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The enzymes and control of eukaryotic mRNA turnover

Parker, Roy, Song, Haiwei·2004·Nature Structural & Molecular Biology
DOI 10.1038/nsmb724
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Abstract

The degradation of eukaryotic mRNAs plays important roles in the modulation of gene expression, quality control of mRNA biogenesis and antiviral defenses. In the past five years, many of the enzymes involved in this process have been identified and mechanisms that modulate their activities have begun to be identified. In this review, we describe the enzymes of mRNA degradation and their properties. We highlight that there are a variety of enzymes with different specificities, suggesting that individual nucleases act on distinct subpopulations of transcripts within the cell. In several cases, translation factors that bind mRNA inhibit these nucleases. In addition, recent work has begun to identify distinct mRNP complexes that recruit the nucleases to transcripts through different mRNA-interacting proteins. These properties and complexes suggest multiple mechanisms by which mRNA degradation could be regulated.

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Authors
Parker, R., & Song, H.
Venue
Nature Structural & Molecular Biology
Publisher
Springer Science and Business Media LLC
Published
2004-02
Volume
11
Issue
2
Pages
121-127
ISSN
  • 1545-9993
  • 1545-9985
DOI
10.1038/nsmb724
Cited by
730
References
1
Language
en
Licence
www.springer.com/tdm (tdm)

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