Multidimensional Drug Profiling By Automated Microscopy
Perlman, Zachary E., Slack, Michael D., Feng, Yan, Mitchison, Timothy J., Wu, Lani F., Altschuler, Steven J.·2004·Science
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- Collecting and organizing systematic sets of protein dataJohn G. Albeck, Gavin MacBeath, Forest M. White, Peter Karl Sorger, Douglas A. Lauffenburger, Suzanne Gaudet · 2006 · Nature Reviews Molecular Cell Biology
- High throughput microscopy: from raw images to discoveriesRoy Wollman, Nico Stuurman · 2007 · Journal of Cell Science
- Single-cell and multivariate approaches in genetic perturbation screensPrisca Liberali, Berend Snijder, Lucas Pelkmans · 2014 · Nature Reviews Genetics
- Closed-form density-based framework for automatic detection of cellular morphology changesTarn Duong, Bruno Goud, Kristine Schauer · 2012 · Proceedings of the National Academy of Sciences
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- CRISPR Approaches to Small Molecule Target IdentificationJost, Marco, Weissman, Jonathan S. · 2018 · ACS Chemical Biology
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- Linking Phenotypes and Modes of Action Through High-Content Screen FingerprintsReisen, Felix, Sauty de Chalon, Amelie, Pfeifer, Martin, Zhang, Xian, Gabriel, Daniela, Selzer, Paul · 2015 · ASSAY and Drug Development Technologies
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- Small molecule screening by imagingUlrike Eggert, Timothy John Mitchison · 2006 · Current Opinion in Chemical Biology
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- High‐Content Analysis in Toxicology: Screening Substances for Human Toxicity Potential, Elucidating Subcellular Mechanisms and In Vivo Use as Translational Safety BiomarkersPeter James O'Brien · 2014 · Basic & Clinical Pharmacology & Toxicology
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- Affinity-based target identification for bioactive small moleculesMakoto Kawatani, Hiroyuki Osada · 2013 · MedChemComm
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- Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytesLit‐Hsin Loo, Hai-Jui Lin, Dinesh Kumar Singh, Kathleen M. Lyons, Steven J. Altschuler, Lani F. Wu · 2009 · The Journal of Cell Biology
- Target identification of small molecules based on chemical biology approachesYushi Futamura, Makoto Muroi, Hiroyuki Osada · 2013 · Molecular BioSystems
- Large‐scale image‐based screening and profiling of cellular phenotypesNicola Michelle Bougen-Zhukov, Sheng Yang Michael Loh, Hwee Kuan Lee, Lit‐Hsin Loo · 2016 · Cytometry Part A
- Automated neurite labeling and analysis in fluorescence microscopy imagesGuanglei Xiong, Xiaobo Zhou, Alexei Degterev, Liang Ji, Stephen T. C. Wong · 2006 · Cytometry Part A
- The principle of complementarity: chemical versus biological spaceStephen J. Haggarty · 2005 · Current Opinion in Chemical Biology
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- High Content Cell Screening in a Microfluidic DeviceRaymond Cheong, Chiaochun Joanne Wang, Andre Levchenko · 2008 · Molecular & Cellular Proteomics
- A high-content image-based method for quantitatively studying context-dependent cell population dynamicsColleen M. Garvey, Erin R. Spiller, Danika Lindsay, Chun-Te Chiang, Nathan C. Choi, David B. Agus, Parag Mallick, Jasmine Foo, Shannon M. Mumenthaler · 2016 · Scientific Reports
- Laser autofocusing system for high‐resolution cell biological imagingYuvalal Liron, Yael Paran, N. G. ZATORSKY, Benjamin Geiger, Zvi Kam · 2006 · Journal of Microscopy
- An approach for extensibly profiling the molecular states of cellular subpopulationsLoo, Lit-Hsin, Lin, Hai-Jui, Steininger, Robert J, Wang, Yanqin, Wu, Lani F, Altschuler, Steven J · 2009 · Nature Methods
- High content cellular screeningOliver Rausch · 2006 · Current Opinion in Chemical Biology
- Small Molecules, Big Players: the National Cancer Institute's Initiative for Chemical GeneticsNicola J. Tolliday, Paul A. Clemons, Paul Ferraiolo, Angela N. Koehler, Timothy A. Lewis, Xiaohua Li, Stuart L. Schreiber, Daniela Se Gerhard, Scott D. Eliasof · 2006 · Cancer Research
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- Automatic analysis of dividing cells in live cell movies to detect mitotic delays and correlate phenotypes in timeNathalie Harder, Felipe Mora‐Bermúdez, William J. Godinez, Annelie Wünsche, Roland Eils, Jan Ellenberg, Karl Rohr · 2009 · Genome Research
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- Nanomaterials for Biosensors and Implantable BiodevicesRoberto A. S. Luz, Rodrigo M. Iost, Frank N. Crespilho · 2012 · Springer eBooks
- Multiparametric Cell Cycle Analysis by Automated MicroscopyFabio Gasparri, Paolo Cappella, Arturo P. Galvani · 2006 · SLAS DISCOVERY
- Public Domain HTS Fingerprints: Design and Evaluation of Compound Bioactivity Profiles from PubChem’s Bioassay RepositoryKazi Yasin Helal, Mateusz Maciejewski, Elisabet Gregori‐Puigjané, Meir Glick, Anne Mai Wassermann · 2016 · Journal of Chemical Information and Modeling
- Tales of 1,008 small molecules: phenomic profiling through live-cell imaging in a panel of reporter cell linesMichael J. Cox, Steffen Jaensch, Jelle Van de Waeter, Laure Cougnaud, Daan Seynaeve, Soulaiman Benalla, Seong Joo Koo, Ilse Van den Wyngaert, Jean‐Marc Neefs, Dmitry Malkov et al. · 2020 · Scientific Reports
- Phenotypic drug profiling in droplet microfluidics for better targeting of drug-resistant tumorsSaheli Sarkar, Noa Cohen, Pooja Sabhachandani, Tania Konry · 2015 · Lab on a Chip
- A novel permalloy based magnetic single cell micro arrayWilliam Liu, Nikolai Dechev, Ian G. Foulds, Robert D. Burke, Ash M. Parameswaran, Edward J. Park · 2009 · Lab on a Chip
- The development of high-content screening (HCS) technology and its importance to drug discoveryIvan Fraietta, Fabio Gasparri · 2016 · Expert Opinion on Drug Discovery
- Intelligent whole-blood imaging flow cytometry for simple, rapid, and cost-effective drug-susceptibility testing of leukemiaHirofumi Kobayashi, Cheng Lei, Yi Wu, Chun‐Jung Huang, Atsushi Yasumoto, Masahiro Jona, Wenxuan Li, Yunzhao Wu, Yaxiaer Yalikun, Yiyue Jiang et al. · 2019 · Lab on a Chip
- Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversityIvan Pavlinov, Erica M. Gerlach, Leslie N. Aldrich · 2018 · Organic & Biomolecular Chemistry
- Large-scale cytological profiling for functional analysis of bioactive compoundsWoehrmann, Marcos H, Bray, Walter M, Durbin, James K, Nisam, Sean C, Michael, Alicia K, Glassey, Emerson, Stuart, Joshua M, Lokey, R. Scott · 2013 · Molecular BioSystems
- NeuronMetrics: Software for semi-automated processing of cultured neuron imagesMartha L. Narro, Fan Yang, Robert Kraft, Carola Wenk, Alon Efrat, Linda L. Restifo · 2007 · Brain Research
- Generation of a fluorescently labeled endogenous protein library in living human cellsAlex Sigal, Tamar Danon, Ariel Cohen, Ron Milo, Naama Geva‐Zatorsky, Gila Lustig, Yuvalal Liron, Uri S. Alon, Natalie Perzov · 2007 · Nature Protocols
- Vacuolin‐1 inhibits autophagy by impairing lysosomal maturation via PIK fyve inhibitionOsamu Sano, Ken‐ichi Kazetani, Masaaki Funata, Yasunori Fukuda, Junji Matsui, Hidehisa Iwata · 2016 · FEBS Letters
- High-content phenotypic and pathway profiling to advance drug discovery in diseases of unmet needHughes, Rebecca E., Elliott, Richard J.R., Dawson, John C., Carragher, Neil O. · 2021 · Cell Chemical Biology
- How to Understand the Cell by Breaking It: Network Analysis of Gene Perturbation ScreensFlorian M. Markowetz · 2010 · PLoS Computational Biology
- Multispot live‐image autofocusing for high‐throughput microscopy of fluorescently stained bacteriaMichael Zeder, Jakob Pernthaler · 2009 · Cytometry Part A
- Identifying and Quantifying Heterogeneity in High Content Analysis: Application of Heterogeneity Indices to Drug DiscoveryAlbert Gough, Ning Chen, Tong Ying Shun, Timothy R. Lezon, Robert C. Boltz, Celeste E. Reese, Jacob Wagner, Lawrence A. Vernetti, Jennifer Rubin Grandis, Adrian V. Lee et al. · 2014 · PLoS ONE
- Deep learning large-scale drug discovery and repurposingMin Yu, Weiming Li, Yunru Yu, Yu Zhao, Lizhi Xiao, Volker Martin Lauschke, Yi-Yu Cheng, Xingcai Zhang, Yì Wáng · 2024 · Nature Computational Science
- Network Crosstalk Dynamically Changes during Neutrophil PolarizationChin‐Jen Ku, Yanqin Wang, Orion David Weiner, Steven J. Altschuler, Lani F. Wu · 2012 · Cell
- Comparison of Cellular Morphological Descriptors and Molecular Fingerprints for the Prediction of Cytotoxicity- and Proliferation-Related AssaysSrijit Seal, Hongbin Yang, Luis Vollmers, Andreas Bender · 2021 · Chemical Research in Toxicology
- Multiplexing Methods for Simultaneous Large‐Scale Transcriptomic Profiling of Samples at Single‐Cell ResolutionJunyun Cheng, Jie Liao, Xin Shao, Xiaoyan Lu, Xiaohui Fan · 2021 · Advanced Science
- Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compoundsMohammad Akbarzadeh, Ilka Deipenwisch, Beate Schoelermann, Axel Pahl, Sonja Sievers, Slava Ziegler, Herbert Waldmann · 2021 · Cell chemical biology
- Computer vision for high content screeningOren Z. Kraus, Brendan J. Frey · 2016 · Critical Reviews in Biochemistry and Molecular Biology
- Automatic Robust Neurite Detection and Morphological Analysis of Neuronal Cell Cultures in High-content ScreeningChaohong Wu, Joost Schulte, Katharine J. Sepp, J. Troy Littleton, Pengyu Hong · 2010 · Neuroinformatics
- In Vitro Cytotoxicity AssessmentPeter James O'Brien, Jeffrey R. Haskins · 2006 · Humana Press eBooks
- Automatic identification and clustering of chromosome phenotypes in a genome wide RNAi screen by time-lapse imagingThomas Walter, Michael Held, Beate Neumann, Jean-Karim Hèriché, Christian Conrad, Rainer Pepperkok, Jan Ellenberg · 2009 · Journal of Structural Biology
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- Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasisHyokyeong Lee, Asher Moody-Davis, Utsab Saha, Brian M. Suzuki, Daniel E. Asarnow, Steven Chen, Michelle R. Arkin, Conor R. Caffrey, Rahul Singh · 2012 · BMC Genomics
- Signal Transduction at the Single-Cell Level: Approaches to Study the Dynamic Nature of Signaling NetworksL. Naomi Handly, Jason J. Yao, Roy Wollman · 2016 · Journal of Molecular Biology
- Compound Classification Using Image‐Based Cellular PhenotypesAdams, Cynthia L., Kutsyy, Vadim, Coleman, Daniel A., Cong, Ge, Crompton, Anne Moon, Elias, Kathleen A., Oestreicher, Donald R., Trautman, Jay K., Vaisberg, Eugeni · 2006 · Methods in Enzymology
- Artificial intelligence for high content imaging in drug discoveryJordi Carreras Puigvert, Ola Spjuth · 2024 · Current Opinion in Structural Biology
- Identification of a Small-Molecule Inhibitor of DNA Topoisomerase II by Proteomic ProfilingMakoto Kawatani, Hiroshi Takayama, Makoto Muroi, Shinya H Kimura, Taira Maekawa, Hiroyuki Osada · 2011 · Chemistry & Biology
- Object‐oriented image analysis for high content screening: Detailed quantification of cells and sub cellular structures with the Cellenger softwareMartin Baatz, Nick Arini, Arno Schäpe, Gerd K. Binnig, Bettina Linssen · 2006 · Cytometry Part A
- High content image analysis for human H4 neuroglioma cells exposed to CuO nanoparticlesFuhai Li, Xiaobo Zhou, Jinmin Zhu, Jinwen Ma, Xudong Huang, Stephen T. C. Wong · 2007 · BMC Biotechnology
- Towards Automated Cellular Image Segmentation for RNAi Genome-Wide ScreeningXiaobo Zhou, Ke’nan Liu, Pamela L. Bradley, Norbert Perrimon, Stephen T. C. Wong · 2005 · Lecture notes in computer science
- High‐Content Screening and Profiling of Drug Activity in an Automated Centrosome‐Duplication AssayZachary E. Perlman, Timothy John Mitchison, Thomas U. Mayer · 2004 · ChemBioChem
- Toward high‐content/high‐throughput imaging and analysis of embryonic morphogenesisThai V. Truong, Willy Supatto · 2011 · genesis
- Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screensZheng Yin, Xiaobo Zhou, Chris Bakal, Fuhai Li, Youxian Sun, Norbert Perrimon, Stephen T. C. Wong · 2008 · BMC Bioinformatics
- Computational Biology and Drug Discovery: From Single-Target to Network DrugsAmbesi-Impiombato, Alberto, Bernardo, Diego · 2006 · Current Bioinformatics
- High-Content Screening: A Decade of EvolutionNick Thomas · 2009 · SLAS DISCOVERY
- Light microscopy applications in systems biology: opportunities and challengesPaul M. A. Antony, Christophe Trefois, Aleksandar Stojanović, Aidos Baumuratov, Karol Kozak · 2013 · Cell Communication and Signaling
- Deep learning takes on tumoursEsther Wei-Yun Landhuis · 2020 · Nature
- Marine dissolved organic matter: a vast and unexplored molecular spaceTeresa S. Catalá, Spencer L. Shorte, Thorsten Dittmar · 2021 · Applied Microbiology and Biotechnology
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- Next-generation biomarkers based on 100-parameter functional super-resolution microscopy TISWALTER J. SCHUBERT, Anne Gieseler, Andreas Krusche, Peter Serocka, Reyk Hillert · 2011 · New Biotechnology
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- Next-Generation Phenotypic ScreeningScott J. Warchal, Asier Unciti‐Broceta, Neil O. Carragher · 2016 · Future Medicinal Chemistry
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- Computational Processing and Analysis of Dynamic Fluorescence Image DataJonas F. Dorn, Gaudenz M. Danuser, Ge Yang · 2008 · Methods in cell biology
- Core-shell hydrogel beads with extracellular matrix for tumor spheroid formationLi Yu, Samantha M. Grist, S. Soroush Nasseri, Eric Cheng, Y.-C. E. Hwang, Cynthia Ni, Karen C. Cheung · 2015 · Biomicrofluidics