswell, P. (1996) · Cell · doi:10.1016/s0092-8674(00)81025-9 · Cited by 380 · see citing works

Dendritic Cell-Derived Exosomes for Cancer Immunotherapy: What's Next?

Viaud, S., Théry, C., Ploix, S., Tursz, T., Lapierre, V., Lantz, O. J., Zitvogel, L., & Chaput, N. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3276 · Cited by 332 · see citing works

Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation

Anderson, H. A., Hiltbold, E. M., & Roche, P. A. (2000) · Nature Immunology · doi:10.1038/77842 · Cited by 326 · see citing works

Downregulation of Major Histocompatibility Complex Class I by Human Ubiquitin Ligases Related to Viral Immune Evasion Proteins

Bartee, E., Mansouri, M., Nerenberg, B. T. H., Gouveia, K., & Früh, K. (2004) · Journal of Virology · doi:10.1128/jvi.78.3.1109-1120.2004 · Cited by 325 · see citing works

Interleukin-10 Down-Regulates MHC Class II αβ Peptide Complexes at the Plasma Membrane of Monocytes by Affecting Arrival and Recycling

Koppelman, B., Neefjes, J., de Vries, J. E., & Malefyt, R. D. W. (1997) · Immunity · doi:10.1016/s1074-7613(00)80404-5 · Cited by 307 · see citing works

The Small GTPase Rac2 Controls Phagosomal Alkalinization and Antigen Crosspresentation Selectively in CD8+ Dendritic Cells

Savina, A., Peres, A., Cebrián, I., Carmo, N., Moita, C. F., Hacohen, N., Moita, L. F., & Amigorena, S. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.013 · Cited by 306 · see citing works

Ubiquitin and Membrane Protein Turnover: From Cradle to Grave

MacGurn, J. A., Hsu, P.-C., & Emr, S. D. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060210-093619 · Cited by 295 · see citing works

Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells

Kleijmeer, M. J., Ramm, G., Schuurhuis, D. H., Griffith, J. M., Rescigno, M., Ricciardi‐Castagnoli, P., Rudensky, A. Y., OSSENDORP, F. A., Melief, C. J. M., Stoorvogel, W., et al. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200103071 · Cited by 288 · see citing works

Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells

Tomazin, R., Boname, J. M., Hegde, N. R., Lewinsohn, D. M., Altschuler, Y., Jones, T. R., Cresswell, P., Nelson, J. A., Riddell, S. R., & Johnson, D. C. (1999) · Nature Medicine · doi:10.1038/12478 · Cited by 278 · see citing works

T cell‐induced secretion of MHC class II–peptide complexes on B cell exosomes

Muntasell, A., Berger, A. C., & Roche, P. A. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601842 · Cited by 278 · see citing works

Mature dendritic cells use endocytic receptors to capture and present antigens

Platt, C. D., Jessica, K., Chalouni, C. M., Ebersold, M. W., Bou-Reslan, H., Carano, R. A. D., Mellman, I., & Delamarre, L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910609107 · Cited by 275 · see citing works

Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination

Shin, J., Ebersold, M. W., Pypaert, M., Delamarre, L., Hartley, A., & Mellman, I. (2006) · Nature · doi:10.1038/nature05261 · Cited by 262 · see citing works

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

Gassart, A. D., Camosseto, V., Thibodeau, J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708874105 · Cited by 259 · see citing works

Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells

Ireland, J. M., & Unanue, E. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110640 · Cited by 249 · see citing works

Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells

Young, L. J., Wilson, N. S., Schnorrer, P., et al. (2008) · Nature Immunology · doi:10.1038/ni.1665 · Cited by 236 · see citing works

CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10–driven MARCH1-mediated ubiquitination and degradation

Tze, L. E., Horikawa, K., Domaschenz, H., Howard, D. R., Roots, C. M., Rigby, R. J., Way, D. A., Ohmura‐Hoshino, M., Ishido, S., Andoniou, C. E., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20092203 · Cited by 229 · see citing works

Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization.

Roche, P. A., Teletski, C. L., Stang, E., Bakke, O., & Long, E. O. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8581 · Cited by 228 · see citing works

Tetraspan microdomains distinct from lipid rafts enrich select peptide–MHC class II complexes

Kropshofer, H., Spindeldreher, S., Röhn, T. A., Platania, N., Grygar, C., Daniel, N., Wolpl, A., Langen, H., Horejsi, V., & Vogt, A. B. (2001) · Nature Immunology · doi:10.1038/ni750 · Cited by 219 · see citing works

Dendritic cells constitutively present self antigens in their immature state in vivo and regulate antigen presentation by controlling the rates of MHC class II synthesis and endocytosis

Wilson, N. S., El-Sukkari, D., & Villadangos, J. A. (2003) · Blood · doi:10.1182/blood-2003-08-2729 · Cited by 212 · see citing works

Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP

Manoury, B., Mazzeo, D., Fugger, L. H., Viner, N. J., Ponsford, M., Streeter, H. B., Mazza, G., Wraith, D. C., & Watts, C. K. W. (2002) · Nature Immunology · doi:10.1038/ni754 · Cited by 211 · see citing works

Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing

Romão, S., Gasser, N., Becker, A. C., Guhl, B., Bajagic, M., Vanoaica, D., Ziegler, U., Roesler, J., Dengjel, J., Reichenbach, J., et al. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201308173 · Cited by 203 · see citing works

Polarized Secretion of Lysosomes at the B Cell Synapse Couples Antigen Extraction to Processing and Presentation

Yuseff, M.-I., Reversat, A., Lankar, D., Diaz, J., Fanget, I., Pierobon, P., Randrian, V., Larochette, N., Vascotto, F., Desdouets, C., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.07.008 · Cited by 202 · see citing works

Dendritic Cells Regulate Exposure of MHC Class II at Their Plasma Membrane by Oligoubiquitination

van Niel, G., Wubbolts, R., ten Broeke, T., Buschow, S. I., OSSENDORP, F. A., Melief, C. J. M., Raposo, G., van Balkom, B. W. M., & Stoorvogel, W. (2006) · Immunity · doi:10.1016/j.immuni.2006.11.001 · Cited by 195 · see citing works

Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments

Castellino, F., & Germain, R. N. (1995) · Immunity · doi:10.1016/1074-7613(95)90080-2 · Cited by 194 · see citing works

Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forces

Villadangos, J., Schnorrer, P., & Wilson, N. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00317.x · Cited by 189 · see citing works

Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells

Chatterjee, B., Smed‐Sörensen, A., Cohn, L. B., Chalouni, C. M., Vandlen, R. A., Lee, B.-C., Widger, J., Keler, T., Delamarre, L., & Mellman, I. (2012) · Blood · doi:10.1182/blood-2012-01-402370 · Cited by 187 · see citing works

CD4 T cell traffic control:in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles

Brocker, T., Gulbranson‐Judge, A., Flynn, S., Riedinger, M., Raykundalia, C., & Lane, P. J. L. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199905)29:05 · Cited by 186 · see citing works

Novel regulation of MHC class II function in B cells

Matsuki, Y., Ohmura‐Hoshino, M., Gotō, E., Aoki, M., Mito-Yoshida, M., Uematsu, M., Hasegawa, T., Koseki, H., Ohara, O., Nakayama, M., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601556 · Cited by 183 · see citing works

MHC class II molecules on the move for successful antigen presentation

Rocha, N., & Neefjes, J. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601945 · Cited by 167 · see citing works

Interleukin‐10‐induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes

Thibodeau, J., Bourgeois‐Daigneault, M., Huppé, G., Tremblay, J., Aumont, A., Houde, M., Bartee, E., Brunet, A., Gauvreau, M., Gassart, A. D., et al. (2008) · European Journal of Immunology · doi:10.1002/eji.200737902 · Cited by 166 · see citing works

Class II MHC molecules are present in macrophage lysosomes and phagolysosomes that function in the phagocytic processing of Listeria monocytogenes for presentation to T cells.

Harding, C. V., & Geuze, H. J. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.119.3.531 · Cited by 164 · see citing works

Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression

Busch, R., Rinderknecht, C. H., Roh, S., Lee, A. W.-T., Harding, J. J., Burster, T., Hornell, T. M. C., & Mellins, E. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00306.x · Cited by 158 · see citing works

A Genome-wide Multidimensional RNAi Screen Reveals Pathways Controlling MHC Class II Antigen Presentation

Paul, P., van den Hoorn, T., Jongsma, M. L. M., Bakker, M. J., Hengeveld, R. C. C., Janssen, L., Cresswell, P., Egan, D. A., van Ham, S. M., ten Brinke, A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.03.023 · Cited by 155 · see citing works

Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance

Aichinger, M., Wu, C., Nedjic, J., & Klein, L. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20122149 · Cited by 151 · see citing works

A cytosolic pathway for MHC class II–restricted antigen processing that is proteasome and TAP dependent

Tewari, M. K., Sinnathamby, G., Rajagopal, D., & Eisenlohr, L. C. (2005) · Nature Immunology · doi:10.1038/ni1171 · Cited by 149 · see citing works

Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses

Taraban, V. Y., Rowley, T. F., O'Brien, L., Chan, H. T. C., Haswell, L. E., Green, M. H. A., Tutt, A. L., Glennie, M. J., & Al‐Shamkhani, A. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200212)32:12 · Cited by 149 · see citing works

MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells

LeibundGut‐Landmann, S., Waldburger, J., Sousa, C. R. E., Acha‐Orbea, H., & Reith, W. (2004) · Nature Immunology · doi:10.1038/ni1109 · Cited by 149 · see citing works

Autophagy and adaptive immunity

Crotzer, V. L., & Blum, J. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03321.x · Cited by 145 · see citing works

Inhibition of MHC Class II Expression and Immune Responses by c-MIR

Ohmura‐Hoshino, M., Matsuki, Y., Aoki, M., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.341 · Cited by 131 · see citing works

Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments

McCormick, P. J., Martina, J. A., & Bonifacino, J. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502206102 · Cited by 131 · see citing works

Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond

Lilley, B. N., & Ploegh, H. L. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00318.x · Cited by 131 · see citing works

Processing of Mycobacterium tuberculosis Antigen 85B Involves Intraphagosomal Formation of Peptide–Major Histocompatibility Complex II Complexes and Is Inhibited by Live Bacilli that Decrease Phagosome Maturation

Ramachandra, L., Noss, E. H., Boom, W. H., & Harding, C. V. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.10.1421 · Cited by 125 · see citing works

Dynamics of Major Histocompatibility Complex Class II Compartments during B Cell Receptor–mediated Cell Activation

Lankar, D., Vincent-Schneider, H., Briken, V., Yokozeki, T., Raposo, G., & Bonnerot, C. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011543 · Cited by 125 · see citing works

Differential Role of Actin, Clathrin, and Dynamin in Fcγ Receptor-mediated Endocytosis and Phagocytosis

Tse, S. M. L., Furuya, W., Gold, E., Schreiber, A. D., Sandvig, K., Inman, R. D., & Grinstein, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207966200 · Cited by 124 · see citing works

Inhibition of HLA-DR Assembly, Transport, and Loading by Human Cytomegalovirus Glycoprotein US3: a Novel Mechanism for Evading Major Histocompatibility Complex Class II Antigen Presentation

Hegde, N. R., Tomazin, R., Wisner, T. W., et al. (2002) · Journal of Virology · doi:10.1128/jvi.76.21.10929-10941.2002 · Cited by 122 · see citing works

Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distinct processing mechanisms

Griffin, J. P., Chu, R., & Harding, C. V. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.4.1523 · Cited by 120 · see citing works

CTLA-4 regulates cell cycle progression during a primary immune response

Greenwald, R. J., Oosterwegel, M. A., van der Woude, D., Kubal, A., Mandelbrot, D. A., Boussiotis, V. A., & Sharpe, A. H. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200202)32:2 · Cited by 120 · see citing works

MHC class II compartments and the kinetics of antigen presentation in activated mouse spleen dendritic cells.

Kleijmeer, M. J., Ossevoort, M. A., van Veen, C. J. H., van Hellemond, J. J., Neefjes, J., Kast, W. M., Melief, C. J. M., & Geuze, H. J. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.11.5715 · Cited by 119 · see citing works

Tumour‐derived exosomes as antigen delivery carriers in dendritic cell‐based immunotherapy for malignant mesothelioma

Mahaweni, N. M., Kaijen-Lambers, M. E. H., Dekkers, J., Aerts, J. G. J. V., & Hegmans, J. P. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.22492 · Cited by 119 · see citing works

Asparagine Endopeptidase Can Initiate the Removal of the MHC Class II Invariant Chain Chaperone

Manoury, B., Mazzeo, D., Li, D. N., et al. (2003) · Immunity · doi:10.1016/s1074-7613(03)00085-2 · Cited by 117 · see citing works

The Herpes Simplex Virus-1 Encoded Glycoprotein B Diverts HLA-DR into the Exosome Pathway

Temme, S., Eis‐Hübinger, A. M., McLellan, A. D., & Koch, N. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902192 · Cited by 116 · see citing works

The actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation

Vascotto, F., Lankar, D., Faure-André, G., Vargas, P., Diaz, J., Roux, D. L., Yuseff, M.-I., Sibarita, J., Boes, M. L., Raposo, G., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200611147 · Cited by 115 · see citing works

Ubiquitination of CD86 is a key mechanism in regulating antigen presentation by dendritic cells

Baravalle, G., Park, H., McSweeney, M., Ohmura-Hoshino, M., Matsuki, Y., Ishido, S., & Shin, J.-S. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101643 · Cited by 115 · see citing works

Ubiquitination regulates MHC class II-peptide complex retention and degradation in dendritic cells

Walseng, E., Furuta, K., Bosch, B., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010990107 · Cited by 113 · see citing works

Cutting Edge: Signals from the B Lymphocyte Antigen Receptor Regulate MHC Class II Containing Late Endosomes

Siemasko, K. F., Eisfelder, B. J., Williamson, E. K., et al. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.11.5203 · Cited by 113 · see citing works

Two processing pathways for the MHC class II-restricted presentation of exogenous influenza virus antigen.

Pinet, V., Malnati, M., & Long, E. O. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.10.4852 · Cited by 111 · see citing works

AP2 Clathrin Adaptor Complex, but Not AP1, Controls the Access of the Major Histocompatibility Complex (MHC) Class II to Endosomes

Dugast, M., Toussaint, H., Dousset, C., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501357200 · Cited by 105 · see citing works

Epstein-Barr Virus gp42 Is Posttranslationally Modified To Produce Soluble gp42 That Mediates HLA Class II Immune Evasion

Ressing, M. E., van Leeuwen, D., Verreck, F. A. W., Keating, S. E., Gomez, R., Franken, K. L. M. C., Ottenhoff, T. H. M., Spriggs, M. K., Schumacher, T. N., Hutt‐Fletcher, L. M., et al. (2004) · Journal of Virology · doi:10.1128/jvi.79.2.841-852.2005 · Cited by 103 · see citing works

Human cytomegalovirus protein pp65 mediates accumulation of HLA-DR in lysosomes and destruction of the HLA-DR α-chain

Odeberg, J., Plachter, B., Brandén, L. J., & Söderberg‐Nauclér, C. (2003) · Blood · doi:10.1182/blood-2002-05-1504 · Cited by 95 · see citing works

Dendritic Cells Continue To Capture and Present Antigens after Maturation In Vivo

Drutman, S. B., & Trombetta, E. S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000642 · Cited by 92 · see citing works

Autonomous phagosomal degradation and antigen presentation in dendritic cells

Hoffmann, E., Kotsias, F., Visentin, G., Bruhns, P., Savina, A., & Amigorena, S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203912109 · Cited by 88 · see citing works

TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentation

Mantegazza, A. R., Zajac, A. L., Twelvetrees, A. E., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412998111 · Cited by 86 · see citing works

Exploring the MHC-peptide matrix of central tolerance in the human thymus

Adamopoulou, E., Tenzer, S., Hillen, N., Klug, P., Rota, I. A., Tietz, S., Gebhardt, M., Stevanović, S., Schild, H., Tolosa, E., et al. (2013) · Nature Communications · doi:10.1038/ncomms3039 · Cited by 86 · see citing works

Human Immunodeficiency Virus-1 Nef Expression Induces Intracellular Accumulation of Multivesicular Bodies and Major Histocompatibility Complex Class II Complexes: Potential Role of Phosphatidylinositol 3-Kinase

Stumptner-Cuvelette, P., Jouve, M. J., Helft, J., Dugast, M., Glouzman, A.-S., Jooss, K. U., Raposo, G., & Benaroch, P. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-04-0211 · Cited by 82 · see citing works

MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells

Oh, J., Wu, N., Baravalle, G., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122695 · Cited by 82 · see citing works

Adaptor Protein-3 in Dendritic Cells Facilitates Phagosomal Toll-like Receptor Signaling and Antigen Presentation to CD4+ T Cells

Mantegazza, A. R., Guttentag, S. H., Benna, J. E., Sasai, M., Iwasaki, A., Shen, H., Laufer, T. M., & Marks, M. S. (2012) · Immunity · doi:10.1016/j.immuni.2012.02.018 · Cited by 81 · see citing works

Salmonella regulates polyubiquitination and surface expression of MHC class II antigens

Lapaque, N., Hutchinson, J. L., Jones, D. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906735106 · Cited by 80 · see citing works

Sorting of MHC Class II Molecules into Exosomes through a Ubiquitin‐Independent Pathway

Gauvreau, M., Côté, M., Bourgeois‐Daigneault, M., Rivard, L., Xiu, F., Brunet, A., Shaw, A., Steimle, V., & Thibodeau, J. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00948.x · Cited by 79 · see citing works

Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens

Young, L. J., Wilson, N. S., Schnorrer, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708622104 · Cited by 77 · see citing works

The lymph as a pool of self-antigens

Clement, C. C., Rötzschke, O., & Santambrogio, L. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.10.004 · Cited by 74 · see citing works

Right place, right time, right peptide: DO keeps DM focused

Denzin, L. K., Fallas, J. L., Prendes, M. J., & Yi, W. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00302.x · Cited by 73 · see citing works

Ubiquitin-mediated Regulation of CD86 Protein Expression by the Ubiquitin Ligase Membrane-associated RING-CH-1 (MARCH1)

Corcoran, K., Jabbour, M., Bhagwandin, C., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.204040 · Cited by 72 · see citing works

MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length

Jessica, K., Platt, M. Y., Eastham‐Anderson, J., Shin, J., & Mellman, I. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202977109 · Cited by 69 · see citing works

MHC class II association with lipid rafts on the antigen presenting cell surface

Anderson, H. A., & Roche, P. A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.09.019 · Cited by 69 · see citing works

Mass Spectrometry Analysis and Quantitation of Peptides Presented on the MHC II Molecules of Mouse Spleen Dendritic Cells

Bozzacco, L., Yu, H., Zebroski, H. A., Dengjel, J., Deng, H., Mojsov, S., & Steinman, R. M. (2011) · Journal of Proteome Research · doi:10.1021/pr200503g · Cited by 68 · see citing works

Human Resident Langerhans Cells Display a Lysosomal compartment Enriched in MHC Class II

Kleijmeer, M. J., Oorschot, V. M. J., & Geuze, H. J. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12395666 · Cited by 68 · see citing works

Discrete Domains of MARCH1 Mediate Its Localization, Functional Interactions, and Posttranscriptional Control of Expression

Jabbour, M., Campbell, E. M., Fares, H., & Lybarger, L. P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901521 · Cited by 67 · see citing works

Major Histocompatibility Complex (MHC) Class II-Peptide Complexes Arrive at the Plasma Membrane in Cholesterol-rich Microclusters

Bosch, B., Heipertz, E. L., Drake, J. R., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.442640 · Cited by 60 · see citing works

TRIF–GEFH1–RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T‐cell activation

Kamon, H., Kawabe, T., Kitamura, H., Lee, J., Kamimura, D., Kaisho, T., Akira, S., Iwamatsu, A., Koga, H., Murakami, M., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601286 · Cited by 60 · see citing works

LAMP‐2‐deficient human B cells exhibit altered MHC class II presentation of exogenous antigens

Crotzer, V. L., Glosson, N. L., Zhou, D., et al. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03309.x · Cited by 60 · see citing works

Pathogenic CD4+ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes

Mohan, J. F., Calderón, B., Anderson, M. S., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130582 · Cited by 57 · see citing works

Dendritic Cell Activation Prevents MHC Class II Ubiquitination and Promotes MHC Class II Survival Regardless of the Activation Stimulus

Walseng, E., Furuta, K., Goldszmid, R. S., Weih, K. A., Sher, A., & Roche, P. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.157586 · Cited by 55 · see citing works

Capture of cell-derived microvesicles (exosomes and apoptotic bodies) by human plasmacytoid dendritic cells

Bastos-Amador, P., Pérez‐Cabezas, B., Izquierdo‐Useros, N., Puertas, M. C., Martínez‐Picado, J., Pujol‐Borrell, R., Naranjo‐Gómez, M., & Borràs, F. E. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0111054 · Cited by 54 · see citing works

Syk-dependent Actin Dynamics Regulate Endocytic Trafficking and Processing of Antigens Internalized through the B-Cell Receptor

Roux, D. L., Lankar, D., Yuseff, M.-I., Vascotto, F., Yokozeki, T., Faure-André, G., Mougneau, E., Glaichenhaus, N., Manoury, B., Bonnerot, C., et al. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-12-1114 · Cited by 53 · see citing works

Robust T-cell stimulation by Epstein-Barr virus–transformed B cells after antigen targeting to DEC-205

Leung, C. S. K., Maurer, M., Meixlsperger, S., Lippmann, A., Cheong, C., Zuo, J., Haigh, T. A., Taylor, G. S., & Münz, C. (2013) · Blood · doi:10.1182/blood-2012-08-450775 · Cited by 52 · see citing works

Association of MHC class II–peptide complexes with plasma membrane lipid microdomains

Poloso, N. J., & Roche, P. A. (2003) · Current Opinion in Immunology · doi:10.1016/j.coi.2003.11.009 · Cited by 52 · see citing works

Epitope-specific enhancement of antigen presentation by invariant chain.

Momburg, F., Fuchs, S., Drexler, J. F., Busch, R., Post, M., Hämmerling, G. J., & Adorini, L. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.4.1453 · Cited by 51 · see citing works

SWAP-70 regulates RhoA/RhoB-dependent MHCII surface localization in dendritic cells

Ocaña‐Morgner, C., Wahren, C., & Jessberger, R. (2008) · Blood · doi:10.1182/blood-2008-04-152587 · Cited by 49 · see citing works

Francisella tularensis Induces Ubiquitin-Dependent Major Histocompatibility Complex Class II Degradation in Activated Macrophages

Wilson, J. E., Katkere, B., & Drake, J. R. (2009) · Infection and Immunity · doi:10.1128/iai.00844-09 · Cited by 47 · see citing works

Autoregulation of MARCH1 Expression by Dimerization and Autoubiquitination

Bourgeois‐Daigneault, M., & Thibodeau, J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102708 · Cited by 47 · see citing works

Francisella tularensis Elicits IL-10 via a PGE2-Inducible Factor, to Drive Macrophage MARCH1 Expression and Class II Down-Regulation

Hunt, D., Wilson, J. E., Weih, K. A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037330 · Cited by 41 · see citing works

MHC Class II Molecules Traffic into Lipid Rafts during Intracellular Transport

Poloso, N. J., Muntasell, A., & Roche, P. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.7.4539 · Cited by 40 · see citing works

Membrane Transfer from Tumor Cells Overcomes Deficient Phagocytic Ability of Plasmacytoid Dendritic Cells for the Acquisition and Presentation of Tumor Antigens

Bonaccorsi, I., Morandi, B., Antsiferova, O., Costa, G., Oliveri, D., Conte, R., Pezzino, G., Vermiglio, G., Anastasi, G., Navarra, G., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301039 · Cited by 40 · see citing works

Location of Major Histocompatibility Complex Class II Molecules in Rafts on Dendritic Cells Enhances the Efficiency of T‐Cell Activation and Proliferation

Eren, E., Yates, J., Cwynarski, K., Preston, S. G., Dong, R., Germain, C., Lechler, R. I., Huby, R. D. J., Ritter, M. A., & Lombardi, G. (2005) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2006.01700.x · Cited by 40 · see citing works

Internalizing MHC class II–peptide complexes are ubiquitinated in early endosomes and targeted for lysosomal degradation

Furuta, K., Walseng, E., & Roche, P. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312994110 · Cited by 39 · see citing works

CD83 localization in a recycling compartment of immature human monocyte-derived dendritic cells

Klein, E. (2005) · International Immunology · doi:10.1093/intimm/dxh228 · Cited by 37 · see citing works

The Pathway of Antigen Uptake and Processing Dictates MHC Class II-Mediated B Cell Survival and Activation

Nashar, T. O., & Drake, J. R. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.3.1306 · Cited by 33 · see citing works

Encounter with antigen-specific primed CD4 T cells promotes MHC class II degradation in dendritic cells

Furuta, K., Ishido, S., & Roche, P. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213868109 · Cited by 29 · see citing works

TLR signalling and phagosome maturation: an alternative viewpoint

Russell, D. G., & Yates, R. M. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.00920.x · Cited by 26 · see citing works

Epstein-Barr Virus Evades CD4+ T Cell Responses in Lytic Cycle through BZLF1-mediated Downregulation of CD74 and the Cooperation of vBcl-2

Zuo, J., Thomas, W., Haigh, T., Fitzsimmons, L., Long, H. M., Hislop, A. D., Taylor, G. S., & Rowe, M. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002455 · Cited by 23 · see citing works

Endosomally Stored MHC Class II Does Not Contribute to Antigen Presentation by Dendritic Cells at Inflammatory Conditions

ten Broeke, T., van Niel, G., Wauben, M. H. M., et al. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01212.x · Cited by 22 · see citing works

Human Immunodeficiency Virus Type 1 Nef Expression Prevents AP-2-Mediated Internalization of the Major Histocompatibility Complex Class II-Associated Invariant Chain

Toussaint, H., Gobert, F.-X., Schindler, M., et al. (2008) · Journal of Virology · doi:10.1128/jvi.00670-08 · Cited by 22 · see citing works

Association of Major Histocompatibility Complex II with Cholesterol- and Sphingolipid-rich Membranes Precedes Peptide Loading

Karacsonyi, C., Knorr, R., Fülbier, A., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404608200 · Cited by 17 · see citing works

Identification of a novel motif that affects the conformation and activity of the MARCH1 E3 ubiquitin ligase

Bourgeois‐Daigneault, M., & Thibodeau, J. (2012) · Journal of Cell Science · doi:10.1242/jcs.117804 · Cited by 13 · see citing works

Immunogenic cell death in cancer and infectious disease

Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119 · see citing works

Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy

Topalian, S. L., Taube, J. M., Anders, R. A., & Pardoll, D. M. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.36 · Cited by 2,733 · see citing works

The dawn of mRNA vaccines: the COVID-19 case

Verbeke, R., Lentacker, I., De Smedt, S. C., & Dewitte, H. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.03.043 · Cited by 504 · see citing works

COVID-19 vaccines: The status and perspectives in delivery points of view

Chung, J. Y., Thone, M. N., & Kwon, Y. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.011 · Cited by 375 · see citing works

Role of B cells as antigen presenting cells

Rastogi, I., Jeon, D., Moseman, J. E., Muralidhar, A., Potluri, H. K., & McNeel, D. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.954936 · Cited by 352 · see citing works

Radiation therapy and anti-tumor immunity: exposing immunogenic mutations to the immune system

Lhuillier, C., Rudqvist, N.-P., Elemento, O., Formenti, S. C., & Demaria, S. (2019) · Genome Medicine · doi:10.1186/s13073-019-0653-7 · Cited by 276 · see citing works

Overcoming innate immune barriers that impede AAV gene therapy vectors

Muhuri, M., Maeda, Y., Ma, H., Ram, S., Fitzgerald, K. A., Tai, P. W. L., & Gao, G. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143780 · Cited by 212 · see citing works

Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across

Minnaert, A.-K., Vanluchene, H., Verbeke, R., Lentacker, I., De Smedt, S. C., Raemdonck, K., Sanders, N. N., & Remaut, K. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113900 · Cited by 157 · see citing works

Evaluating and mitigating the immunogenicity of therapeutic proteins

Sauna, Z. E., Lagassé, D., Pedras-Vasconcelos, J., Golding, B., & Rosenberg, A. S. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.05.008 · Cited by 118 · see citing works

IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer’s Disease

Lau, S.-F., Chen, C., Fu, W.-Y., Qu, J. Y., Cheung, T. H., Fu, A. K. Y., & Ip, N. Y. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107530 · Cited by 114 · see citing works

Global survey of the immunomodulatory potential of common drugs

Vladimer, G. I., Snijder, B., Krall, N., Bigenzahn, J. W., Huber, K. V. M., Lardeau, C.-H., Sanjiv, K., Ringler, A., Berglund, U. W., Sabler, M., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2360 · Cited by 87 · see citing works

Toll-like receptor 9 antagonizes antibody affinity maturation

Akkaya, M., Akkaya, B., Kim, A. S., Miozzo, P., Sohn, H., Pena, M., Roesler, A. S., Theall, B. P., Henke, T., Kabat, J., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0052-z · Cited by 66 · see citing works

Gene knockout inference with variational graph autoencoder learning single-cell gene regulatory networks

Yang, Y., Li, G., Zhong, Y., Xu, Q., Chen, B.-J., Lin, Y.-T., Chapkin, R. S., & Cai, J. J. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad450 · Cited by 48 · see citing works

Carbohydrate Immune Adjuvants in Subunit Vaccines

Bashiri, S., Koirala, P., Toth, I., & Skwarczynski, M. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12100965 · Cited by 45 · see citing works

Shaping of Peripheral T Cell Responses by Lymphatic Endothelial Cells

Humbert, M., Hugues, S., & Dubrot, J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00684 · Cited by 32 · see citing works

Comparative analysis of transcriptome remodeling in plaque-associated and plaque-distant microglia during amyloid-β pathology progression in mice

Hemonnot-Girard, A.-L., Meersseman, C., Pastore, M., Garcia, V., Linck, N., Rey, C., Chebbi, A., Jeanneteau, F., Ginsberg, S. D., Lachuer, J., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02581-0 · Cited by 24 · see citing works

Adeno-Associated Virus D-Sequence-Mediated Suppression of Expression of a Human Major Histocompatibility Class II Gene: Implications in the Development of Adeno-Associated Virus Vectors for Modulating Humoral Immune Response

Kwon, H.-J., Qing, K., Ponnazhagan, S., Wang, X.-S., Markusic, D. M., Gupte, S., Boye, S. E., & Srivastava, A. (2020) · Human Gene Therapy · doi:10.1089/hum.2020.018 · Cited by 6 · see citing works

Whole‐Genome Sequencing and Single‐Cell Transcriptomics Identify Human Leukocyte Antigen Loci and a <i>COG5</i> Variant in Aortic Dissection

Lin, J., Wu, S., Lin, C., Jin, S., Chen, L., Luo, J., Xu, S., Jin, L., Yu, M., Zheng, Y., et al. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.126.050327

Principles of MHC class I-mediated antigen presentation and T cell selection.

Ljunggren, H., & Thorpe, C. J. (1996) · PubMed · Cited by 9 · see citing works

Electroporation of exogenous antigen into the cytosol for antigen processing and class I major histocompatibility complex (MHC) presentation: weak base amines and hypothermia (18°C) inhibit the class I MHC processing pathway

Harding, C. V. (1992) · European Journal of Immunology · doi:10.1002/eji.1830220728 · Cited by 37 · see citing works

HLA-DM and the MHC class II antigen presentation pathway

Jensen, P. E., Weber, D. A., Thayer, W. P., et al. (1999) · Immunologic Research · doi:10.1007/bf02790403 · Cited by 47 · see citing works

Intracellular transport of MHC class II molecules

Neefjes, J., & Ploegh, H. L. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90123-o · Cited by 215 · see citing works

Antigen presentation by MHC class II molecules

Weenink, S. M., & Gautam, A. M. (1997) · Immunology and Cell Biology · doi:10.1038/icb.1997.11 · Cited by 47 · see citing works