The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
A Link Between mRNA Turnover and RNA Interference in Arabidopsis
Abstract
In RNA interference (RNAi), double-stranded RNA (dsRNA) triggers degradation of homologous messenger RNA. In many organisms, RNA-dependent RNA polymerase (RdRp) is required to initiate or amplify RNAi, but the substrate for dsRNA synthesis in vivo is not known. Here, we show that RdRp-dependent transgene silencing in Arabidopsis was caused by mutation of XRN4, which is a ribonuclease (RNase) implicated in mRNA turnover by means of decapping and 5′-3′ exonucleolysis. When both XRN4 and the RdRp were mutated, the plants accumulated decapped transgene mRNA. We propose that mRNAs lacking a cap structure become exposed to RdRp to initiate or maintain RNAi.
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Cites
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A member of the KNOTTED class of homeodomain proteins encoded by the STM gene of Arabidopsis
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Cited by
Small silencing RNAs: an expanding universe
Ghildiyal, M., & Zamore, P. D. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2504 · Cited by 2,325
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies
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The expanding world of small RNAs in plants
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The diversity of RNA silencing pathways in plants
BRODERSEN, P., & VOINNET, O. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.03.003 · Cited by 732
Reconsidering plant memory: Intersections between stress recovery, RNA turnover, and epigenetics
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Metadata
- Authors
- Gazzani, S., Lawrenson, T., Woodward, C., Headon, D., & Sablowski, R.
- Venue
- Science
- Published
- 2004-11-05
- Volume
- 306
- Issue
- 5698
- Pages
- 1046-1048
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994914565
- Cited by
- 321
- References
- 24
- FWCI
- 23.62
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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