Cited by 435Origins and Evolution of LifeEvolution and Genetic DynamicsRNA and protein synthesis mechanisms

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The Emergence of Competition Between Model Protocells

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Chen, Irene A., Roberts, Richard W., Szostak, Jack W.·2004·Science

DOI 10.1126/science.1100757PMC PMC4484590

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Abstract

The transition from independent molecular entities to cellular structures with integrated behaviors was a crucial aspect of the origin of life. We show that simple physical principles can mediate a coordinated interaction between genome and compartment boundary, independent of any genomic functions beyond self-replication. RNA, encapsulated in fatty acid vesicles, exerts an osmotic pressure on the vesicle membrane that drives the uptake of additional membrane components, leading to membrane growth at the expense of relaxed vesicles, which shrink. Thus, more efficient RNA replication could cause faster cell growth, leading to the emergence of Darwinian evolution at the cellular level.

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Authors: Chen, I. A., Roberts, R. W., & Szostak, J. W.
Affiliations: California Institute of Technology (US)
Corresponding author: Szostak, Jack W.
ORCID: Chen, Irene A.
Roberts, Richard W.
Szostak, Jack W.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2004-09-03
Volume: 305
Issue: 5689
Pages: 1474-1476
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1100757
PMC: PMC4484590
OpenAlex: W2166637067
Cited by: 435
References: 20
Citations by year: 2026: 20 · 2025: 12 · 2024: 19 · 2023: 13 · 2022: 32 · 2021: 22 · 2020: 16 · 2019: 20 · 2018: 19 · 2017: 25 · 2016: 18 · 2015: 19 · 2014: 18 · 2013: 21 · 2012: 32
FWCI: 9.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institute of General Medical Sciences (T32-GM08313, T32GM008313, T32 GM07753, T32GM007753)
Topics: Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: origin of life, protocells, RNA replication, fatty acid vesicles, osmotic pressure, membrane growth, compartment boundaries, Darwinian evolution, cell growth
MeSH terms: Cell Physiological Phenomena, Biological Evolution, Fatty Acids, Fatty Acids, Monounsaturated, Liposomes, Osmotic Pressure, RNA, RNA, Transfer, Genome, Oleic Acid, Fluorescence Resonance Energy Transfer

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The Emergence of Competition Between Model Protocells

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