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Small CTD Phosphatases Function in Silencing Neuronal Gene Expression
Abstract
Neuronal gene transcription is repressed in non-neuronal cells by the repressor element 1 (RE-1)–silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) complex. To understand how this silencing is achieved, we examined a family of class-C RNA polymerase II (RNAPII) carboxyl-terminal domain (CTD) phosphatases [small CTD phosphatases (SCPs) 1 to 3], whose expression is restricted to non-neuronal tissues. We show that REST/NRSF recruits SCPs to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Likewise, small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells. Thus, SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes.
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In the citing paper
“As part of the REST complex, these enzymes dephosphorylate the C-terminal domain (CTD) of RNA polymerase II (PolII) and thereby inhibit the expression of genes that have an RE1 signature sequence (Yeo et al. 2005;Visvanathan et al. 2007).”
From Intronic miR-26b controls neuronal differentiation by repressing its host transcript,ctdsp2 (2012) · cites this paper as Yeo et al. 2005
In the citing paper
“During neural fate commitment and terminal differentiation, the REST/CTDSP pathway is gradually inactivated to allow the expression of RE1-containing genes (Ballas et al. 2005;Yeo et al. 2005;Visvanathan et al. 2007).”
From Intronic miR-26b controls neuronal differentiation by repressing its host transcript,ctdsp2 (2012) · cites this paper as Yeo et al. 2005
In the citing paper
“This leads to the derepression of RE1containing genes (Yeo et al. 2005), including miR-124 (Supplemental Fig. S8), which exerts additional negative feedback to ctdsp2 expression (Supplemental Fig. S8C,D).”
From Intronic miR-26b controls neuronal differentiation by repressing its host transcript,ctdsp2 (2012) · cites this paper as Yeo et al. 2005
Citations
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Sorted by citations
Genome-Wide Mapping of in Vivo Protein-DNA Interactions
Johnson, D. S., Mortazavi, A., Myers, R. M., & Wold, B. (2007) · Science · doi:10.1126/science.1141319 · Cited by 2,927
Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395
Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits
Xue, Y., Ouyang, K., Huang, J., Zhou, Y., Ouyang, H., Li, H., Wang, G., Wu, Q., Wei, C., Bi, Y., et al. (2013) · Cell · doi:10.1016/j.cell.2012.11.045 · Cited by 562
Intronic miR-26b controls neuronal differentiation by repressing its host transcript,ctdsp2
Dill, H., Linder, B., Fehr, A., & Fischer, U. (2012) · Genes & Development · doi:10.1101/gad.177774.111 · Cited by 125
Metadata
- Authors
- Yeo, M., Lee, S.-K., Lee, B., Ruiz, E. C., Pfaff, S. L., & Gill, G. N.
- Affiliations
- Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
- Venue
- Science
- Published
- 2005-01-28
- Volume
- 307
- Issue
- 5709
- Pages
- 596-600
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 183
- References
- 1
- Language
- en
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