The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Prevention of Vaginal SHIV Transmission in Rhesus Macaques Through Inhibition of CCR5
Open accessAbstract
Topical agents, such as microbicides, that can protect against human immunodeficiency virus (HIV) transmission are urgently needed. Using a chimeric simian/human immunodeficiency virus (SHIV SF162), which is tropic for the chemokine receptor CCR5, we report that topical application of high doses of PSC-RANTES, an amino terminus–modified analog of the chemokine RANTES, provided potent protection against vaginal challenge in rhesus macaques. These experimental findings have potentially important implications for understanding vaginal transmission of HIV and the design of strategies for its prevention.
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Citations
Cites
Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease
Berger, E. A., Murphy, P. M., & Farber, J. M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.657 · Cited by 2,180
Transmission, acute HIV-1 infection and the quest for strategies to prevent infection
Pope, M., & Haase, A. T. (2003) · Nature Medicine · doi:10.1038/nm0703-847 · Cited by 355
Target cells in vaginal HIV transmission
Miller, C. J., & Shattock, R. J. (2003) · Microbes and Infection · doi:10.1016/s1286-4579(02)00056-4 · Cited by 220
Cited by
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
Perez, E. E., Wang, J., Miller, J. C., Jouvenot, Y., Kim, K. A., Liu, O., Wang, N., Lee, G., Bartsevich, V. V., Lee, Y.-L., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1410 · Cited by 999
Targeting early infection to prevent HIV-1 mucosal transmission
Haase, A. T. (2010) · Nature · doi:10.1038/nature08757 · Cited by 593
HIV disease: fallout from a mucosal catastrophe?
Brenchley, J. M., Price, D. A., & Douek, D. C. (2006) · Nature Immunology · doi:10.1038/ni1316 · Cited by 579
Perils at mucosal front lines for HIV and SIV and their hosts
Haase, A. T. (2005) · Nature Reviews Immunology · doi:10.1038/nri1706 · Cited by 440
Ghosh, T., Chattopadhyay, K., Marschall, M., Karmakar, P., Mandal, P., & Ray, B. (2009) · Glycobiology · doi:10.1093/glycob/cwn092 · Cited by 391
Metadata
- Authors
- Lederman, M. M., Veazey, R. S., Offord, R., Mosier, D. E., Dufour, J., Mefford, M., Piatak, M., Lifson, J. D., Salkowitz, J. R., Rodriguez, B., Blauvelt, A., & Hartley, O.
- Venue
- Science
- Published
- 2004-10-15
- Volume
- 306
- Issue
- 5695
- Pages
- 485-487
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2145718464
- Cited by
- 352
- References
- 3
- FWCI
- 12.09
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Prevention of Vaginal SHIV Transmission in Rhesus Macaques Through Inhibition of CCR5. https://app.cochat.ai/papers/10.1126/science.1099288
- The paper
- Lederman, M. M., Veazey, R. S., Offord, R., Mosier, D. E., Dufour, J., Mefford, M., Piatak, M., Lifson, J. D., Salkowitz, J. R., Rodriguez, B., Blauvelt, A., & Hartley, O. (2004). Prevention of Vaginal SHIV Transmission in Rhesus Macaques Through Inhibition of CCR5. Science. https://doi.org/10.1126/science.1099288
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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